Host Protein General Information

  Protein Name
Phospholipase C-II
  Gene Name
PLCG1
  Host Species
Homo sapiens
  Uniprot Entry Name
PLCG1_HUMAN
  EC Number
3.1.4.11
  Subcellular Location
Cell projection; lamellipodium
  External Link
NCBI Gene ID
5335
Uniprot ID
P19174
Ensembl ID
ENSG00000124181
HGNC ID
9065
  Related KEGG Pathway
Chemokine signaling pathway hsa04062            Pathway Map 
Neutrophil extracellular trap formation hsa04613            Pathway Map 
Natural killer cell mediated cytotoxicity hsa04650            Pathway Map 
Th1 and Th2 cell differentiation hsa04658            Pathway Map 
Th17 cell differentiation hsa04659            Pathway Map 
T cell receptor signaling pathway hsa04660            Pathway Map 
Fc epsilon RI signaling pathway hsa04664            Pathway Map 
Fc gamma R-mediated phagocytosis hsa04666            Pathway Map 
Leukocyte transendothelial migration hsa04670            Pathway Map 
Vibrio cholerae infection hsa05110            Pathway Map 
Epithelial cell signaling in Helicobacter pylori infection hsa05120            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
Coronavirus disease - COVID-19 hsa05171            Pathway Map 
EGFR tyrosine kinase inhibitor resistance hsa01521            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Choline metabolism in cancer hsa05231            Pathway Map 
PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235            Pathway Map 
Glioma hsa05214            Pathway Map 
Non-small cell lung cancer hsa05223            Pathway Map 
Hepatocellular carcinoma hsa05225            Pathway Map 
Inositol phosphate metabolism hsa00562            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Axon guidance hsa04360            Pathway Map 
AGE-RAGE signaling pathway in diabetic complications hsa04933            Pathway Map 
Thyroid hormone signaling pathway hsa04919            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
Metabolic pathways hsa01100            Pathway Map 
Neurotrophin signaling pathway hsa04722            Pathway Map 
Parkinson disease hsa05012            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
Inflammatory mediator regulation of TRP channels hsa04750            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
Ras signaling pathway hsa04014            Pathway Map 
Rap1 signaling pathway hsa04015            Pathway Map 
Calcium signaling pathway hsa04020            Pathway Map 
NF-kappa B signaling pathway hsa04064            Pathway Map 
HIF-1 signaling pathway hsa04066            Pathway Map 
Phosphatidylinositol signaling system hsa04070            Pathway Map 
Phospholipase D signaling pathway hsa04072            Pathway Map 
VEGF signaling pathway hsa04370            Pathway Map 
  3D Structure
PDB ID: 1HSQ 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h P = 0.0590680899981436 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 0.0465317995661615 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h P = 0.00154551109133323 .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
9,10-PHENANTHRENEQUINONE . 6763  D0Q2YJ  DGIdb
ACETAMINOPHEN . 1983  D0U5QK  DGIdb
ASPIRIN . 2244  D0GY5Z  DGIdb
CEFIXIME . 5362065  D06OVY  DGIdb
cefixime . 5362065  D06OVY  DrugCentral
DICLOFENAC . 3033  D0TG1H  DGIdb
PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER . 92199  D0O9GJ  DGIdb

Protein Sequence Information

MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
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