Host Protein General Information

  Protein Name
Purine nucleoside phosphorylase
  Gene Name
PNP
  Host Species
Homo sapiens
  Uniprot Entry Name
PNPH_HUMAN
  Protein Families
PNP/MTAP phosphorylase family
  EC Number
2.4.2.1
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
4860
Uniprot ID
P00491
Ensembl ID
ENSG00000198805
HGNC ID
7892
  Related KEGG Pathway
Metabolic pathways hsa01100            Pathway Map 
Nucleotide metabolism hsa01232            Pathway Map 
Nicotinate and nicotinamide metabolism hsa00760            Pathway Map 
Purine metabolism hsa00230            Pathway Map 
  3D Structure
PDB ID: 1M73 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 0.593546156 FZR = 1
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 1.964323999 FZR = 1

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
acyclovir . 135398513  D0B5MP  DrugCentral
FORODESINE . 135409409  D02ZUO  DGIdb
forodesine . 135409409  D02ZUO  DrugCentral
GUANOSINE . 135398635  D0H1OL  DGIdb
mercaptopurine . 667490  D09UZO  DrugCentral
PELDESINE . 135413525  D08OBT  DGIdb
ULODESINE . 135449518  D02ZKR  DGIdb

Protein Sequence Information

MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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