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| Strain Information | Strain Name |
Zika virus
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|---|---|---|---|---|---|---|---|---|---|
| Strain Family |
Flaviviridae
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| RNA Binding Site |
3'UTR
|
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| Virus Information | Virus Name |
Zika virus (ZIKV)
|
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| Taxonomy ID | 64320 | ||||||||
Full list of proteins interacting with the 3'UTR of this Strain
| Protein Name | Uniprot ID | Host Species | Pro Info | Detection Method | Infection Cell | Cell ID | Cell Originated Tissue | Infection Time | Interaction Score | Fold Change |
|---|---|---|---|---|---|---|---|---|---|---|
| Actin-binding protein WASF2 | Q9Y6W5 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.96 | FC = 6.41 |
| ATP-dependent RNA helicase DDX1 | Q92499 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 3.42 |
| ATP-dependent RNA helicase DHX38 | Q92620 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.9 | FC = 2.57 |
| Casein kinase I isoform alpha | P48729 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.91 | FC = 3.4 |
| Coiled-coil domain-containing protein 66 | A2RUB6 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 6.37 |
| CTTNBP2 N-terminal-like protein | Q9P2B4 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.97 | FC = 3.93 |
| Cyclin-A2 | P20248 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.94 | FC = 3.47 |
| Cyclin-dependent kinases regulatory subunit 2 | P33552 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.9 | FC = 2.87 |
| Deubiquitinating protein VCPIP1 | Q96JH7 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.93 | FC = 10.64 |
| Disco-interacting protein 2 homolog A | Q14689 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.91 | FC = 3.21 |
| DNA repair protein complementing XP-A cells | P23025 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.92 | FC = 3.1 |
| dUTPase | P33316 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.93 | FC = 3.14 |
| E3 ubiquitin-protein ligase RAD18 | Q9NS91 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 6.97 |
| Far upstream element-binding protein 3 | Q96I24 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 3.68 |
| GTPase-activating protein ZNF289 | Q8N6H7 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 5.38 |
| High mobility group protein HMG-I/HMG-Y | P17096 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.98 | FC = 3.87 |
| Human cervical cancer suppressor gene 4 protein | Q9NYL2 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.96 | FC = 8.4 |
| Intraflagellar transport protein 74 homolog | Q96LB3 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 9.78 |
| Leucine zipper transcription factor-like protein 1 | Q9NQ48 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 7.87 |
| N-alpha-acetyltransferase 30 | Q147X3 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.98 | FC = 2.9 |
| Peptidyl-prolyl cis-trans isomerase FKBP4 | Q02790 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.94 | FC = 15.86 |
| Probable ATP-dependent RNA helicase DDX49 | Q9Y6V7 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.92 | FC = 3.12 |
| Programmed cell death protein 4 | Q53EL6 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.92 | FC = 3.36 |
| Protein FAM107B | Q9H098 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.9 | FC = 2.73 |
| Ribosome-binding protein 1 | Q9P2E9 | Homo sapiens | Pro Info | Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) | HuH-7.5.1 Cells (Human hepatocellular carcinoma cell) | . | Liver | 48 h | . | FC = 4.2726342761382 |
| Serine/threonine-protein kinase PLK1 | P53350 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.92 | FC = 4.24 |
| Serine/threonine-protein kinase VRK1 | Q99986 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 3.96 |
| SH2 domain-containing adapter protein B | Q15464 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.96 | FC = 3.45 |
| Signal recognition particle subunit SRP54 | P61011 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.97 | FC = 5.94 |
| Sorting nexin-12 | Q9UMY4 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.97 | FC = 2.47 |
| Stress-induced-phosphoprotein 1 | P31948 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.98 | FC = 4.55 |
| Telomerase-binding protein EST1A | Q86US8 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.96 | FC = 4.67 |
| Tight junction protein ZO-2 | Q9UDY2 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.93 | FC = 2.58 |
| Ubiquitin carboxyl-terminal hydrolase 15 | Q9Y4E8 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 4.27 |
| Vinculin | P18206 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 5.28 |
| WAS/WASL-interacting protein family member 2 | Q8TF74 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 0.9 | FC = 3.49 |
| WD repeat-containing protein 44 | Q5JSH3 | Homo sapiens | Pro Info | RNA-protein interaction detection (RaPID) | HEK293 Cells (Human embryonic kidney cell) | . | Kidney | 42 h | Saint score = 1 | FC = 5.75 |
Functional Go Enrichment analysis of those proteins interacting with the 3'UTR of this Strain
| GO Term | GO Category | GO ID | Adjusted P-value | Odds Ratio | Combined Score |
|---|---|---|---|---|---|
| RNA Binding | Molecular Function |
GO:0003723
|
0.000481129 | 6.369349535 | 77.59568103 |
| DNA Secondary Structure Binding | Molecular Function |
GO:0000217
|
0.047745151 | 36.74101382 | 234.3909225 |
| Protein Kinase Binding | Molecular Function |
GO:0019901
|
0.047745151 | 6.008213933 | 36.32088253 |
| Magnesium Ion Binding | Molecular Function |
GO:0000287
|
0.047745151 | 11.5001935 | 67.10078777 |
| Damaged DNA Binding | Molecular Function |
GO:0003684
|
0.047745151 | 26.4717608 | 152.6066739 |
| Cyclin-Dependent Protein Serine/Threonine Kinase Regulator Activity | Molecular Function |
GO:0016538
|
0.047745151 | 25.86883117 | 148.0109909 |
| Protein Serine/Threonine Kinase Activity | Molecular Function |
GO:0004674
|
0.047745151 | 7.037833961 | 39.68819247 |
| 3'-5' RNA Helicase Activity | Molecular Function |
GO:0034458
|
0.079158354 | 138.6041667 | 649.6020692 |
| Kinase Binding | Molecular Function |
GO:0019900
|
0.079158354 | 5.185273791 | 23.87206722 |
| Peroxisome Proliferator Activated Receptor Binding | Molecular Function |
GO:0042975
|
0.079158354 | 110.8777778 | 499.5398568 |
| Minor Groove Of Adenine-Thymine-Rich DNA Binding | Molecular Function |
GO:0003680
|
0.079158354 | 110.8777778 | 499.5398568 |
| Peptide alpha-N-acetyltransferase Activity | Molecular Function |
GO:0004596
|
0.079158354 | 92.39351852 | 402.1028593 |
| Cysteine-Type Deubiquitinase Activity | Molecular Function |
GO:0004843
|
0.079158354 | 11.82559524 | 50.34694777 |
| Guanylate Kinase Activity | Molecular Function |
GO:0004385
|
0.079158354 | 79.19047619 | 334.1390606 |
| Peptide N-acetyltransferase Activity | Molecular Function |
GO:0034212
|
0.079158354 | 79.19047619 | 334.1390606 |
| Protein Kinase Regulator Activity | Molecular Function |
GO:0019887
|
0.079158354 | 11.23734088 | 46.78336048 |
| Histone H3 Kinase Activity | Molecular Function |
GO:0140996
|
0.079158354 | 69.28819444 | 284.2582964 |
| Small Ribosomal Subunit rRNA Binding | Molecular Function |
GO:0070181
|
0.079158354 | 69.28819444 | 284.2582964 |
| Nucleoside Triphosphate Diphosphatase Activity | Molecular Function |
GO:0047429
|
0.079158354 | 69.28819444 | 284.2582964 |
| Nuclear Retinoid X Receptor Binding | Molecular Function |
GO:0046965
|
0.079158354 | 61.58641975 | 246.2279154 |
| Nucleus | Cellular Component |
GO:0005634
|
0.001403635 | 4.081170413 | 42.77357629 |
| Intracellular Membrane-Bounded Organelle | Cellular Component |
GO:0043231
|
0.006008345 | 3.379471672 | 28.16276576 |
| Cyclin-Dependent Protein Kinase Holoenzyme Complex | Cellular Component |
GO:0000307
|
0.041416517 | 29.96240602 | 179.6991173 |
| Cell-Cell Contact Zone | Cellular Component |
GO:0044291
|
0.042700551 | 25.29269841 | 143.6441165 |
| Serine/Threonine Protein Kinase Complex | Cellular Component |
GO:1902554
|
0.047249161 | 19.61083744 | 102.0012327 |
| Intracellular Non-Membrane-Bounded Organelle | Cellular Component |
GO:0043232
|
0.047249161 | 3.687570146 | 19.07426604 |
| Signal Recognition Particle, Endoplasmic Reticulum Targeting | Cellular Component |
GO:0005786
|
0.065833275 | 138.6041667 | 649.6020692 |
| Cilium | Cellular Component |
GO:0005929
|
0.073805576 | 6.846572487 | 30.39126742 |
| Nuclear Inclusion Body | Cellular Component |
GO:0042405
|
0.101948305 | 61.58641975 | 246.2279154 |
| Cytoskeleton | Cellular Component |
GO:0005856
|
0.11400932 | 3.945607334 | 14.70261713 |
| Microtubule Cytoskeleton | Cellular Component |
GO:0015630
|
0.11400932 | 5.107756377 | 18.82516125 |
| Axonal Growth Cone | Cellular Component |
GO:0044295
|
0.114178301 | 39.58134921 | 142.3784815 |
| Microtubule | Cellular Component |
GO:0005874
|
0.176445412 | 6.176424668 | 19.03461289 |
| Golgi Stack | Cellular Component |
GO:0005795
|
0.19162197 | 18.45648148 | 53.25609733 |
| Spindle | Cellular Component |
GO:0005819
|
0.19162197 | 5.427197802 | 15.50118167 |
| Heterochromatin | Cellular Component |
GO:0000792
|
0.222833649 | 11.52488426 | 28.16338869 |
| Sarcolemma | Cellular Component |
GO:0042383
|
0.222833649 | 10.8453159 | 25.88717095 |
| Endoplasmic Reticulum Lumen | Cellular Component |
GO:0005788
|
0.222833649 | 3.98804458 | 9.31277719 |
| Extracellular Membrane-Bounded Organelle | Cellular Component |
GO:0065010
|
0.222833649 | 9.874503968 | 22.70716638 |
| Extracellular Vesicle | Cellular Component |
GO:1903561
|
0.222833649 | 9.370998117 | 21.09357381 |
| Mitotic Nuclear Membrane Disassembly | Biological Process |
GO:0007077
|
0.012366214 | 285.1285714 | 2825.382972 |
| Nuclear Membrane Disassembly | Biological Process |
GO:0051081
|
0.012366214 | 190.0666667 | 1765.211478 |
| Golgi Inheritance | Biological Process |
GO:0048313
|
0.012366214 | 162.9061224 | 1472.211648 |
| Regulation Of Protein Localization To Chromatin | Biological Process |
GO:1905634
|
0.012366214 | 162.9061224 | 1472.211648 |
| Peptidyl-Serine Phosphorylation | Biological Process |
GO:0018105
|
0.016815527 | 15.59149941 | 132.6322071 |
| Peptidyl-Serine Modification | Biological Process |
GO:0018209
|
0.016926272 | 14.81556304 | 123.233099 |
| Maintenance Of Blood-Brain Barrier | Biological Process |
GO:0035633
|
0.067844185 | 42.19259259 | 280.0589703 |
| Regulation Of Metaphase/Anaphase Transition Of Cell Cycle | Biological Process |
GO:1902099
|
0.067844185 | 37.96761905 | 244.5456874 |
| Golgi Organization | Biological Process |
GO:0007030
|
0.067844185 | 13.78138027 | 87.29823799 |
| Protein Modification Process | Biological Process |
GO:0036211
|
0.067844185 | 5.28702814 | 33.43628143 |
| DNA Repair | Biological Process |
GO:0006281
|
0.067844185 | 8.309998944 | 51.69899059 |
| Protein Phosphorylation | Biological Process |
GO:0006468
|
0.067844185 | 6.14520202 | 37.73007192 |
| G2/M Transition Of Mitotic Cell Cycle | Biological Process |
GO:0000086
|
0.067844185 | 31.63015873 | 192.9154451 |
| Negative Regulation Of Transport | Biological Process |
GO:0051051
|
0.067844185 | 30.77374517 | 186.1078265 |
| Cell Cycle G2/M Phase Transition | Biological Process |
GO:0044839
|
0.067844185 | 29.96240602 | 179.6991173 |
| DNA Duplex Unwinding | Biological Process |
GO:0032508
|
0.067844185 | 29.19267399 | 173.6566538 |
| Homotypic Cell-Cell Adhesion | Biological Process |
GO:0034109
|
0.080128499 | 25.86883117 | 148.0109909 |
| Regulation Of Mitotic Metaphase/Anaphase Transition | Biological Process |
GO:0030071
|
0.085687431 | 24.21398176 | 135.5344365 |
| Microtubule Bundle Formation | Biological Process |
GO:0001578
|
0.087807237 | 23.22332362 | 128.1662168 |
| DNA Damage Response | Biological Process |
GO:0006974
|
0.107560783 | 6.246570973 | 32.66414998 |
Virus RNA Sequence Information
|
>NC_012532.1 Zika virus, complete genome
AGTTGTTGATCTGTGTGAGTCAGACTGCGACAGTTCGAGTCTGAAGCGAGAGCTAACAACAGTATCAACA
GGTTTAATTTGGATTTGGAAACGAGAGTTTCTGGTCATGAAAAACCCCAAAGAAGAAATCCGGAGGATCC
GGATTGTCAATATGCTAAAACGCGGAGTAGCCCGTGTAAACCCCTTGGGAGGTTTGAAGAGGTTGCCAGC
CGGACTTCTGCTGGGTCATGGACCCATCAGAATGGTTTTGGCGATACTAGCCTTTTTGAGATTTACAGCA
ATCAAGCCATCACTGGGCCTTATCAACAGATGGGGTTCCGTGGGGAAAAAAGAGGCTATGGAAATAATAA
AGAAGTTCAAGAAAGATCTTGCTGCCATGTTGAGAATAATCAATGCTAGGAAAGAGAGGAAGAGACGTGG
CGCAGACACCAGCATCGGAATCATTGGCCTCCTGCTGACTACAGCCATGGCAGCAGAGATCACTAGACGC
GGGAGTGCATACTACATGTACTTGGATAGGAGCGATGCCGGGAAGGCCATTTCGTTTGCTACCACATTGG
GAGTGAACAAGTGCCACGTACAGATCATGGACCTCGGGCACATGTGTGACGCCACCATGAGTTATGAGTG
CCCTATGCTGGATGAGGGAGTGGAACCAGATGATGTCGATTGCTGGTGCAACACGACATCAACTTGGGTT
GTGTACGGAACCTGTCATCACAAAAAAGGTGAGGCACGGCGATCTAGAAGAGCCGTGACGCTCCCTTCTC
ACTCTACAAGGAAGTTGCAAACGCGGTCGCAGACCTGGTTAGAATCAAGAGAATACACGAAGCACTTGAT
CAAGGTTGAAAACTGGATATTCAGGAACCCCGGGTTTGCGCTAGTGGCCGTTGCCATTGCCTGGCTTTTG
GGAAGCTCGACGAGCCAAAAAGTCATATACTTGGTCATGATACTGCTGATTGCCCCGGCATACAGTATCA
GGTGCATTGGAGTCAGCAATAGAGACTTCGTGGAGGGCATGTCAGGTGGGACCTGGGTTGATGTTGTCTT
GGAACATGGAGGCTGCGTTACCGTGATGGCACAGGACAAGCCAACAGTCGACATAGAGTTGGTCACGACG
ACGGTTAGTAACATGGCCGAGGTAAGATCCTATTGCTACGAGGCATCGATATCGGACATGGCTTCGGACA
GTCGTTGCCCAACACAAGGTGAAGCCTACCTTGACAAGCAATCAGACACTCAATATGTCTGCAAAAGAAC
ATTAGTGGACAGAGGTTGGGGAAACGGTTGTGGACTTTTTGGCAAAGGGAGCTTGGTGACATGTGCCAAG
TTTACGTGTTCTAAGAAGATGACCGGGAAGAGCATTCAACCGGAAAATCTGGAGTATCGGATAATGCTAT
CAGTGCATGGCTCCCAGCATAGCGGGATGATTGGATATGAAACTGACGAAGATAGAGCGAAAGTCGAGGT
TACGCCTAATTCACCAAGAGCGGAAGCAACCTTGGGAGGCTTTGGAAGCTTAGGACTTGACTGTGAACCA
AGGACAGGCCTTGACTTTTCAGATCTGTATTACCTGACCATGAACAATAAGCATTGGTTGGTGCACAAAG
AGTGGTTTCATGACATCCCATTGCCTTGGCATGCTGGGGCAGACACCGGAACTCCACACTGGAACAACAA
AGAGGCATTGGTAGAATTCAAGGATGCCCACGCCAAGAGGCAAACCGTCGTCGTTCTGGGGAGCCAGGAA
GGAGCCGTTCACACGGCTCTCGCTGGAGCTCTAGAGGCTGAGATGGATGGTGCAAAGGGAAGGCTGTTCT
CTGGCCATTTGAAATGCCGCCTAAAAATGGACAAGCTTAGATTGAAGGGCGTGTCATATTCCTTGTGCAC
TGCGGCATTCACATTCACCAAGGTCCCAGCTGAAACACTGCATGGAACAGTCACAGTGGAGGTGCAGTAT
GCAGGGACAGATGGACCCTGCAAGATCCCAGTCCAGATGGCGGTGGACATGCAGACCCTGACCCCAGTTG
GAAGGCTGATAACCGCCAACCCCGTGATTACTGAAAGCACTGAGAACTCAAAGATGATGTTGGAGCTTGA
CCCACCATTTGGGGATTCTTACATTGTCATAGGAGTTGGGGACAAGAAAATCACCCACCACTGGCATAGG
AGTGGTAGCACCATCGGAAAGGCATTTGAGGCCACTGTGAGAGGCGCCAAGAGAATGGCAGTCCTGGGGG
ATACAGCCTGGGACTTCGGATCAGTCGGGGGTGTGTTCAACTCACTGGGTAAGGGCATTCACCAGATTTT
TGGAGCAGCCTTCAAATCACTGTTTGGAGGAATGTCCTGGTTCTCACAGATCCTCATAGGCACGCTGCTA
GTGTGGTTAGGTTTGAACACAAAGAATGGATCTATCTCCCTCACATGCTTGGCCCTGGGGGGAGTGATGA
TCTTCCTCTCCACGGCTGTTTCTGCTGACGTGGGGTGCTCAGTGGACTTCTCAAAAAAGGAAACGAGATG
TGGCACGGGGGTATTCATCTATAATGATGTTGAAGCCTGGAGGGACCGGTACAAGTACCATCCTGACTCC
CCCCGCAGATTGGCAGCAGCAGTCAAGCAGGCCTGGGAAGAGGGGATCTGTGGGATCTCATCCGTTTCAA
GAATGGAAAACATCATGTGGAAATCAGTAGAAGGGGAGCTCAATGCTATCCTAGAGGAGAATGGAGTTCA
ACTGACAGTTGTTGTGGGATCTGTAAAAAACCCCATGTGGAGAGGTCCACAAAGATTGCCAGTGCCTGTG
AATGAGCTGCCCCATGGCTGGAAAGCCTGGGGGAAATCGTATTTTGTTAGGGCGGCAAAGACCAACAACA
GTTTTGTTGTCGACGGTGACACACTGAAGGAATGTCCGCTTGAGCACAGAGCATGGAATAGTTTTCTTGT
GGAGGATCACGGGTTTGGAGTCTTCCACACCAGTGTCTGGCTTAAGGTCAGAGAAGATTACTCATTAGAA
TGTGACCCAGCCGTCATAGGAACAGCTGTTAAGGGAAGGGAGGCCGCGCACAGTGATCTGGGCTATTGGA
TTGAAAGTGAAAAGAATGACACATGGAGGCTGAAGAGGGCCCACCTGATTGAGATGAAAACATGTGAATG
GCCAAAGTCTCACACATTGTGGACAGATGGAGTAGAAGAAAGTGATCTTATCATACCCAAGTCTTTAGCT
GGTCCACTCAGCCACCACAACACCAGAGAGGGTTACAGAACCCAAGTGAAAGGGCCATGGCACAGTGAAG
AGCTTGAAATCCGGTTTGAGGAATGTCCAGGCACCAAGGTTTACGTGGAGGAGACATGCGGAACTAGAGG
ACCATCTCTGAGATCAACTACTGCAAGTGGAAGGGTCATTGAGGAATGGTGCTGTAGGGAATGCACAATG
CCCCCACTATCGTTTCGAGCAAAAGACGGCTGCTGGTATGGAATGGAGATAAGGCCCAGGAAAGAACCAG
AGAGCAACTTAGTGAGGTCAATGGTGACAGCGGGGTCAACCGATCATATGGACCACTTCTCTCTTGGAGT
GCTTGTGATTCTACTCATGGTGCAGGAGGGGTTGAAGAAGAGAATGACCACAAAGATCATCATGAGCACA
TCAATGGCAGTGCTGGTAGTCATGATCTTGGGAGGATTTTCAATGAGTGACCTGGCCAAGCTTGTGATCC
TGATGGGTGCTACTTTCGCAGAAATGAACACTGGAGGAGATGTAGCTCACTTGGCATTGGTAGCGGCATT
TAAAGTCAGACCAGCCTTGCTGGTCTCCTTCATTTTCAGAGCCAATTGGACACCCCGTGAGAGCATGCTG
CTAGCCCTGGCTTCGTGTCTTCTGCAAACTGCGATCTCTGCTCTTGAAGGTGACTTGATGGTCCTCATTA
ATGGATTTGCTTTGGCCTGGTTGGCAATTCGAGCAATGGCCGTGCCACGCACTGACAACATCGCTCTACC
AATCTTGGCTGCTCTAACACCACTAGCTCGAGGCACACTGCTCGTGGCATGGAGAGCGGGCCTGGCTACT
TGTGGAGGGATCATGCTCCTCTCCCTGAAAGGGAAAGGTAGTGTGAAGAAGAACCTGCCATTTGTCATGG
CCCTGGGATTGACAGCTGTGAGGGTAGTAGACCCTATTAATGTGGTAGGACTACTGTTACTCACAAGGAG
TGGGAAGCGGAGCTGGCCCCCTAGTGAAGTTCTCACAGCCGTTGGCCTGATATGTGCACTGGCCGGAGGG
TTTGCCAAGGCAGACATTGAGATGGCTGGACCCATGGCTGCAGTAGGCTTGCTAATTGTCAGCTATGTGG
TCTCGGGAAAGAGTGTGGACATGTACATTGAAAGAGCAGGTGACATCACATGGGAAAAGGACGCGGAAGT
CACTGGAAACAGTCCTCGGCTTGACGTGGCACTGGATGAGAGTGGTGACTTCTCCTTGGTAGAGGAAGAT
GGTCCACCCATGAGAGAGATCATACTCAAGGTGGTCCTGATGGCCATCTGTGGCATGAACCCAATAGCTA
TACCTTTTGCTGCAGGAGCGTGGTATGTGTATGTGAAGACTGGGAAAAGGAGTGGCGCCCTCTGGGACGT
GCCTGCTCCCAAAGAAGTGAAGAAAGGAGAGACCACAGATGGAGTGTACAGAGTGATGACTCGCAGACTG
CTAGGTTCAACACAGGTTGGAGTGGGAGTCATGCAAGAGGGAGTCTTCCACACCATGTGGCACGTTACAA
AAGGAGCCGCACTGAGGAGCGGTGAGGGAAGACTTGATCCATACTGGGGGGATGTCAAGCAGGACTTGGT
GTCATACTGTGGGCCTTGGAAGTTGGATGCAGCTTGGGATGGACTCAGCGAGGTACAGCTTTTGGCCGTA
CCTCCCGGAGAGAGGGCCAGAAACATTCAGACCCTGCCTGGAATATTCAAGACAAAGGACGGGGACATCG
GAGCAGTTGCTCTGGACTACCCTGCAGGGACCTCAGGATCTCCGATCCTAGACAAATGTGGAAGAGTGAT
AGGACTCTATGGCAATGGGGTTGTGATCAAGAATGGAAGCTATGTTAGTGCTATAACCCAGGGAAAGAGG
GAGGAGGAGACTCCGGTTGAATGTTTCGAACCCTCGATGCTGAAGAAGAAGCAGCTAACTGTCTTGGATC
TGCATCCAGGAGCCGGAAAAACCAGGAGAGTTCTTCCTGAAATAGTCCGTGAAGCCATAAAAAAGAGACT
CCGGACAGTGATCTTGGCACCAACTAGGGTTGTCGCTGCTGAGATGGAGGAGGCCTTGAGAGGACTTCCG
GTGCGTTACATGACAACAGCAGTCAACGTCACCCATTCTGGGACAGAAATCGTTGATTTGATGTGCCATG
CCACTTTCACTTCACGCTTACTACAACCCATCAGAGTCCCTAATTACAATCTCAACATCATGGATGAAGC
CCACTTCACAGACCCCTCAAGTATAGCTGCAAGAGGATACATATCAACAAGGGTTGAAATGGGCGAGGCG
GCTGCCATTTTTATGACTGCCACACCACCAGGAACCCGTGATGCGTTTCCTGACTCTAACTCACCAATCA
TGGACACAGAAGTGGAAGTCCCAGAGAGAGCCTGGAGCTCAGGCTTTGATTGGGTGACAGACCATTCTGG
GAAAACAGTTTGGTTCGTTCCAAGCGTGAGAAACGGAAATGAAATCGCAGCCTGTCTGACAAAGGCTGGA
AAGCGGGTCATACAGCTCAGCAGGAAGACTTTTGAGACAGAATTTCAGAAAACAAAAAATCAAGAGTGGG
ACTTTGTCATAACAACTGACATCTCAGAGATGGGCGCCAACTTCAAGGCTGACCGGGTCATAGACTCTAG
GAGATGCCTAAAACCAGTCATACTTGATGGTGAGAGAGTCATCTTGGCTGGGCCCATGCCTGTCACGCAT
GCTAGTGCTGCTCAGAGGAGAGGACGTATAGGCAGGAACCCTAACAAACCTGGAGATGAGTACATGTATG
GAGGTGGGTGTGCAGAGACTGATGAAGGCCATGCACACTGGCTTGAAGCAAGAATGCTTCTTGACAACAT
CTACCTCCAGGATGGCCTCATAGCCTCGCTCTATCGGCCTGAGGCCGATAAGGTAGCCGCCATTGAGGGA
GAGTTTAAGCTGAGGACAGAGCAAAGGAAGACCTTCGTGGAACTCATGAAGAGAGGAGACCTTCCCGTCT
GGCTAGCCTATCAGGTTGCATCTGCCGGAATAACTTACACAGACAGAAGATGGTGCTTTGATGGCACAAC
CAACAACACCATAATGGAAGACAGTGTACCAGCAGAGGTTTGGACAAAGTATGGAGAGAAGAGAGTGCTC
AAACCGAGATGGATGGATGCTAGGGTCTGTTCAGACCATGCGGCCCTGAAGTCGTTCAAAGAATTCGCCG
CTGGAAAAAGAGGAGCGGCTTTGGGAGTAATGGAGGCCCTGGGAACACTGCCAGGACACATGACAGAGAG
GTTTCAGGAAGCCATTGACAACCTCGCCGTGCTCATGCGAGCAGAGACTGGAAGCAGGCCTTATAAGGCA
GCGGCAGCCCAACTGCCGGAGACCCTAGAGACCATTATGCTCTTAGGTTTGCTGGGAACAGTTTCACTGG
GGATCTTCTTCGTCTTGATGCGGAATAAGGGCATCGGGAAGATGGGCTTTGGAATGGTAACCCTTGGGGC
CAGTGCATGGCTCATGTGGCTTTCGGAAATTGAACCAGCCAGAATTGCATGTGTCCTCATTGTTGTGTTT
TTATTACTGGTGGTGCTCATACCCGAGCCAGAGAAGCAAAGATCTCCCCAAGATAACCAGATGGCAATTA
TCATCATGGTGGCAGTGGGCCTTCTAGGTTTGATAACTGCAAACGAACTTGGATGGCTGGAAAGAACAAA
AAATGACATAGCTCATCTAATGGGAAGGAGAGAAGAAGGAGCAACCATGGGATTCTCAATGGACATTGAT
CTGCGGCCAGCCTCCGCCTGGGCTATCTATGCCGCATTGACAACTCTCATCACCCCAGCTGTCCAACATG
CGGTAACCACTTCATACAACAACTACTCCTTAATGGCGATGGCCACACAAGCTGGAGTGCTGTTTGGCAT
GGGCAAAGGGATGCCATTTATGCATGGGGACCTTGGAGTCCCGCTGCTAATGATGGGTTGCTATTCACAA
TTAACACCCCTGACTCTGATAGTAGCTATCATTCTGCTTGTGGCGCACTACATGTACTTGATCCCAGGCC
TACAAGCGGCAGCAGCGCGTGCTGCCCAGAAAAGGACAGCAGCTGGCATCATGAAGAATCCCGTTGTGGA
TGGAATAGTGGTAACTGACATTGACACAATGACAATAGACCCCCAGGTGGAGAAGAAGATGGGACAAGTG
TTACTCATAGCAGTAGCCATCTCCAGTGCTGTGCTGCTGCGGACCGCCTGGGGATGGGGGGAGGCTGGAG
CTCTGATCACAGCAGCGACCTCCACCTTGTGGGAAGGCTCTCCAAACAAATACTGGAACTCCTCTACAGC
CACCTCACTGTGCAACATCTTCAGAGGAAGCTATCTGGCAGGAGCTTCCCTTATCTATACAGTGACGAGA
AACGCTGGCCTGGTTAAGAGACGTGGAGGTGGGACGGGAGAGACTCTGGGAGAGAAGTGGAAAGCTCGTC
TGAATCAGATGTCGGCCCTGGAGTTCTACTCTTATAAAAAGTCAGGTATCACTGAAGTGTGTAGAGAGGA
GGCTCGCCGTGCCCTCAAGGATGGAGTGGCCACAGGAGGACATGCCGTATCCCGGGGAAGTGCAAAGATC
AGATGGTTGGAGGAGAGAGGATATCTGCAGCCCTATGGGAAGGTTGTTGACCTCGGATGTGGCAGAGGGG
GCTGGAGCTATTATGCCGCCACCATCCGCAAAGTGCAGGAGGTGAGAGGATACACAAAGGGAGGTCCCGG
TCATGAAGAACCCATGCTGGTGCAAAGCTATGGGTGGAACATAGTTCGTCTCAAGAGTGGAGTGGACGTC
TTCCACATGGCGGCTGAGCCGTGTGACACTCTGCTGTGTGACATAGGTGAGTCATCATCTAGTCCTGAAG
TGGAAGAGACACGAACACTCAGAGTGCTCTCTATGGTGGGGGACTGGCTTGAAAAAAGACCAGGGGCCTT
CTGTATAAAGGTGCTGTGCCCATACACCAGCACTATGATGGAAACCATGGAGCGACTGCAACGTAGGCAT
GGGGGAGGATTAGTCAGAGTGCCATTGTGTCGCAACTCCACACATGAGATGTACTGGGTCTCTGGGGCAA
AGAGCAACATCATAAAAAGTGTGTCCACCACAAGTCAGCTCCTCCTGGGACGCATGGATGGCCCCAGGAG
GCCAGTGAAATATGAGGAGGATGTGAACCTCGGCTCGGGTACACGAGCTGTGGCAAGCTGTGCTGAGGCT
CCTAACATGAAAATCATCGGCAGGCGCATTGAGAGAATCCGCAATGAACATGCAGAAACATGGTTTCTTG
ATGAAAACCACCCATACAGGACATGGGCCTACCATGGGAGCTACGAAGCCCCCACGCAAGGATCAGCGTC
TTCCCTCGTGAACGGGGTTGTTAGACTCCTGTCAAAGCCTTGGGACGTGGTGACTGGAGTTACAGGAATA
GCCATGACTGACACCACACCATACGGCCAACAAAGAGTCTTCAAAGAAAAAGTGGACACCAGGGTGCCAG
ATCCCCAAGAAGGCACTCGCCAGGTAATGAACATAGTCTCTTCCTGGCTGTGGAAGGAGCTGGGGAAACG
CAAGCGGCCACGCGTCTGCACCAAAGAAGAGTTTATCAACAAGGTGCGCAGCAATGCAGCACTGGGAGCA
ATATTTGAAGAGGAAAAAGAATGGAAGACGGCTGTGGAAGCTGTGAATGATCCAAGGTTTTGGGCCCTAG
TGGATAGGGAGAGAGAACACCACCTGAGAGGAGAGTGTCACAGCTGTGTGTACAACATGATGGGAAAAAG
AGAAAAGAAGCAAGGAGAGTTCGGGAAAGCAAAAGGTAGCCGCGCCATCTGGTACATGTGGTTGGGAGCC
AGATTCTTGGAGTTTGAAGCCCTTGGATTCTTGAACGAGGACCATTGGATGGGAAGAGAAAACTCAGGAG
GTGGAGTCGAAGGGTTAGGATTGCAAAGACTTGGATACATTCTAGAAGAAATGAATCGGGCACCAGGAGG
AAAGATGTACGCAGATGACACTGCTGGCTGGGACACCCGCATTAGTAAGTTTGATCTGGAGAATGAAGCT
CTGATTACCAACCAAATGGAGGAAGGGCACAGAACTCTGGCGTTGGCCGTGATTAAATACACATACCAAA
ACAAAGTGGTGAAGGTTCTCAGACCAGCTGAAGGAGGAAAAACAGTTATGGACATCATTTCAAGACAAGA
CCAGAGAGGGAGTGGACAAGTTGTCACTTATGCTCTCAACACATTCACCAACTTGGTGGTGCAGCTTATC
CGGAACATGGAAGCTGAGGAAGTGTTAGAGATGCAAGACTTATGGTTGTTGAGGAAGCCAGAGAAAGTGA
CCAGATGGTTGCAGAGCAATGGATGGGATAGACTCAAACGAATGGCGGTCAGTGGAGATGACTGCGTTGT
GAAGCCAATCGATGATAGGTTTGCACATGCCCTCAGGTTCTTGAATGACATGGGAAAAGTTAGGAAAGAC
ACACAGGAGTGGAAACCCTCGACTGGATGGAGCAATTGGGAAGAAGTCCCGTTCTGCTCCCACCACTTCA
ACAAGCTGTACCTCAAGGATGGGAGATCCATTGTGGTCCCTTGCCGCCACCAAGATGAACTGATTGGCCG
AGCTCGCGTCTCACCAGGGGCAGGATGGAGCATCCGGGAGACTGCCTGTCTTGCAAAATCATATGCGCAG
ATGTGGCAGCTCCTTTATTTCCACAGAAGAGACCTTCGACTGATGGCTAATGCCATTTGCTCGGCTGTGC
CAGTTGACTGGGTACCAACTGGGAGAACCACCTGGTCAATCCATGGAAAGGGAGAATGGATGACCACTGA
GGACATGCTCATGGTGTGGAATAGAGTGTGGATTGAGGAGAACGACCATATGGAGGACAAGACTCCTGTA
ACAAAATGGACAGACATTCCCTATCTAGGAAAAAGGGAGGACTTATGGTGTGGATCCCTTATAGGGCACA
GACCCCGCACCACTTGGGCTGAAAACATCAAAGACACAGTCAACATGGTGCGCAGGATCATAGGTGATGA
AGAAAAGTACATGGACTATCTATCCACCCAAGTCCGCTACTTGGGTGAGGAAGGGTCCACACCCGGAGTG
TTGTAAGCACCAATTTTAGTGTTGTCAGGCCTGCTAGTCAGCCACAGTTTGGGGAAAGCTGTGCAGCCTG
TAACCCCCCCAGGAGAAGCTGGGAAACCAAGCTCATAGTCAGGCCGAGAACGCCATGGCACGGAAGAAGC
CATGCTGCCTGTGAGCCCCTCAGAGGACACTGAGTCAAAAAACCCCACGCGCTTGGAAGCGCAGGATGGG
AAAAGAAGGTGGCGACCTTCCCCACCCTTCAATCTGGGGCCTGAACTGGAGACTAGCTGTGAATCTCCAG
CAGAGGGACTAGTGGTTAGAGGAGACCCCCCGGAAAACGCAAAACAGCATATTGACGTGGGAAAGACCAG
AGACTCCATGAGTTTCCACCACGCTGGCCGCCAGGCACAGATCGCCGAACTTCGGCGGCCGGTGTGGGGA
AATCCATGGTTTCT
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