Host Protein General Information

  Protein Name
Mitogen-activated protein kinase 9
  Gene Name
MAPK9
  Host Species
Homo sapiens
  Uniprot Entry Name
MK09_HUMAN
  Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
  EC Number
2.7.11.24
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
5601
Uniprot ID
P45984
Ensembl ID
ENSG00000050748
HGNC ID
6886
  Related KEGG Pathway
Toll-like receptor signaling pathway hsa04620            Pathway Map 
NOD-like receptor signaling pathway hsa04621            Pathway Map 
RIG-I-like receptor signaling pathway hsa04622            Pathway Map 
C-type lectin receptor signaling pathway hsa04625            Pathway Map 
IL-17 signaling pathway hsa04657            Pathway Map 
Th1 and Th2 cell differentiation hsa04658            Pathway Map 
Th17 cell differentiation hsa04659            Pathway Map 
T cell receptor signaling pathway hsa04660            Pathway Map 
Fc epsilon RI signaling pathway hsa04664            Pathway Map 
Epithelial cell signaling in Helicobacter pylori infection hsa05120            Pathway Map 
Pathogenic Escherichia coli infection hsa05130            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Salmonella infection hsa05132            Pathway Map 
Pertussis hsa05133            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Tuberculosis hsa05152            Pathway Map 
Chagas disease hsa05142            Pathway Map 
Toxoplasmosis hsa05145            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Measles hsa05162            Pathway Map 
Human T-cell leukemia virus 1 infection hsa05166            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Epstein-Barr virus infection hsa05169            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
Coronavirus disease - COVID-19 hsa05171            Pathway Map 
Endocrine resistance hsa01522            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Chemical carcinogenesis - reactive oxygen species hsa05208            Pathway Map 
Choline metabolism in cancer hsa05231            Pathway Map 
Colorectal cancer hsa05210            Pathway Map 
Pancreatic cancer hsa05212            Pathway Map 
Diabetic cardiomyopathy hsa05415            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Fluid shear stress and atherosclerosis hsa05418            Pathway Map 
Apoptosis hsa04210            Pathway Map 
Apoptosis - multiple species hsa04215            Pathway Map 
Necroptosis hsa04217            Pathway Map 
Focal adhesion hsa04510            Pathway Map 
Tight junction hsa04530            Pathway Map 
Osteoclast differentiation hsa04380            Pathway Map 
Type II diabetes mellitus hsa04930            Pathway Map 
Insulin resistance hsa04931            Pathway Map 
Non-alcoholic fatty liver disease hsa04932            Pathway Map 
AGE-RAGE signaling pathway in diabetic complications hsa04933            Pathway Map 
Alcoholic liver disease hsa04936            Pathway Map 
Insulin signaling pathway hsa04910            Pathway Map 
GnRH signaling pathway hsa04912            Pathway Map 
Progesterone-mediated oocyte maturation hsa04914            Pathway Map 
Prolactin signaling pathway hsa04917            Pathway Map 
Adipocytokine signaling pathway hsa04920            Pathway Map 
Relaxin signaling pathway hsa04926            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
Protein processing in endoplasmic reticulum hsa04141            Pathway Map 
Neurotrophin signaling pathway hsa04722            Pathway Map 
Retrograde endocannabinoid signaling hsa04723            Pathway Map 
Dopaminergic synapse hsa04728            Pathway Map 
Alzheimer disease hsa05010            Pathway Map 
Parkinson disease hsa05012            Pathway Map 
Huntington disease hsa05016            Pathway Map 
Spinocerebellar ataxia hsa05017            Pathway Map 
Prion disease hsa05020            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
Inflammatory mediator regulation of TRP channels hsa04750            Pathway Map 
MAPK signaling pathway hsa04010            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
Ras signaling pathway hsa04014            Pathway Map 
cAMP signaling pathway hsa04024            Pathway Map 
FoxO signaling pathway hsa04068            Pathway Map 
Sphingolipid signaling pathway hsa04071            Pathway Map 
Wnt signaling pathway hsa04310            Pathway Map 
TNF signaling pathway hsa04668            Pathway Map 
Mitophagy - animal hsa04137            Pathway Map 
Autophagy - animal hsa04140            Pathway Map 
  3D Structure
PDB ID: 3E7O 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver . . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
afatinib . 10184653  D05UFG  DrugCentral
CAMPTOTHECIN . 24360  D09YDM  DGIdb
CC-401 . 10430360  D04UUD  DGIdb
CHEMBL210618 . 11624601  D00HVA  DGIdb
CHEMBL406845 . ?  D06CIJ  DGIdb
CYC-116 . 6420138  D0CY1B  DGIdb
DORAMAPIMOD . 156422  D05CDF  DGIdb
erlotinib . 176870  D07POC  DrugCentral
fedratinib . 16722836  D0G8BM  DrugCentral
furaltadone . . . DrugCentral
GEFITINIB . 123631  D09XZB  DGIdb
gefitinib . 123631  D09XZB  DrugCentral
GO-6976 . 3501  D08JPU  DGIdb
imatinib . 5291  D0AZ3C  DrugCentral
LINIFANIB . 11485656  D0M9QZ  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
nilotinib . 644241  D00STL  DrugCentral
PALBOCICLIB . 5330286  D00UZR  DGIdb
PAMAPIMOD . 16220188  D04WCI  DGIdb
PAZOPANIB . . . DGIdb
PD-0166285 . 5311382  D0H8KG  DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
R-1487 . 11406590  D04YHW  DGIdb
R-406 . 11213558  D0S6TK  DGIdb
RGB-286638 . 11285001  D03DKV  DGIdb
SB-202190 . 5169  D0VC0I  DGIdb
SB-203580 . 176155  D0F8DL  DGIdb
SB-220025 . 5164  D09ICC  DGIdb
SORAFENIB . 216239  D0W5HK  DGIdb
sorafenib . 216239  D0W5HK  DrugCentral
SP-600125 . 8515  D02PVB  DGIdb
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb
TAK-715 . 9952773  D0O6ZO  DGIdb
TANZISERTIB . 11597537  D0X4MN  DGIdb

Protein Sequence Information

MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
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