Host Protein General Information

  Protein Name
Perforin-1
  Gene Name
PRF1
  Host Species
Homo sapiens
  Uniprot Entry Name
PERF_HUMAN
  Protein Families
Complement C6/C7/C8/C9 family
  Subcellular Location
Cytolytic granule
  External Link
NCBI Gene ID
5551
Uniprot ID
P14222
Ensembl ID
ENSG00000158435
HGNC ID
9360
  Related KEGG Pathway
Natural killer cell mediated cytotoxicity hsa04650            Pathway Map 
Autoimmune thyroid disease hsa05320            Pathway Map 
Allograft rejection hsa05330            Pathway Map 
Graft-versus-host disease hsa05332            Pathway Map 
Apoptosis hsa04210            Pathway Map 
Type I diabetes mellitus hsa04940            Pathway Map 
Viral myocarditis hsa05416            Pathway Map 
  3D Structure
AlphaFold ID: P14222 
  2D PNG Download  
  mmCIF File Download   
  PDB File Download   

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver . . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ALDESLEUKIN . ?  D05PUD  DGIdb
EMAPALUMAB . ?  D0UI7K  DGIdb

Protein Sequence Information

MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
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