Host Protein General Information

  Protein Name
MAP kinase kinase 6
  Gene Name
MAP2K6
  Host Species
Homo sapiens
  Uniprot Entry Name
MP2K6_HUMAN
  Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
  EC Number
2.7.12.2
  Subcellular Location
Nucleus
  External Link
NCBI Gene ID
5608
Uniprot ID
P52564
Ensembl ID
ENSG00000108984
HGNC ID
6846
  Related KEGG Pathway
Toll-like receptor signaling pathway hsa04620            Pathway Map 
Fc epsilon RI signaling pathway hsa04664            Pathway Map 
Salmonella infection hsa05132            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Toxoplasmosis hsa05145            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Epstein-Barr virus infection hsa05169            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Fluid shear stress and atherosclerosis hsa05418            Pathway Map 
Cellular senescence hsa04218            Pathway Map 
Osteoclast differentiation hsa04380            Pathway Map 
Alcoholic liver disease hsa04936            Pathway Map 
GnRH signaling pathway hsa04912            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
Amyotrophic lateral sclerosis hsa05014            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
Inflammatory mediator regulation of TRP channels hsa04750            Pathway Map 
MAPK signaling pathway hsa04010            Pathway Map 
Rap1 signaling pathway hsa04015            Pathway Map 
TNF signaling pathway hsa04668            Pathway Map 
  3D Structure
PDB ID: 2Y8O 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver . . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
BINIMETINIB . 10288191  D0C4LF  DGIdb
bosutinib . 5328940  D0OB0F  DrugCentral
COBIMETINIB . . . DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
NEFLAMAPIMOD . 3038525  D02NNV  DGIdb
pazopanib . . . DrugCentral
ruboxistaurin . 153999  D0W3LI  DrugCentral
SELUMETINIB . 10127622  D0T5DP  DGIdb
STAUROSPORINE . 44259  D0E3TC  DGIdb
sunitinib . 5329102  D0R0MW  DrugCentral
TRAMETINIB . 11707110  D04XVN  DGIdb

Protein Sequence Information

MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
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