Host Protein General Information

  Protein Name
Retinoblastoma-associated protein
  Gene Name
RB1
  Host Species
Homo sapiens
  Uniprot Entry Name
RB_HUMAN
  Protein Families
Retinoblastoma protein (RB) family
  Subcellular Location
Nucleus
  External Link
NCBI Gene ID
5925
Uniprot ID
P06400
Ensembl ID
ENSG00000139687
HGNC ID
9884
  Related KEGG Pathway
Hepatitis C hsa05160            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Human T-cell leukemia virus 1 infection hsa05166            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Epstein-Barr virus infection hsa05169            Pathway Map 
Endocrine resistance hsa01522            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
Chemical carcinogenesis - receptor activation hsa05207            Pathway Map 
Pancreatic cancer hsa05212            Pathway Map 
Glioma hsa05214            Pathway Map 
Prostate cancer hsa05215            Pathway Map 
Melanoma hsa05218            Pathway Map 
Bladder cancer hsa05219            Pathway Map 
Chronic myeloid leukemia hsa05220            Pathway Map 
Small cell lung cancer hsa05222            Pathway Map 
Non-small cell lung cancer hsa05223            Pathway Map 
Breast cancer hsa05224            Pathway Map 
Hepatocellular carcinoma hsa05225            Pathway Map 
Gastric cancer hsa05226            Pathway Map 
Cell cycle hsa04110            Pathway Map 
Cellular senescence hsa04218            Pathway Map 
Cushing syndrome hsa04934            Pathway Map 
  3D Structure
PDB ID: 1AD6 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 0.0510338779360245 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h P = 0.0273226330161557 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h P = 0.00279411396197359 .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ALPELISIB . 56649450  D0W7HE  DGIdb
BORTEZOMIB . 387447  D0SH3I  DGIdb
DEXAMETHASONE . 5743  D0IT2G  DGIdb
ENTINOSTAT . 4261  D0M8FD  DGIdb
EVEROLIMUS . 6442177  D0K3QS  DGIdb
FOSTAMATINIB . 11671467  D0V8HJ  DGIdb
LARGAZOLE . 24757913  D0Z8PX  DGIdb
LORLATINIB . 71731823  D0AF6O  DGIdb
MERCAPTOPURINE . 667490  D09UZO  DGIdb
METHOTREXATE . 126941  D0SV8E  DGIdb
PALBOCICLIB . 5330286  D00UZR  DGIdb
PICTILISIB . 17755052  D08QGT  DGIdb
PREDNISOLONE . 5755  D0D1SG  DGIdb
RIBOCICLIB . 44631912  D08MXP  DGIdb
SAPANISERTIB . 45375953  D03DPZ  DGIdb
SELICICLIB . 160355  D05ADP  DGIdb
SIROLIMUS . 5284616  D03LJR  DGIdb
TOPOTECAN . 60700  D02PMO  DGIdb
TRAMETINIB . 11707110  D04XVN  DGIdb
TRILACICLIB . 68029831  D0AP9E  DGIdb
VORINOSTAT . 5311  D0E7PQ  DGIdb

Protein Sequence Information

MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMDTSNKEEK
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