Host Protein General Information

  Protein Name
Serine/threonine-protein kinase TBK1
  Gene Name
TBK1
  Host Species
Homo sapiens
  Uniprot Entry Name
TBK1_HUMAN
  Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily
  EC Number
2.7.11.1
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
29110
Uniprot ID
Q9UHD2
Ensembl ID
ENSG00000183735
HGNC ID
11584
  Related KEGG Pathway
Toll-like receptor signaling pathway hsa04620            Pathway Map 
NOD-like receptor signaling pathway hsa04621            Pathway Map 
RIG-I-like receptor signaling pathway hsa04622            Pathway Map 
Cytosolic DNA-sensing pathway hsa04623            Pathway Map 
IL-17 signaling pathway hsa04657            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Hepatitis C hsa05160            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Measles hsa05162            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Influenza A hsa05164            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Herpes simplex virus 1 infection hsa05168            Pathway Map 
Epstein-Barr virus infection hsa05169            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
Coronavirus disease - COVID-19 hsa05171            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Alcoholic liver disease hsa04936            Pathway Map 
Amyotrophic lateral sclerosis hsa05014            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
Ras signaling pathway hsa04014            Pathway Map 
Mitophagy - animal hsa04137            Pathway Map 
Autophagy - animal hsa04140            Pathway Map 
  3D Structure
PDB ID: 4EFO 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ADAVOSERTIB . 24856436  D02KKA  DGIdb
AMLEXANOX . 2161  D0G5UB  DGIdb
amlexanox . 2161  D0G5UB  DrugCentral
bosutinib . 5328940  D0OB0F  DrugCentral
crizotinib . 11626560  D03ZBT  DrugCentral
CYC-116 . 6420138  D0CY1B  DGIdb
ENTRECTINIB . 25141092  D0O0LS  DGIdb
erlotinib . 176870  D07POC  DrugCentral
fedratinib . 16722836  D0G8BM  DrugCentral
midostaurin . 9829523  D07NVU  DrugCentral
nintedanib . 135423438  D09HNV  DrugCentral
PF-00562271 . 11713159  D01SJT  DGIdb
R-406 . 11213558  D0S6TK  DGIdb
ruboxistaurin . 153999  D0W3LI  DrugCentral
ruxolitinib . 25126798  D04LKS  DrugCentral
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb

Protein Sequence Information

MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL
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