Host Protein General Information

  Protein Name
Serine/threonine-protein kinase PAK 4
  Gene Name
PAK4
  Host Species
Homo sapiens
  Uniprot Entry Name
PAK4_HUMAN
  Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  EC Number
2.7.11.1
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
10298
Uniprot ID
O96013
Ensembl ID
ENSG00000130669
HGNC ID
16059
  Related KEGG Pathway
T cell receptor signaling pathway hsa04660            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Renal cell carcinoma hsa05211            Pathway Map 
Regulation of actin cytoskeleton hsa04810            Pathway Map 
Focal adhesion hsa04510            Pathway Map 
Axon guidance hsa04360            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
Ras signaling pathway hsa04014            Pathway Map 
  3D Structure
PDB ID: 2BVA 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ADAVOSERTIB . 24856436  D02KKA  DGIdb
ALSTERPAULLONE . 5005498  D0H3EV  DGIdb
axitinib . 6450551  D01ZRI  DrugCentral
CYC-116 . 6420138  D0CY1B  DGIdb
DOVITINIB . 135611162  D07OZR  DGIdb
fedratinib . 16722836  D0G8BM  DrugCentral
GO-6976 . 3501  D08JPU  DGIdb
GSK-690693 . 16725726  D0MS3Z  DGIdb
JNJ-7706621 . 5330790  D04NGS  DGIdb
KPT-9274 . 117779453  D04ZQB  DGIdb
nintedanib . 135423438  D09HNV  DrugCentral
PALBOCICLIB . 5330286  D00UZR  DGIdb
PD-0166285 . 5311382  D0H8KG  DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
R-406 . 11213558  D0S6TK  DGIdb
ruxolitinib . 25126798  D04LKS  DrugCentral
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb
TOZASERTIB . 5494449  D02XNW  DGIdb

Protein Sequence Information

MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
    Click to Show/Hide