Host Protein General Information

  Protein Name
Rho-associated protein kinase 2
  Gene Name
ROCK2
  Host Species
Homo sapiens
  Uniprot Entry Name
ROCK2_HUMAN
  Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family
  EC Number
2.7.11.1
  Subcellular Location
Cytoplasm; Cell membrane
  External Link
NCBI Gene ID
9475
Uniprot ID
O75116
Ensembl ID
ENSG00000134318
HGNC ID
10252
  Related KEGG Pathway
Chemokine signaling pathway hsa04062            Pathway Map 
Platelet activation hsa04611            Pathway Map 
Leukocyte transendothelial migration hsa04670            Pathway Map 
Pathogenic Escherichia coli infection hsa05130            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Salmonella infection hsa05132            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Regulation of actin cytoskeleton hsa04810            Pathway Map 
Focal adhesion hsa04510            Pathway Map 
Adherens junction hsa04520            Pathway Map 
Tight junction hsa04530            Pathway Map 
Vascular smooth muscle contraction hsa04270            Pathway Map 
Axon guidance hsa04360            Pathway Map 
Oxytocin signaling pathway hsa04921            Pathway Map 
cGMP-PKG signaling pathway hsa04022            Pathway Map 
cAMP signaling pathway hsa04024            Pathway Map 
Sphingolipid signaling pathway hsa04071            Pathway Map 
Wnt signaling pathway hsa04310            Pathway Map 
  3D Structure
PDB ID: 4L6Q 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) A549 Cells (Adenocarcinoma human alveolar basal epithelial cell) . Lung . P-value = 1.48130406105301e-05 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 1.48130406105301e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ALSTERPAULLONE . 5005498  D0H3EV  DGIdb
AST-487 . 11409972  D0N7AJ  DGIdb
bosutinib . 5328940  D0OB0F  DrugCentral
ceritinib . 57379345  D04LVK  DrugCentral
CHEMBL202721 . 9914412  D0QC0W  DGIdb
CHEMBL225519 . 11715767  D03DZO  DGIdb
crizotinib . 11626560  D03ZBT  DrugCentral
CYC-116 . 6420138  D0CY1B  DGIdb
delgocitinib . 50914062  D05UGH  DrugCentral
DOVITINIB . 135611162  D07OZR  DGIdb
FASUDIL . 3547  D03KKR  DGIdb
fasudil . 3547  D03KKR  DrugCentral
fedratinib . 16722836  D0G8BM  DrugCentral
GO-6976 . 3501  D08JPU  DGIdb
ILORASERTIB . 46207586  D08HOM  DGIdb
JNJ-7706621 . 5330790  D04NGS  DGIdb
KENPAULLONE . 3820  D00PWQ  DGIdb
LAUROGUADINE . . . DGIdb
LINIFANIB . 11485656  D0M9QZ  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
NETARSUDIL . 66599893  D04WYX  DGIdb
netarsudil . 66599893  D04WYX  DrugCentral
PALBOCICLIB . 5330286  D00UZR  DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
PH-797804 . 22049997  D0K2ZF  DGIdb
PROGESTERONE . 5994  D07BSQ  DGIdb
ripasudil . . . DrugCentral
ruxolitinib . 25126798  D04LKS  DrugCentral
SAR-407899 . 15604510  D00UET  DGIdb
SNS-314 . 24995524  D0OA5G  DGIdb
SP-600125 . 8515  D02PVB  DGIdb
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb
THROMBIN . . D0KT3X  DGIdb
tofacitinib . 9926791  D0EG1I  DrugCentral
VANDETANIB . 3081361  D0G6QF  DGIdb
vandetanib . 3081361  D0G6QF  DrugCentral
Y-27632 . 448042  D0B5LF  DGIdb
Y-39983 . 9810884  D0U9LT  DGIdb

Protein Sequence Information

MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS
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