Host Protein General Information

  Protein Name
Gamma-secretase subunit APH-1B
  Gene Name
APH1B
  Host Species
Homo sapiens
  Uniprot Entry Name
APH1B_HUMAN
  Protein Families
APH-1 family
  Subcellular Location
Membrane
  External Link
NCBI Gene ID
83464
Uniprot ID
Q8WW43
Ensembl ID
ENSG00000106144
HGNC ID
24080
  Related KEGG Pathway
Notch signaling pathway hsa04330            Pathway Map 
Alzheimer disease hsa05010            Pathway Map 
  3D Structure
AlphaFold ID: Q8WW43 
  2D PNG Download  
  mmCIF File Download   
  PDB File Download   

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver . . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
AVAGACESTAT . 46883536  D02JOH  DGIdb
BEGACESTAT . 11269353  D09ZVC  DGIdb
GSI-136 . 11358855  D0U6FT  DGIdb
IC261 . 5288600  D0UN8H  DGIdb
MK-0752 . 9803433  D02HNG  DGIdb
SEMAGACESTAT . 9843750  D01LXD  DGIdb
TARENFLURBIL . 92337  D05FGR  DGIdb

Protein Sequence Information

MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKNFLLYNQRSR
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