Host Protein General Information

  Protein Name
Polyunsaturated fatty acid 5-lipoxygenase
  Gene Name
ALOX5
  Host Species
Homo sapiens
  Uniprot Entry Name
LOX5_HUMAN
  Protein Families
Lipoxygenase family
  EC Number
1.13.11.-; 1.13.11.34
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
240
Uniprot ID
P09917
Ensembl ID
ENSG00000012779
HGNC ID
435
  Related KEGG Pathway
Fc epsilon RI signaling pathway hsa04664            Pathway Map 
Toxoplasmosis hsa05145            Pathway Map 
Ovarian steroidogenesis hsa04913            Pathway Map 
Metabolic pathways hsa01100            Pathway Map 
Arachidonic acid metabolism hsa00590            Pathway Map 
Serotonergic synapse hsa04726            Pathway Map 
  3D Structure
PDB ID: 3O8Y 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
5-OXO-ETE . 5283159  D0US4S  DGIdb
ACACETIN . 5280442  D0NS1S  DGIdb
ATRELEUTON . 3086671  D08PXR  DGIdb
auranofin . 24199313  D0L2UN  DrugCentral
BALSALAZIDE . 54585  D0A6KR  DGIdb
balsalazide . 54585  D0A6KR  DrugCentral
BALSALAZIDE DISODIUM . 54585  D0A6KR  DGIdb
benoxaprofen . 39941  D00CCI  DrugCentral
capsaicin . 1548943  D0U5CE  DrugCentral
chloroxine . 2722  D02HWP  DrugCentral
DARBUFELONE . 6444826  D0AL8T  DGIdb
DIETHYLCARBAMAZINE . 3052  D06RCB  DGIdb
diethylcarbamazine . 3052  D06RCB  DrugCentral
enoxolone . . . DrugCentral
eugenol . 3314  D0O4QB  DrugCentral
gentisic acid . . . DrugCentral
hexylresorcinol . 3610  D07EGB  DrugCentral
ibuprofen . 3672  D0R1QE  DrugCentral
LICOFELONE . 133021  D0N1SU  DGIdb
masoprocol . 71398  D0U3YB  DrugCentral
MECLOFENAMATE SODIUM . 4038  D0MN9K  DGIdb
meclofenamic acid . 4037  D08IFL  DrugCentral
MELATONIN . 896  D0AN7B  DGIdb
MESALAMINE . 4075  D0C4YC  DGIdb
mesalazine . 4075  D0C4YC  DrugCentral
METHOTREXATE . 126941  D0SV8E  DGIdb
mezlocillin . 656511  D00NJJ  DrugCentral
mizolastine . 65906  D06MAJ  DrugCentral
MONTELUKAST . 5281040  D00QET  DGIdb
montelukast . 5281040  D00QET  DrugCentral
olsalazine . 22419  D00KRE  DrugCentral
OLSALAZINE SODIUM . 22419  D00KRE  DGIdb
PF-4191834 . 24986635  D0L5XG  DGIdb
quercetin . 5280343  D0K8KX  DrugCentral
RILOPIROX . 71778  D00RJB  DGIdb
SILYBIN A . 31553  D02ADM  DGIdb
SULFASALAZINE . 5339  D02ZTJ  DGIdb
sulfasalazine . 5339  D02ZTJ  DrugCentral
TENIDAP . 60712  D02RQT  DGIdb
TEPOXALIN . 59757  D04WMR  DGIdb
TIPELUKAST . 9893228  D0Q7UG  DGIdb
ZILEUTON . 60490  D09JUG  DGIdb
zileuton . 60490  D09JUG  DrugCentral

Protein Sequence Information

MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI
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