Host Protein General Information

  Protein Name
Serine protease 1
  Gene Name
PRSS1
  Host Species
Homo sapiens
  Uniprot Entry Name
TRY1_HUMAN
  Protein Families
Peptidase S1 family
  EC Number
3.4.21.4
  Subcellular Location
Secreted; extracellular space
  External Link
NCBI Gene ID
5644
Uniprot ID
P07477
Ensembl ID
ENSG00000204983
HGNC ID
9475
  Related KEGG Pathway
Influenza A hsa05164            Pathway Map 
Pancreatic secretion hsa04972            Pathway Map 
Protein digestion and absorption hsa04974            Pathway Map 
Neuroactive ligand-receptor interaction hsa04080            Pathway Map 
  3D Structure
PDB ID: 1FXY 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Ebola virus (strain VeroVP30) 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5.1 Cells (Human hepatocellular carcinoma cell) . Liver . MIST = 0.68552462 .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/Not Specified Virus Strain) Not Specified Virus Region RNA Info RNAantisensepurificationandquantitativemassspectrometry(RAP-MS); Tandemmasstag(TMT)labelling; liquidchromatographycoupledwithtandemmassspectrometry(LC-MS/MS); Westernblot Huh7 cells (liver carcinoma celll ine) . Liver 24h log2 fold change = 4.60951E+14 .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/IPBCAMS-YL01/2020) 3'UTR RNA Info ChIRP-MS Huh7.5.1 cells . Liver 30 h MIST = 0.685033696 .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
BORTEZOMIB . 387447  D0SH3I  DGIdb
CAMOSTAT . 2536  D0Y6SQ  DGIdb
camostat . 2536  D0Y6SQ  DrugCentral
hexamidine . . . DrugCentral
MELAGATRAN . 183797  D01MUU  DGIdb
NAFAMOSTAT . 4413  D07XHO  DGIdb
nafamostat . 4413  D07XHO  DrugCentral
pentamidine . 4735  D05EAM  DrugCentral
propamidine . . . DrugCentral
ULINASTATIN . 105102  D0DF1R  DGIdb

Protein Sequence Information

MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
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