Host Protein General Information

  Protein Name
MAP kinase kinase 1
  Gene Name
MAP2K1
  Host Species
Homo sapiens
  Uniprot Entry Name
MP2K1_HUMAN
  Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
  EC Number
2.7.12.2
  Subcellular Location
Cytoplasm; cytoskeleton; microtubule organizing center
  External Link
NCBI Gene ID
5604
Uniprot ID
Q02750
Ensembl ID
ENSG00000169032
HGNC ID
6840
  Related KEGG Pathway
Chemokine signaling pathway hsa04062            Pathway Map 
Neutrophil extracellular trap formation hsa04613            Pathway Map 
Toll-like receptor signaling pathway hsa04620            Pathway Map 
Natural killer cell mediated cytotoxicity hsa04650            Pathway Map 
T cell receptor signaling pathway hsa04660            Pathway Map 
B cell receptor signaling pathway hsa04662            Pathway Map 
Fc epsilon RI signaling pathway hsa04664            Pathway Map 
Fc gamma R-mediated phagocytosis hsa04666            Pathway Map 
Salmonella infection hsa05132            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Hepatitis C hsa05160            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Influenza A hsa05164            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Human T-cell leukemia virus 1 infection hsa05166            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
EGFR tyrosine kinase inhibitor resistance hsa01521            Pathway Map 
Endocrine resistance hsa01522            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Chemical carcinogenesis - receptor activation hsa05207            Pathway Map 
Chemical carcinogenesis - reactive oxygen species hsa05208            Pathway Map 
Central carbon metabolism in cancer hsa05230            Pathway Map 
Choline metabolism in cancer hsa05231            Pathway Map 
PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235            Pathway Map 
Colorectal cancer hsa05210            Pathway Map 
Renal cell carcinoma hsa05211            Pathway Map 
Pancreatic cancer hsa05212            Pathway Map 
Endometrial cancer hsa05213            Pathway Map 
Glioma hsa05214            Pathway Map 
Prostate cancer hsa05215            Pathway Map 
Thyroid cancer hsa05216            Pathway Map 
Melanoma hsa05218            Pathway Map 
Bladder cancer hsa05219            Pathway Map 
Chronic myeloid leukemia hsa05220            Pathway Map 
Acute myeloid leukemia hsa05221            Pathway Map 
Non-small cell lung cancer hsa05223            Pathway Map 
Breast cancer hsa05224            Pathway Map 
Hepatocellular carcinoma hsa05225            Pathway Map 
Gastric cancer hsa05226            Pathway Map 
Oocyte meiosis hsa04114            Pathway Map 
Apoptosis hsa04210            Pathway Map 
Cellular senescence hsa04218            Pathway Map 
Regulation of actin cytoskeleton hsa04810            Pathway Map 
Focal adhesion hsa04510            Pathway Map 
Gap junction hsa04540            Pathway Map 
Signaling pathways regulating pluripotency of stem cells hsa04550            Pathway Map 
Vascular smooth muscle contraction hsa04270            Pathway Map 
Osteoclast differentiation hsa04380            Pathway Map 
Cushing syndrome hsa04934            Pathway Map 
Insulin signaling pathway hsa04910            Pathway Map 
GnRH signaling pathway hsa04912            Pathway Map 
Progesterone-mediated oocyte maturation hsa04914            Pathway Map 
Estrogen signaling pathway hsa04915            Pathway Map 
Melanogenesis hsa04916            Pathway Map 
Prolactin signaling pathway hsa04917            Pathway Map 
Thyroid hormone signaling pathway hsa04919            Pathway Map 
Oxytocin signaling pathway hsa04921            Pathway Map 
Relaxin signaling pathway hsa04926            Pathway Map 
Parathyroid hormone synthesis, secretion and action hsa04928            Pathway Map 
GnRH secretion hsa04929            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
Long-term potentiation hsa04720            Pathway Map 
Neurotrophin signaling pathway hsa04722            Pathway Map 
Cholinergic synapse hsa04725            Pathway Map 
Serotonergic synapse hsa04726            Pathway Map 
Long-term depression hsa04730            Pathway Map 
Alzheimer disease hsa05010            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
MAPK signaling pathway hsa04010            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
Ras signaling pathway hsa04014            Pathway Map 
Rap1 signaling pathway hsa04015            Pathway Map 
cGMP-PKG signaling pathway hsa04022            Pathway Map 
cAMP signaling pathway hsa04024            Pathway Map 
HIF-1 signaling pathway hsa04066            Pathway Map 
FoxO signaling pathway hsa04068            Pathway Map 
Sphingolipid signaling pathway hsa04071            Pathway Map 
Phospholipase D signaling pathway hsa04072            Pathway Map 
mTOR signaling pathway hsa04150            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
VEGF signaling pathway hsa04370            Pathway Map 
Apelin signaling pathway hsa04371            Pathway Map 
TNF signaling pathway hsa04668            Pathway Map 
Alcoholism hsa05034            Pathway Map 
Autophagy - animal hsa04140            Pathway Map 
  3D Structure
PDB ID: 1S9J 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver . . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ALPELISIB . 56649450  D0W7HE  DGIdb
axitinib . 6450551  D01ZRI  DrugCentral
AZD-8330 . 16666708  D0P0HI  DGIdb
BINIMETINIB . 10288191  D0C4LF  DGIdb
binimetinib . 10288191  D0C4LF  DrugCentral
bosutinib . 5328940  D0OB0F  DrugCentral
CERITINIB . 57379345  D04LVK  DGIdb
CETUXIMAB . ?  D0N5OV  DGIdb
CHEMBL202721 . 9914412  D0QC0W  DGIdb
CHEMBL406845 . ?  D06CIJ  DGIdb
CI-1040 . 6918454  D0B9BU  DGIdb
COBIMETINIB . . . DGIdb
cobimetinib . . . DrugCentral
COBIMETINIB FUMARATE . 16222096  D0FJ9I  DGIdb
DABRAFENIB . 44462760  D05ROI  DGIdb
DASATINIB . 3062316  D0E6XR  DGIdb
dasatinib . 3062316  D0E6XR  DrugCentral
DOVITINIB . 135611162  D07OZR  DGIdb
ENCORAFENIB . 50922675  D0TK7R  DGIdb
fedratinib . 16722836  D0G8BM  DrugCentral
ILORASERTIB . 46207586  D08HOM  DGIdb
JNJ-7706621 . 5330790  D04NGS  DGIdb
MEKINIST . 11707110  D04XVN  DGIdb
neratinib . . . DrugCentral
nintedanib . 135423438  D09HNV  DrugCentral
OMIPALISIB . 25167777  D03EZE  DGIdb
PANITUMUMAB . ?  D0HU9H  DGIdb
PD-0166285 . 5311382  D0H8KG  DGIdb
PD-0325901 . 9826528  D0K0YC  DGIdb
PIMASERTIB . 44187362  D03CHM  DGIdb
PLX-4720 . 24180719  D0F5JZ  DGIdb
RG-7167 . . D0ZG1Y  DGIdb
RO-4987655 . 11548630  D09GHB  DGIdb
ruxolitinib . 25126798  D04LKS  DrugCentral
SELUMETINIB . 10127622  D0T5DP  DGIdb
selumetinib . 10127622  D0T5DP  DrugCentral
STAUROSPORINE . 44259  D0E3TC  DGIdb
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb
TAK-733 . 24963252  D0I3RD  DGIdb
TOZASERTIB . 5494449  D02XNW  DGIdb
TRAMETINIB . 11707110  D04XVN  DGIdb
trametinib . 11707110  D04XVN  DrugCentral
VANDETANIB . 3081361  D0G6QF  DGIdb
vandetanib . 3081361  D0G6QF  DrugCentral
VEMURAFENIB . 42611257  D0Y9EW  DGIdb

Protein Sequence Information

MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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