Host Protein General Information

  Protein Name
Protein kinase C alpha type
  Gene Name
PRKCA
  Host Species
Homo sapiens
  Uniprot Entry Name
KPCA_HUMAN
  Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
  EC Number
2.7.11.13
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
5578
Uniprot ID
P17252
Ensembl ID
ENSG00000145734
HGNC ID
9393
  Related KEGG Pathway
Neutrophil extracellular trap formation hsa04613            Pathway Map 
Natural killer cell mediated cytotoxicity hsa04650            Pathway Map 
Fc epsilon RI signaling pathway hsa04664            Pathway Map 
Fc gamma R-mediated phagocytosis hsa04666            Pathway Map 
Leukocyte transendothelial migration hsa04670            Pathway Map 
Vibrio cholerae infection hsa05110            Pathway Map 
African trypanosomiasis hsa05143            Pathway Map 
Amoebiasis hsa05146            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Influenza A hsa05164            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
Coronavirus disease - COVID-19 hsa05171            Pathway Map 
EGFR tyrosine kinase inhibitor resistance hsa01521            Pathway Map 
MAPK signaling pathway hsa04010            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
Ras signaling pathway hsa04014            Pathway Map 
Rap1 signaling pathway hsa04015            Pathway Map 
Calcium signaling pathway hsa04020            Pathway Map 
HIF-1 signaling pathway hsa04066            Pathway Map 
Phosphatidylinositol signaling system hsa04070            Pathway Map 
Sphingolipid signaling pathway hsa04071            Pathway Map 
Phospholipase D signaling pathway hsa04072            Pathway Map 
mTOR signaling pathway hsa04150            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
Adrenergic signaling in cardiomyocytes hsa04261            Pathway Map 
Vascular smooth muscle contraction hsa04270            Pathway Map 
Wnt signaling pathway hsa04310            Pathway Map 
Axon guidance hsa04360            Pathway Map 
VEGF signaling pathway hsa04370            Pathway Map 
Focal adhesion hsa04510            Pathway Map 
Gap junction hsa04540            Pathway Map 
Circadian entrainment hsa04713            Pathway Map 
Long-term potentiation hsa04720            Pathway Map 
Retrograde endocannabinoid signaling hsa04723            Pathway Map 
Glutamatergic synapse hsa04724            Pathway Map 
Cholinergic synapse hsa04725            Pathway Map 
Serotonergic synapse hsa04726            Pathway Map 
GABAergic synapse hsa04727            Pathway Map 
Dopaminergic synapse hsa04728            Pathway Map 
Long-term depression hsa04730            Pathway Map 
Inflammatory mediator regulation of TRP channels hsa04750            Pathway Map 
Insulin secretion hsa04911            Pathway Map 
GnRH signaling pathway hsa04912            Pathway Map 
Melanogenesis hsa04916            Pathway Map 
Thyroid hormone synthesis hsa04918            Pathway Map 
Thyroid hormone signaling pathway hsa04919            Pathway Map 
Oxytocin signaling pathway hsa04921            Pathway Map 
Aldosterone synthesis and secretion hsa04925            Pathway Map 
Relaxin signaling pathway hsa04926            Pathway Map 
Parathyroid hormone synthesis, secretion and action hsa04928            Pathway Map 
GnRH secretion hsa04929            Pathway Map 
AGE-RAGE signaling pathway in diabetic complications hsa04933            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
Aldosterone-regulated sodium reabsorption hsa04960            Pathway Map 
Endocrine and other factor-regulated calcium reabsorption hsa04961            Pathway Map 
Salivary secretion hsa04970            Pathway Map 
Gastric acid secretion hsa04971            Pathway Map 
Pancreatic secretion hsa04972            Pathway Map 
Spinocerebellar ataxia hsa05017            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
Amphetamine addiction hsa05031            Pathway Map 
Morphine addiction hsa05032            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Chemical carcinogenesis - receptor activation hsa05207            Pathway Map 
Glioma hsa05214            Pathway Map 
Non-small cell lung cancer hsa05223            Pathway Map 
Hepatocellular carcinoma hsa05225            Pathway Map 
Choline metabolism in cancer hsa05231            Pathway Map 
Diabetic cardiomyopathy hsa05415            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
  3D Structure
PDB ID: 2ELI 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
BALANOL . 5287736  D0R2TM  DGIdb
BEVACIZUMAB . . D04KBL  DGIdb
CEP-2563 . . D0KX1E  DGIdb
CI-1040 . 6918454  D0B9BU  DGIdb
dequalinium . 2993  D0I2FI  DrugCentral
DIMETHYLSPINGOSINE . 5282309  D0M9DT  DGIdb
ENOXOLONE . . . DGIdb
ENZASTAURIN . 176167  D0I6VU  DGIdb
GSK-690693 . 16725726  D0MS3Z  DGIdb
HYDROCHLOROTHIAZIDE . 3639  D0U4UQ  DGIdb
ingenol mebutate . 6918670  D0E9KA  DrugCentral
ingenol mebutate . 6918670  D0E9KA  .
MIDOSTAURIN . 9829523  D07NVU  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
QUERCETIN . 5280343  D0K8KX  DGIdb
RESVERATROL . 445154  D0U3EP  DGIdb
RUBOXISTAURIN . 153999  D0W3LI  DGIdb
ruboxistaurin . 153999  D0W3LI  DrugCentral
sunitinib . 5329102  D0R0MW  DrugCentral
TRISMETHOXYRESVERATROL . 5388063  D0O9NE  DGIdb
UCN-01 . 72271  D0Z9VY  DGIdb

Protein Sequence Information

MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
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