Host Protein General Information

  Protein Name
Serine/threonine-protein kinase PLK1
  Gene Name
PLK1
  Host Species
Homo sapiens
  Uniprot Entry Name
PLK1_HUMAN
  Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily
  EC Number
2.7.11.21
  Subcellular Location
Nucleus; Chromosome; centromere; kinetochore
  External Link
NCBI Gene ID
5347
Uniprot ID
P53350
Ensembl ID
ENSG00000083444
HGNC ID
9077
  Related KEGG Pathway
FoxO signaling pathway hsa04068            Pathway Map 
Cell cycle hsa04110            Pathway Map 
Oocyte meiosis hsa04114            Pathway Map 
Progesterone-mediated oocyte maturation hsa04914            Pathway Map 
  3D Structure
PDB ID: 1Q4K 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Zika virus 3'UTR RNA Info RNA-protein interaction detection (RaPID) HEK293 Cells (Human embryonic kidney cell) . Kidney 42 h Saint score = 0.92 .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ACITRETIN . 5284513  D05QDC  DGIdb
ACRIFLAVINE . 443101  D0N3NL  DGIdb
APOMORPHINE HYDROCHLORIDE HEMIHYDRATE . 107882  D01KYP  DGIdb
BENZBROMARONE . 2333  D0Z3DY  DGIdb
bosutinib . 5328940  D0OB0F  DrugCentral
CEFACLOR . 51039  D0PW7C  DGIdb
CEPHALOCHROMIN . 160115  D00MEV  DGIdb
CHEMBL125044 . 379338  D0F3VE  DGIdb
CHEMBL175266 . 72721  D0XU4Y  DGIdb
CHEMBL223575 . 83107  D05GWI  DGIdb
CHEMBL225519 . 11715767  D03DZO  DGIdb
CHEMBL24983 . 1609  D0F3CA  DGIdb
CHEMBL275311 . 5289501  D0G6JM  DGIdb
CHEMBL429095 . 262093  D0J1KH  DGIdb
CHEMBL467987 . 247304  D00PZE  DGIdb
CHEMBL602969 . 3124417  D0IK4V  DGIdb
CHLORPYRIFOS . 2730  D0M5ES  DGIdb
DIPYRIDAMOLE . 3108  D0F9GE  DGIdb
DISULFIRAM . 3117  D0X5SD  DGIdb
ELLAGIC ACID . 5281855  D0A1CM  DGIdb
EMBELIN . 3218  D05HSW  DGIdb
ERYTHROMYCIN . 12560  D02YIZ  DGIdb
fedratinib . 16722836  D0G8BM  DrugCentral
GSK-461364 . 15983966  D08RMJ  DGIdb
GSK-579289A . 16051023  D0X1RH  DGIdb
GW7647 . 3392731  D00TFA  DGIdb
HEXACHLOROPHENE . 3598  D0ZX2G  DGIdb
HMN-214 . 9888590  D0R7ID  DGIdb
IDARUBICIN HYDROCHLORIDE . 42890  D01XDL  DGIdb
INAMRINONE . 3035194  D0R6TI  DGIdb
LANSOPRAZOLE . 9578005  D06YYD  DGIdb
LITHOCHOLIC ACID . 9903  D04SLF  DGIdb
MK-1496 . 67313626  D05RGV  DGIdb
MYRICETIN . 5281672  D0T3PW  DGIdb
OLEIC ACID . 445639  D0A4EA  DGIdb
OLEOYL DOPAMINE . 5282106  D0M4IF  DGIdb
OMEPRAZOLE . 4594  D01XNB  DGIdb
ONVANSERTIB . 49792852  D03HUX  DGIdb
OXYPHENBUTAZONE . 4641  D06ZPS  DGIdb
OXYTETRACYCLINE . 54675779  D0J2NK  DGIdb
PENTOSALEN . 10212  D09ROW  DGIdb
PROTOPORPHYRIN . 4971  D0AF3A  DGIdb
PURPURIN . 6683  D0XJ7I  DGIdb
PURPUROGALLIN . 135403797  D0R7MJ  DGIdb
quercetin . 5280343  D0K8KX  DrugCentral
RIGOSERTIB . 6918736  D0KF9Q  DGIdb
ruxolitinib . 25126798  D04LKS  DrugCentral
SENNOSIDE B . 91440  D09LBS  DGIdb
SIMVASTATIN . 54454  D0H0ND  DGIdb
STAVUDINE . 18283  D0Z8EX  DGIdb
TAE-684 . 16038120  D0R2WK  DGIdb
TAK-960 . 53357478  D09JGK  DGIdb
THIRAM . 5455  D02UVS  DGIdb
TOPOTECAN HYDROCHLORIDE . 60699  D0Z4XW  DGIdb
TRITIOZINE . . . DGIdb
VANITIOLIDE . . . DGIdb
VOLASERTIB . 10461508  D00BYM  DGIdb
WORTMANNIN . 312145  D0P1JI  DGIdb

Protein Sequence Information

MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
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