Host Protein General Information

  Protein Name
Activated CDC42 kinase 1
  Gene Name
TNK2
  Host Species
Homo sapiens
  Uniprot Entry Name
ACK1_HUMAN
  Protein Families
Protein kinase superfamily, Tyr protein kinase family
  EC Number
2.7.10.2; 2.7.11.1
  Subcellular Location
Cell membrane
  External Link
NCBI Gene ID
10188
Uniprot ID
Q07912
Ensembl ID
ENSG00000061938
HGNC ID
19297
  3D Structure
PDB ID: 1CF4 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver . . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ADAVOSERTIB . 24856436  D02KKA  DGIdb
ALISERTIB . 24771867  D0S4JK  DGIdb
axitinib . 6450551  D01ZRI  DrugCentral
BOSUTINIB . 5328940  D0OB0F  DGIdb
bosutinib . 5328940  D0OB0F  DrugCentral
bosutinib . 5328940  D0OB0F  .
CHEMBL202721 . 9914412  D0QC0W  DGIdb
CHEMBL406845 . ?  D06CIJ  DGIdb
crizotinib . 11626560  D03ZBT  DrugCentral
CYC-116 . 6420138  D0CY1B  DGIdb
DASATINIB . 3062316  D0E6XR  DGIdb
dasatinib . 3062316  D0E6XR  DrugCentral
ENTRECTINIB . 25141092  D0O0LS  DGIdb
entrectinib . 25141092  D0O0LS  DrugCentral
fedratinib . 16722836  D0G8BM  DrugCentral
GEFITINIB . 123631  D09XZB  DGIdb
gefitinib . 123631  D09XZB  DrugCentral
ILORASERTIB . 46207586  D08HOM  DGIdb
lorlatinib . 71731823  D0AF6O  DrugCentral
midostaurin . 9829523  D07NVU  DrugCentral
neratinib . . . DrugCentral
nintedanib . 135423438  D09HNV  DrugCentral
PAZOPANIB . . . DGIdb
PD-0166285 . 5311382  D0H8KG  DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
R-406 . 11213558  D0S6TK  DGIdb
ruxolitinib . 25126798  D04LKS  DrugCentral
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb

Protein Sequence Information

MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPADKIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLLGSWGPAHHKR
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