Host Protein General Information

  Protein Name
G protein-coupled receptor kinase 4
  Gene Name
GRK4
  Host Species
Homo sapiens
  Uniprot Entry Name
GRK4_HUMAN
  Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
  EC Number
2.7.11.16
  Subcellular Location
Cytoplasm; Cytoplasm
  External Link
NCBI Gene ID
2868
Uniprot ID
P32298
Ensembl ID
ENSG00000125388
HGNC ID
4543
  Related KEGG Pathway
Chemokine signaling pathway hsa04062            Pathway Map 
Morphine addiction hsa05032            Pathway Map 
Endocytosis hsa04144            Pathway Map 
  3D Structure
PDB ID: 4YHJ 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver . . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ATENOLOL . 2249  D01UXC  DGIdb
axitinib . 6450551  D01ZRI  DrugCentral
BALANOL . 5287736  D0R2TM  DGIdb
bosutinib . 5328940  D0OB0F  DrugCentral
crizotinib . 11626560  D03ZBT  DrugCentral
erlotinib . 176870  D07POC  DrugCentral
fedratinib . 16722836  D0G8BM  DrugCentral
METOPROLOL . 4171  D0I2MK  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
nintedanib . 135423438  D09HNV  DrugCentral
ruboxistaurin . 153999  D0W3LI  DrugCentral
ruxolitinib . 25126798  D04LKS  DrugCentral
sunitinib . 5329102  D0R0MW  DrugCentral
VERAPAMIL . 2520  D0R0FE  DGIdb

Protein Sequence Information

MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
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