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| Strain Information | Strain Name |
Dengue virus 3 (strain D3/SG/05K863DK1/2005)
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| Strain Family |
Flaviviridae
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| RNA Binding Site |
3'UTR
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| Virus Information | Virus Name |
Dengue virus 3 (DENV3)
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| Taxonomy ID | 11069 | ||||||||
Full list of proteins interacting with the 3'UTR of this Strain
| Protein Name | Uniprot ID | Host Species | Pro Info | Detection Method | Infection Cell | Cell ID | Cell Originated Tissue | Infection Time | Interaction Score | Fold Change |
|---|---|---|---|---|---|---|---|---|---|---|
| Chromodomain-helicase-DNA-binding protein 1 | O14646 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Cytochrome b-c1 complex subunit 8 | O14949 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| E3 ubiquitin-protein ligase TRIM71 | Q2Q1W2 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Elongation factor 2 | P13639 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Enhancer of mRNA-decapping protein 3 | Q96F86 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| MAP activator with WD repeats | Q9Y3F4 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Probable ATP-dependent RNA helicase DDX6 | P26196 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Protein lin-28 homolog B | Q6ZN17 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Ras-related protein Rab-18 | Q9NP72 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| RecQ protein-like 2 | Q14191 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| RNA cytosine C(5)-methyltransferase NSUN2 | Q08J23 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| RNA-binding protein RO60 | P10155 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| SART-3 | Q15020 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Tropomyosin alpha-3 chain | P06753 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Vigilin | Q00341 | Homo sapiens | Pro Info | RNA chromatography and quantitative mass spectrometry | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
Functional Go Enrichment analysis of those proteins interacting with the 3'UTR of this Strain
| GO Term | GO Category | GO ID | Adjusted P-value | Odds Ratio | Combined Score |
|---|---|---|---|---|---|
| RNA Binding | Molecular Function |
GO:0003723
|
7.02E-06 | 19.88195435 | 313.3224021 |
| mRNA Binding | Molecular Function |
GO:0003729
|
0.025909446 | 17.65770609 | 120.0856346 |
| Cadherin Binding | Molecular Function |
GO:0045296
|
0.025909446 | 15.56091772 | 100.3112105 |
| Four-Way Junction Helicase Activity | Molecular Function |
GO:0009378
|
0.032088366 | 356.8035714 | 1993.609467 |
| U4 snRNA Binding | Molecular Function |
GO:0030621
|
0.032088366 | 356.8035714 | 1993.609467 |
| MutLalpha Complex Binding | Molecular Function |
GO:0032405
|
0.032088366 | 285.4285714 | 1542.867593 |
| tRNA Methyltransferase Activity | Molecular Function |
GO:0016427
|
0.032088366 | 237.8452381 | 1249.077685 |
| Bubble DNA Binding | Molecular Function |
GO:0000405
|
0.032088366 | 237.8452381 | 1249.077685 |
| Oxidized Purine DNA Binding | Molecular Function |
GO:0032357
|
0.032982128 | 178.3660714 | 892.01312 |
| G-quadruplex DNA Binding | Molecular Function |
GO:0051880
|
0.032982128 | 178.3660714 | 892.01312 |
| mRNA Methyltransferase Activity | Molecular Function |
GO:0008174
|
0.036582843 | 142.6785714 | 685.0073411 |
| U6 snRNA Binding | Molecular Function |
GO:0017070
|
0.036582843 | 118.8869048 | 551.0048325 |
| 3'-5' DNA Helicase Activity | Molecular Function |
GO:0043138
|
0.036582843 | 109.7362637 | 500.5003914 |
| Translation Elongation Factor Activity | Molecular Function |
GO:0003746
|
0.036582843 | 109.7362637 | 500.5003914 |
| Four-Way Junction DNA Binding | Molecular Function |
GO:0000400
|
0.03899444 | 95.0952381 | 421.091823 |
| Ubiquitin-Specific Protease Binding | Molecular Function |
GO:1990381
|
0.045632793 | 75.06015038 | 315.7300333 |
| GTPase Activity | Molecular Function |
GO:0003924
|
0.046048752 | 11.53670664 | 47.42778563 |
| Ribonucleoside Triphosphate Phosphatase Activity | Molecular Function |
GO:0017111
|
0.046048752 | 11.31859931 | 46.13161906 |
| Peptidase Activator Activity | Molecular Function |
GO:0016504
|
0.046048752 | 61.99378882 | 249.5520252 |
| miRNA Binding | Molecular Function |
GO:0035198
|
0.052767913 | 50.91071429 | 195.3922669 |
| P-body | Cellular Component |
GO:0000932
|
0.000937683 | 62.203125 | 647.291076 |
| Intracellular Non-Membrane-Bounded Organelle | Cellular Component |
GO:0043232
|
0.021220162 | 7.897058824 | 52.07039086 |
| Nuclear Lumen | Cellular Component |
GO:0031981
|
0.022948416 | 9.001405811 | 54.99752089 |
| Chromosome | Cellular Component |
GO:0005694
|
0.042475622 | 18.82526116 | 94.68137786 |
| Respiratory Chain Complex III | Cellular Component |
GO:0045275
|
0.042475622 | 142.6785714 | 685.0073411 |
| Mitochondrial Respiratory Chain Complex III | Cellular Component |
GO:0005750
|
0.042475622 | 142.6785714 | 685.0073411 |
| RISC Complex | Cellular Component |
GO:0016442
|
0.042997196 | 118.8869048 | 551.0048325 |
| Nucleolus | Cellular Component |
GO:0005730
|
0.066581462 | 6.255533854 | 25.00777538 |
| Endoplasmic Reticulum Tubular Network | Cellular Component |
GO:0071782
|
0.066581462 | 57.02857143 | 225.0399736 |
| Aggresome | Cellular Component |
GO:0016235
|
0.080412942 | 41.91386555 | 153.0686933 |
| Nucleus | Cellular Component |
GO:0005634
|
0.092780926 | 3.028320313 | 10.33749278 |
| Actin Filament | Cellular Component |
GO:0005884
|
0.132383286 | 20.32142857 | 60.09446475 |
| Cytoplasmic Stress Granule | Cellular Component |
GO:0010494
|
0.132383286 | 18.96190476 | 54.81664896 |
| Lipid Droplet | Cellular Component |
GO:0005811
|
0.132383286 | 17.55202822 | 49.44377842 |
| Intracellular Membrane-Bounded Organelle | Cellular Component |
GO:0043231
|
0.133594653 | 2.508683243 | 6.790504464 |
| Nuclear Chromosome | Cellular Component |
GO:0000228
|
0.133594653 | 15.11474164 | 40.42201147 |
| Cytoplasmic Vesicle Lumen | Cellular Component |
GO:0060205
|
0.151154224 | 12.45050125 | 31.0045927 |
| Ficolin-1-Rich Granule Lumen | Cellular Component |
GO:1904813
|
0.152264892 | 11.6293911 | 28.20998397 |
| Ficolin-1-Rich Granule | Cellular Component |
GO:0101002
|
0.211288855 | 7.729117877 | 15.7989146 |
| Polymeric Cytoskeletal Fiber | Cellular Component |
GO:0099513
|
0.280567065 | 5.335768398 | 9.108697425 |
| P-body Assembly | Biological Process |
GO:0033962
|
0.002960036 | 341.4700855 | 3570.560667 |
| miRNA-mediated Gene Silencing By Inhibition Of Translation | Biological Process |
GO:0035278
|
0.002960036 | 256.0641026 | 2548.915005 |
| miRNA Metabolic Process | Biological Process |
GO:0010586
|
0.002960036 | 236.3550296 | 2319.006332 |
| miRNA-mediated Gene Silencing | Biological Process |
GO:0035195
|
0.006838902 | 127.9551282 | 1111.473264 |
| miRNA Processing | Biological Process |
GO:0035196
|
0.008328123 | 102.3333333 | 845.9155332 |
| Spliceosomal snRNP Assembly | Biological Process |
GO:0000387
|
0.009298623 | 87.69230769 | 699.2344145 |
| Regulation Of Translation | Biological Process |
GO:0006417
|
0.009772941 | 24.85678392 | 193.1328378 |
| Nucleosome Organization | Biological Process |
GO:0034728
|
0.028584177 | 41.96417281 | 275.4132478 |
| Negative Regulation Of Amide Metabolic Process | Biological Process |
GO:0034249
|
0.034286821 | 33.63313609 | 206.4405576 |
| Negative Regulation Of Macromolecule Biosynthetic Process | Biological Process |
GO:0010558
|
0.034286821 | 31.87339744 | 192.3522519 |
| Negative Regulation Of Translation | Biological Process |
GO:0017148
|
0.034286821 | 29.12820513 | 170.7550129 |
| Regulation Of pre-miRNA Processing | Biological Process |
GO:2000631
|
0.034286821 | 356.8035714 | 1993.609467 |
| Regulation Of mRNA Export From Nucleus | Biological Process |
GO:0010793
|
0.034286821 | 356.8035714 | 1993.609467 |
| Regulation Of Ribonucleoprotein Complex Localization | Biological Process |
GO:2000197
|
0.034286821 | 356.8035714 | 1993.609467 |
| Regulation Of Post-Transcriptional Gene Silencing By RNA | Biological Process |
GO:1900368
|
0.034286821 | 356.8035714 | 1993.609467 |
| Non-Membrane-Bounded Organelle Assembly | Biological Process |
GO:0140694
|
0.034286821 | 22.96356275 | 124.1743431 |
| G-quadruplex DNA Unwinding | Biological Process |
GO:0044806
|
0.034286821 | 285.4285714 | 1542.867593 |
| Negative Regulation Of miRNA Processing | Biological Process |
GO:1903799
|
0.034286821 | 285.4285714 | 1542.867593 |
| Nuclear-Transcribed mRNA Catabolic Process, Deadenylation-Independent Decay | Biological Process |
GO:0031086
|
0.034286821 | 285.4285714 | 1542.867593 |
| Negative Regulation Of Cellular Biosynthetic Process | Biological Process |
GO:0031327
|
0.034286821 | 22.62108262 | 121.6741585 |
Functional KEGG Enrichment analysis of those proteins interacting with the 3'UTR of this Strain
| Pathways | Category | Adjusted P-value | Odds Ratio | Combined Score |
|---|---|---|---|---|
| RNA degradation | KEGG Pathway | 0.020823936 | 39.77622378 | 256.9617376 |
| Cardiac muscle contraction | KEGG Pathway | 0.020823936 | 36.01809955 | 225.8171841 |
| Thyroid cancer | KEGG Pathway | 0.20095381 | 39.58134921 | 142.3784815 |
| Hypertrophic cardiomyopathy | KEGG Pathway | 0.220373127 | 15.96789727 | 43.53924819 |
| Dilated cardiomyopathy | KEGG Pathway | 0.220373127 | 14.95488722 | 39.84310238 |
| AMPK signaling pathway | KEGG Pathway | 0.220373127 | 11.92436975 | 29.20757581 |
| Oxidative phosphorylation | KEGG Pathway | 0.220373127 | 10.74296537 | 25.2572222 |
| Systemic lupus erythematosus | KEGG Pathway | 0.220373127 | 10.5815565 | 24.72713132 |
| Adrenergic signaling in cardiomyocytes | KEGG Pathway | 0.220373127 | 9.509108341 | 21.26847243 |
| Oxytocin signaling pathway | KEGG Pathway | 0.220373127 | 9.258636788 | 20.47739449 |
| Non-alcoholic fatty liver disease | KEGG Pathway | 0.220373127 | 9.198051948 | 20.28704233 |
| RNA transport | KEGG Pathway | 0.239831219 | 7.644787645 | 15.54915912 |
| Diabetic cardiomyopathy | KEGG Pathway | 0.240206322 | 6.995403112 | 13.65747629 |
| Thermogenesis | KEGG Pathway | 0.25135051 | 6.108225108 | 11.17062738 |
| Parkinson disease | KEGG Pathway | 0.25135051 | 5.684619816 | 10.02709585 |
| Prion disease | KEGG Pathway | 0.255391807 | 5.176733193 | 8.697408913 |
| Huntington disease | KEGG Pathway | 0.255391807 | 4.608899297 | 7.269389894 |
| MicroRNAs in cancer | KEGG Pathway | 0.255391807 | 4.548312529 | 7.12096141 |
| Amyotrophic lateral sclerosis | KEGG Pathway | 0.268166357 | 3.861078316 | 5.495879306 |
| Alzheimer disease | KEGG Pathway | 0.268166357 | 3.807647516 | 5.3743343 |
Virus RNA Sequence Information
|
>MK506265.1 Dengue virus type 3 isolate h87-2007, complete genome
TACGTGGACCGACAAGAACAGTTTCGACTCGGAAGCTTGCTTAACGTAGTGCTGACAGTTTTTTATTAGA
GAGCAGATCTCTGATGAACAACCAACGGAAAAAGACGGGAAAACCGTCTATCAATATGCTGAAACGCGTG
AGAAACCGTGTGTCAACTGGATCACAGTTGGCGAAGAGATTCTCAAGAGGATTGCTGAACGGCCAAGGAC
CAATGAAATTGGTTATGGCGTTTATAGCTTTCCTCAGATTTCTAGCCATTCCACCGACAGCAGGAGTCTT
GGCTAGATGGGGTACCTTTAAGAAGTCGGGGGCTATTAAGGTCTTAAAAGGCTTCAAGAAGGAGATCTCA
AACATGCTGAGCATTATCAACAAACGGAAAAAGACATCGCTCTGTCTCATGATGATGTTACCAGCAACAC
TTGCTTTCCACTTAACTTCACGAGATGGAGAGCCGCGCATGATTGTGGGGAAGAATGAAAGAGGAAAATC
CCTACTTTTTAAGACAGCCTCTGGAATCAACATGTGCACACTCATAGCCATGGATTTGGGAGAGATGTGT
GATGACACGGTCACTTACAAATGCCCCCACATTACCGAAGTGGAGCCTGAAGACATTGACTGCTGGTGCA
ACCTTACATCGACATGGGTGACTTATGGAACATGCAATCAAGCTGGAGAGCATAGACGCGATAAGAGATC
AGTGGCGTTAGCTCCCCATGTCGGCATGGGACTGGACACACGCACTCAAACCTGGATGTCGGCTGAAGGA
GCTTGGAGACAAGTCGAGAAGGTAGAGACATGGGCCCTTAGGCACCCAGGGTTTACCATACTAGCCCTAT
TTCTTGCCCATTACATAGGCACTTCCTTGACCCAGAAAGTGGTTATTTTTATACTATTAATGCTGGTTAC
CCCATCCATGACAATGAGATGTGTGGGAGTAGGAAACAGAGATTTTGTGGAAGGCCTATCGGGAGCCACG
TGGGTTGACGTGGTGCTCGAGCACGGTGGGTGTGTGACTACCATGGCTAAGAACAAGCCCACGCTGGACA
TAGAGCTTCAGAAGACCGAGGCCACCCAACTGGCGACCCTAAGGAAGCTATGCATTGAGGGAAAAATTAC
CAACATAACAACCGACTCAAGATGTCCCACCCAAGGGGAAGCGATTTTACCTGAGGAGCAGGACCAGAAC
TACGTGTGTAAGCATACATACGTGGACAGAGGCTGGGGAAACGGTTGTGGTTTGTTTGGCAAGGGAAGCT
TGGTGACATGCGCGAAATTTCAATGTTTAGAATCAATAGAGGGAAAAGTGGTGCAACATGAGAACCTCAA
ATACACCGTCATCATCACAGTGCACACAGGAGACCAACACCAGGTGGGAAATGAAACGCAGGGAGTTACG
GCTGAGATAACATCCCAGGCATCAACCGCTGAAGCCATTTTACCTGGATATGGAACCCTCGGGCTAGAAT
GCTCACCACGGACAGGTTTGGATTTCAATGAAATGATTTTATTGACAATGAAGAACAAAGCATGGATGGT
ACATAGACAATGGTTCTTTGACTTACCCCTACCATGGACATCAGGAGCTACAACAGAAACACCAACTTGG
AACAGGAGAGAGCTTCTTGTGACATTTAAAAATGCACATGCAAAAAAGCAAGAAGTAGTTGTCCTTGGAT
CACAAGAGGGAGCAATGCATACAGCACTGACAGGAGCTACAGAGATCCAAACCTCAGGAGGCACAAGTAT
TTTTGCGGGGCACTTAAAATGTAGACTCAAGATGGACAAATTGGAACTCAAGGGGATGAGCTATGCAATG
TGCTTGAATACCTTTGTGTTGAAGAAAGAAGTCTCCGAAACGCAGCATGGGACAATACTCATTAAGGTTG
AGTACAAAGGGGAAGATGCACCCTGCAAGATTCCTTTCTCCACGGAGGATGGACAAGGGAAAGCTCACAA
TGGCAGACTGATCACAGCCAATCCAGTGGTGACCAAGAAGGAGGAGCCTGTCAACATTGAGGCTGAACCT
CCTTTTGGGGAAAGTAATATAGTAATTGGAATTGGAGACAAAGCCCTGAAAATCAACTGGTACAGGAAGG
GAAGCTCGATTGGGAAGATGTTCGAGGCCACTGCCAGAGGTGCAAGGCGCATGGCCATCTTGGGAGACAC
AGCCTGGGACTTTGGATCAGTGGGTGGTGTTTTGAATTCATTAGGGAAAATGGTCCACCAAATATTTGGG
AGTGCTTACACAGCCCTATTTAGTGGAGTCTCCTGGATAATGAAAATTGGAATAGGTGTCCTCTTAACCT
GGATAGGGTTGAATTCAAAAAACACTTCTATGTCATTTTCATGCATTGCGATAGGAATCATTACACTCTA
TCTGGGAGTCGTGGTGCAAGCTGACATGGGGTGTGTCATAAACTGGAAAGGCAAAGAACTCAAATGTGGA
AGTGGAATTTTCGTCACTAATGAGGTCCACACCTGGACAGAGCAATACAAATTTCAAGCAGACTCCCCCA
AAAGACTGGCAACAGCCATTGCAGGCGCTTGGGAGAATGGAGTGTGCGGAATTAGGTCAACAACCAGAAT
GGAGAACCTCTTGTGGAAGCAAATAGCCAATGAACTGAACTACATATTATGGGAAAACAACATCAAATTA
ACGGTAGTTGTAGGCGACATAACTGGGGTCTTAGAGCAAGGGAAAAGAACACTAACACCACAACCCATGG
AGCTAAAATATTCTTGGAAAACATGGGGAAAGGCAAAAATAGTGACAGCTGAAACACAAAATTCCTCTTT
CATAATAGATGGGCCAAGCACACCGGAGTGTCCAAGTGCCTCAAGAGCATGGAATGTGTGGGAGGTGGAA
GATTACGGGTTCGGAGTTTTCACAACCAACATATGGCTGAAACTCCGAGAGGTGTACACCCAACTATGTG
ACCATAGGCTAATGTCGGCAGCCGTCAAGGATGAGAGGGCCGTACACGCCGACATGGGCTATTGGATAGA
AAGCCAAAAGAATGGAAGTTGGAAGCTAGAAAAAGCATCCCTCATAGAGGTGAAAACCTGCACATGGCCA
AAATCACACACTCTTTGGAGCAATGATGTGCTAGAGAGTGACATGATTATCCCAAAGAGTCTAGCTGGTC
CCATTTCGCAACACAACCACAGGCCCGGGTACCACACCCAAACGGCAGGACCCTGGCACTTAGGAAAATT
GGAGCTGGACTTCAACTATTGTGAAGGAACAACAGTTGTCATCTCAGAAAACTGTGGGACAAGAGGCCCA
TCATTGAGAACAACAACAGTGTCAGGGAAGTTGATACACGAATGGTGTTGCCGCTCGTGCACACTTCCTC
CCCTGCGATACATGGGAGAAGACGGCTGCTGGTATGGCATGGAAATCAGACCCATTAATGAGAAAGAAGA
GAACATGGTAAAGTCTCTAGCCTCAGCAGGGAGTGGAAAGGTGGACAACTTCACAATGGGTGTCTTGTGT
TTGGCAATCCTCTTTGAAGAGGTGATGAGAGGAAAATTTGGGAAAAAACACATGATTGCAGGGGTTCTCT
TCACGTTTGTGCTCCTCCTCTCAGGGCAAATAACATGGAGAGACATGGCGCACACACTCATAATGATTGG
GTCCAACGCCTCTGACAGAATGGGGATGGGCGTCACTTACCTAGCTCTAATTGCAACATTTAAAATTCAG
CCATTCTTGGCTTTGGGATTCTTCCTGAGGAAACTGACATCTAGAGAAAATTTATTGCTGGGAGTTGGGT
TGGCCATGGCAGCAACGTTACGACTGCCAGAGGACATTGAACAAATGGCGAATGGAATTGCTTTGGGGCT
CATGGCTCTTAAACTGATAACACAATTTGAAACATACCAACTATGGACGGCATTAGTTTCCCTAACGTGT
TCAAATACAATTTTCACGTTGACTGTTGCCTGGAGAACAGCCACTCTGATTTTAGCCGGAATTTCGCTTT
TGCCAGTGTGCCAGTCTTCGAGCATGAGGAAAACAGATTGGCTCCCAATGACTGTGGCAGCTATGGGAGT
TCCACCCCTACCACTTTTTATTTTCAGTCTGAAAGATACACTCAAAAGGAGAAGCTGGCCACTGAATGAG
GGGGTGATGGCAGTTGGACTTGTGAGCATTCTGGCTAGTTCTCTCCTTAGGAATGATGTGCCCATGGCTG
GACCATTAGTGGCTGGGGGCTTGCTGATAGCGTGCTACGTCATAACTGGCACGTCAGCAGACCTCACTGT
AGAAAAAGCAGCAGATGTAACATGGGAGGAAGAGGCCGAGCAAACAGGAGTGTCCCACAATTTAATGATC
ACAGTTGATGATGATGGAACAATGAGAATAAAAGATGACGAGACTGAGAACATCTTAACAGTGCTTTTAA
AAACAGCACTACTAATAGTATCAGGCATCTTTCCATACTCCATACCCGCAACACTGTTGGTCTGGCATAC
TTGGCAAAAGCAAACCCAAAGATCCGGCGTCCTATGGGACGTACCCAGCCCCCCAGAGACACAGAAAGCG
GAACTGGAAGAAGGGGTCTATAGGATCAAACAGCAAGGAATTTTTGGGAAAACCCAAGTGGGGGTTGGAG
TACAGAAAGAAGGAGTTTTCCACACCATGTGGCACGTCACAAGAGGGGCAGTGTTGACACACAATGGGAA
AAGACTGGAACCAAACTGGGCTAGCGTGAAAAAAGATCTGATTTCATACGGAGGAGGATGGAGATTGAGT
GCACAATGGCAAAAGGGGGAGGAGGTGCAGGTTATTGCCGTAGAGCCTGGGAAGAACCCAAAGAACTTTC
AAACCATGCCAGGCATTTTTCAGACAACAACAGGGGAAATAGGAGCAATTGCACTGGATTTCAAGCCTGG
AACTTCAGGATCTCCCATCATAAACAGAGAGGGAAAGGTAGTGGGACTGTATGGCAATGGAGTGGTTACA
AAGAATGGAGGCTATGTCAGTGGAATAGCGCAAACAAATGCAGAACCAGATGGACCGACACCAGAGTTGG
AAGAAGAGATGTTCAAAAAGCGAAATCTAACCATAATGGATCTTCATCCTGGGTCAGGAAAGACGCGGAA
ATATCTTCCAGCTATTGTTAGAGAGGCAATCAAGAGACGCTTAAGGACTCTAATTTTGGCACCAACAAGG
GTAGTTGCAGCTGAGATGGAAGAAGCATTGAAAGGGCTCCCAATAAGGTATCAAACAACTGCAACAAAAT
CTGAACACACAGGAAGAGAGATTGTTGATCTAATGTGTCACGCAACGTTCACAATGCGCTTGCTGTCACC
AGTCAGGGTTCCAAACTACAACTTGATAATAATGGATGAGGCTCATTTCACAGACCCAGCCAGTATAGCG
GCTAGAGGGTACATATCAACTCGTGTAGGAATGGGAGAGGCAGCCGCAATTTTCATGACAGCAACACCCC
CTGGAACAGCTGATGCCTTTCCTCAGAGCAACGCTCCAATTCAAGATGAAGAGAGAGACATACCGGAACG
CTCATGGAATTCAGGCAATGAATGGATTACTGACTTTGTTGGGAAGACAGTGTGGTTTGTCCCTAGCATC
AAAGCCGGAAATGACATAGCAAACTGCTTGCGGAAAAATGGAAAAAAGGTCATTCAACTCAGCAGGAAGA
CCTTTGACACAGAATATCAAAAGACCAAACTGAATGATTGGGACTTTGTGGTGACAACAGACATTTCAGA
AATGGGAGCCAATTTCAAAGCAGATAGAGTGATCGACCCAAGAAGATGTCTCAAGCCGGTGATTTTGACA
AATGGACCCGAGCGGGTGATCCTGGCTGGACCAATGCCAGTCACCGTAGCGAGCGCTGCGCAAAGGAGAG
GGAGAGTTGGCAGGAACCCACAAAAAGAAAATGACCAGTACATATTCATGGGCCAGCCTCTCAACAATGA
TGAAGACCATGCTCACTGGACAGAAGCAAAAATGCTGCTGGACAACATCAACACACCAGAAGGGATTATA
CCAGCTCTCTTTGAACCAGAAAGGGAGAAGTCAGCCGCCATAGACGGCGAATACCGCCTGAAGGGTGAGT
CCAGGAAGACTTTCGTGGAACTCATGAGGAGGGGTGACCTCCCAGTTTGGCTAGCCCATAAAGTAGCATC
AGAAGGGATCAAATATACAGATAGAAAATGGTGCTTTGATGGAGAACGTAATAATCAAATTTTAGAGGAG
AATATGGATGTGGAAATCTGGACAAAGGAAGGAGAAAAGAAAAAACTGAGACCTAGGTGGCTTGATGCCC
GCACTTATTCAGATCCTTTAGCACTCAAGGAATTCAAGGATTTTGCAGCTGGCAGAAAGTCAATCGCCCT
TGATCTTGTGACAGAAATAGGAAGAGTGCCTTCACACTTAGCCCACAGAACGAGAAACGCCCTGGACAAT
TTGGTGATGCTGCACACGTCAGAACATGGCGGTAGGGCCTACAGGCATGCAGTGGAGGAACTACCAGAAA
CGATGGAAACACTCTTACTCCTGGGACTGATGATCTTGTTAACAGGTGGAGCAATGCTCTTCTTGATATC
AGGTAAAGGGATTGGAAAGACTTCAATAGGACTCATTTGTGTAATTGCTTCCAGCGGCATGTTATGGATG
GCTGATGTCCCACTCCAATGGATCGCGTCGGCTATAGTCCTGGAGTTTTTTATGATGGTGTTGCTCATAC
CAGAACCAGAAAAGCAGAGAACTCCCCAAGACAACCAACTCGCATATGTCGTGATAGGCATACTTACATT
GGCTGCAATAGTAGCGGCCAATGAAATGGGACTGTTGGAAACTACAAAGAGAGATTTAGGAATGTCTAAA
GAACCAGGTGTTGTTTCTTCAACCAGCTATTTGGACGTGGACTTGCACCCAGCATCAGCCTGGACATTGT
ACGCCGTGGCCACAACAGTAATAACACCAATGTTGAGACACACCATAGAGAATTCCACAGCAAATGTGTC
CCTGGCAGCCATAGCTAACCAGGCAGTGGTCCTGATGGGTTTAGACAAAGGATGGCCGATATCGAAAATG
GACTTGGGCGTACCACTATTGGCACTGGGTTGCTATTCACAAGTGAACCCACTAACTCTTGCAGCGGCAG
TACTTTTGCTAGTCACACATTATGCAATTATAGGTCCAGGATTGCAGGCAAAAGCCACTCGTGAAGCTCA
GAAAAGGACAGCTGCTGGAATAATGAAGAATCCAACGGTGGATGGAATAATGACAATAGACCTAGATCCT
GTAATATATGATTCAAAATTTGAAAAGCAACTAGGACAGGTTATGCTCCTGGTTCTGTGTGCAGTTCAAC
TTTTGTTAATGAGAACATCATGGGCCTTGTGTGAAGTTCTAACCCTAGCCACAGGACCAATAACAACACT
CTGGGAAGGATCACCTGGGAAGTTCTGGAACACCACGATAGCTGTTTCCATGGCGAACATCTTTAGAGGG
AGCTATTTAGCAGGAGCTGGGCTTGCTTTTTCTATCATGAAATCAGTTGGAACAGGAAAGAGAGGAACAG
GGTCACAAGGTGAAACCTTAGGAGAAAAGTGGAAAAAGAAATTAAATCAGTTATCCCGGAAAGAGTTTGA
CCTTTACAAGAAATCCGGAATCACCGAAGTGGATAGAACAGAAGCCAAAGAAGGGTTAAAAAGAGGAGAA
ATAACACACCATGCCGTGTCCAGAGGCAGCGCAAAACTTCAATGGTTCGTGGAGAGAAACATGGTCATTC
CTGAAGGAAGAGTCATAGACTTAGGCTGTGGAAGAGGAGGCTGGTCATATTACTGTGCAGGACTGAAAAA
AGTTACAGAAGTGCGAGGATACACAAAAGGCGGCCCAGGACACGAAGAACCAGTACCTATGTCTACATAC
GGATGGAACATAGTCAAGTTAATGAGTGGAAAGGATGTTTTTTATCTGCCACCTGAAAAGTGTGATACCC
TATTGTGTGACATTGGAGAATCTTCACCAAGCCCAACAGTGGAAGAAAGCAGAACCATAAGAGTCTTGAA
GATGGTTGAACCATGGCTAAAAAACAACCAGTTTTGCATTAAAGTATTGAACCCATACATGCCAACTGTG
ATTGAGCACTTAGAAAGACTACAAAGGAAACATGGAGGAATGCTTGTGAGAAATCCACTCTCACGAAACT
CCACGCACGAAATGTATTGGATATCCAATGGTACAGGCAACATCGTCTCTTCAGTCAACATGGTATCCAG
ATTGCTACTGAACAGATTCACAATGACACACAGGAGACCCACCATAGAGAAAGATGTGGATTTAGGAGCA
GGAACCCGACATGTCAATGCGGAACCAGAAACACCCAACATGGATGTCATTGGGGAAAGAATAAAAAGGA
TCAAAGAGGAGCATAGTTCAACATGGCACTATGATGATGAAAATCCTTACAAAACGTGGGCTTACCATGG
ATCCTATGAAGTAAAAGCCACAGGCTCAGCCTCCTCCATGATAAATGGAGTCGTGAAACTCCTCACAAAA
CCATGGGATGTGGTGCCCATGGTGACACAGATGGCAATGACAGATACAACTCCATTTGGCCAGCAAAGAG
TTTTTAAAGAGAAAGTGGACACCAGGACACCTAGGCCCATGCCAGGAACAAGAAAGGTTATGGAGATCAC
AGCGGAGTGGCTTTGGAGGACCCTGGGAAGGAACAAAAGACCCAGATTATGCACAAGGGAGGAGTTCACA
AAGAAGGTCAGAACCAACGCAGCTATGGGCGCTGTCTTCACAGAAGAGAACCAATGGGACAGTGCGAGAG
CTGCTGTTGAGGACGAAGAATTTTGGAAACTTGTGGACAGAGAACGTGAACTCCACAAACTGGGCAAGTG
TGGAAGCTGCGTTTACAACATGATGGGCAAGAGAGAGAAAAAACTTGGAGAGTTTGGTAAAGCAAAAGGC
AGTAGGGCTATATGGTACATGTGGTTGGGAGCCAGGTACCTTGAGTTCGAGGCGCTCGGATTCCTCAATG
AAGACCACTGGTTCTCGCGTGAAAACTCTTACAGTGGAGTAGAAGGAGAAGGACTGCACAAGCTGGGATA
CATCTTGAGAGATATTTCCAAGATACCCGGAGGAGCCATGTATGCTGATGACACAGCCGGTTGGGACACA
AGAATAACAGAAGATGACCTGCACAATGAGGAAAAAATCACACAGCAGATGGACCCTGAACACAGGCAGC
TAGCGAACGCTATATTCAAGCTCACATACCAAAACAAAGTGGTCAAAGTCCAACGACCAACTCCAAAGGG
CACGGTAATGGACATCATATCTAGGAAAGACCAAAGAGGCAGTGGACAGGTGGGAACTTATGGTCTGAAC
ACATTCACCAACATGGAAGCCCAGCTAATCAGACAAATGGAAGGAGAAGGCGTGTTGTCAAAGGCAGACC
TCGAGAACCCCCATCCGCTAGAGAAGAAAATTACACAATGGTTGGAAACTAAAGGAGTGGAGAGGTTAAA
AAGAATGGCCATCAGCGGGGATGATTGCGTAGTGAAACCAATCGACGACAGATTCGCCAATGCCCTGCTT
GCCCTGAACGATATGGGAAAGGTTAGGAAGGACATACCTCAATGGCAGCCATCAAAGGGATGGCATGATT
GGCAACAGGTCCCTTTCTGCTCCCACCACTTTCATGAATTGATCATGAAAGATGGAAGAAAGTTGGTAGT
TCCCTGCAGACCCCAGGACGAACTAATAGGAAGAGCGAGAATCTCTCAAGGAGCAGGATGGAGCCTTAGA
GAAACTGCATGTCTAGGGAAAGCCTACGCTCAAATGTGGACTCTCATGTATTTTCACAGAAGAGATCTTA
GACTAGCATCCAACGCCATATGTTCAGCAGTACCAGTCCATTGGGTCCCCACGAGCAGAACGACATGGTC
TATTCATGCTCACCATCAGTGGATGACTACAGAAGACATGCTTACTGTCTGGAACAGGGTGTGGATAGAG
GACAATCCATGGATGGAAGACAAAACTCCAGTCACAACGTGGGAAGATGTTCCATATCTAGGGAAGAGAG
AAGACCAATGGTGCGGATCATTCATAGGTCTCACTTCCAGAGCAACCTGGGCCCAGAACATACTCACAGC
AATCCAACAGGTGAGAAGCCTCATAGGCAATGAAGAGTTTCTGGACTACATGCCTTCGATGAAGAGATTC
AGGAAGGAGGAGGAGTCAGAGGGAGCCATTTGGTAAAAGCAGGAGGCAAACTGTCAGGCCACCTTAAGCC
ACAGTACGGAAGAAGCTGTGCAGCCTGTGAGCCCCGTCCAAGGACGTTAAAAGAAGAAGTCAGGCCCAAA
AGCCACGGTTTGAGCAAACCGTGCTGCCTGTAGCTCCGTCGTGGGGACGTAAAGCCTGGGAGGCTGCAAA
CCGTGGAAGCTGTACGCACGGTGTAGCAGACTAGTGGTTAGAGGAGACCCCTCCCATGACACAACGCAGC
AGCGGGGCCCGAGCACTGAGGGAAGCTGTACCTCCTTGCAAAGGACTAGAGGTTATAGGAGACCCCCCGC
AAACAAAAACAGCATATTGACGCTGGGAGAGACCAGAGATCCTGCTGTCTCCTCAGCATCATTCCAGGCA
CAGAACGCCA
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