Host Protein General Information

  Protein Name
Caspase-3
  Gene Name
CASP3
  Host Species
Homo sapiens
  Uniprot Entry Name
CASP3_HUMAN
  Protein Families
Peptidase C14A family
  EC Number
3.4.22.56
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
836
Uniprot ID
P42574
Ensembl ID
ENSG00000122515
HGNC ID
1504
  Related KEGG Pathway
Cytosolic DNA-sensing pathway hsa04623            Pathway Map 
Natural killer cell mediated cytotoxicity hsa04650            Pathway Map 
IL-17 signaling pathway hsa04657            Pathway Map 
Epithelial cell signaling in Helicobacter pylori infection hsa05120            Pathway Map 
Pathogenic Escherichia coli infection hsa05130            Pathway Map 
Salmonella infection hsa05132            Pathway Map 
Pertussis hsa05133            Pathway Map 
Legionellosis hsa05134            Pathway Map 
Toxoplasmosis hsa05145            Pathway Map 
Amoebiasis hsa05146            Pathway Map 
Tuberculosis hsa05152            Pathway Map 
Hepatitis C hsa05160            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Measles hsa05162            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Influenza A hsa05164            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Herpes simplex virus 1 infection hsa05168            Pathway Map 
Epstein-Barr virus infection hsa05169            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
Platinum drug resistance hsa01524            Pathway Map 
MAPK signaling pathway hsa04010            Pathway Map 
p53 signaling pathway hsa04115            Pathway Map 
Apoptosis hsa04210            Pathway Map 
Apoptosis - multiple species hsa04215            Pathway Map 
TNF signaling pathway hsa04668            Pathway Map 
Serotonergic synapse hsa04726            Pathway Map 
Non-alcoholic fatty liver disease hsa04932            Pathway Map 
AGE-RAGE signaling pathway in diabetic complications hsa04933            Pathway Map 
Alcoholic liver disease hsa04936            Pathway Map 
Alzheimer disease hsa05010            Pathway Map 
Parkinson disease hsa05012            Pathway Map 
Amyotrophic lateral sclerosis hsa05014            Pathway Map 
Huntington disease hsa05016            Pathway Map 
Prion disease hsa05020            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Colorectal cancer hsa05210            Pathway Map 
Small cell lung cancer hsa05222            Pathway Map 
Viral myocarditis hsa05416            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
  3D Structure
PDB ID: 1CP3 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Epstein Barr virus 3'UTR RNA Info High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 24 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
CELECOXIB . 2662  D03RTS  DGIdb
CHEMBL312032 . 2815701  D0I2DF  DGIdb
CHEMBL378903 . 821478  D08WEV  DGIdb
DIACEREIN . 26248  D0N1FS  DGIdb
diacerein . 26248  D0N1FS  DrugCentral
EMRICASAN . 12000240  D04NAQ  DGIdb
IPRIFLAVONE . 3747  D0R2OA  DGIdb
NAPHTHOQUINONE . 8530  D0DQ6Z  DGIdb
PAC-1 . 135421197  D01YIF  DGIdb
PACLITAXEL . . . DGIdb
SPERMINE . 1103  D0LD9S  DGIdb
STAUROSPORINE . 44259  D0E3TC  DGIdb
WITHAFERIN A . 265237  D0V3PN  DGIdb

Protein Sequence Information

MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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