Host Protein General Information

  Protein Name
Tyrosine-protein kinase ABL1
  Gene Name
ABL1
  Host Species
Homo sapiens
  Uniprot Entry Name
ABL1_HUMAN
  Protein Families
Protein kinase superfamily
  EC Number
2.7.10.2
  Subcellular Location
Cytoplasm; cytoskeleton; Nucleus; Mitochondrion
  External Link
NCBI Gene ID
25
Uniprot ID
P00519
Ensembl ID
ENSG00000097007
HGNC ID
76
  Related KEGG Pathway
Pathogenic Escherichia coli infection hsa05130            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Chemical carcinogenesis - reactive oxygen species hsa05208            Pathway Map 
Chronic myeloid leukemia hsa05220            Pathway Map 
Viral myocarditis hsa05416            Pathway Map 
Cell cycle hsa04110            Pathway Map 
Axon guidance hsa04360            Pathway Map 
Neurotrophin signaling pathway hsa04722            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
Ras signaling pathway hsa04014            Pathway Map 
  3D Structure
PDB ID: 1AB2 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Zika virus 5'UTR RNA Info RNA-protein interaction detection (RaPID) HEK293 Cells (Human embryonic kidney cell) . Kidney 42 h Saint score = 1 .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/Not Specified Virus Strain) N region RNA Info RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) Calu-3 cell line . Liver . P value < 0.05 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ACYCLOVIR . 135398513  D0B5MP  DGIdb
ADAVOSERTIB . 24856436  D02KKA  DGIdb
ADENOSINE TRIPHOSPHATE . 5957  D01BYB  DGIdb
afatinib . 10184653  D05UFG  DrugCentral
ALISERTIB . 24771867  D0S4JK  DGIdb
ALSTERPAULLONE . 5005498  D0H3EV  DGIdb
ASCIMINIB . 72165228  DSHT18  DGIdb
AST-487 . 11409972  D0N7AJ  DGIdb
AXITINIB . 6450551  D01ZRI  DGIdb
axitinib . 6450551  D01ZRI  DrugCentral
AZACITIDINE . 9444  D09FAZ  DGIdb
AZAKENPAULLONE . 6538897  D0DR8N  DGIdb
BAFETINIB . 11387605  D0G0VV  DGIdb
BLINATUMOMAB . . D0K4RK  DGIdb
BOSUTINIB . 5328940  D0OB0F  DGIdb
bosutinib . 5328940  D0OB0F  DrugCentral
BUSULFAN . 2478  D07SUG  DGIdb
CEDIRANIB . 9933475  D09VMI  DGIdb
CELECOXIB . 2662  D03RTS  DGIdb
CEP-11981 . 11751922  D0FD6D  DGIdb
ceritinib . 57379345  D04LVK  DrugCentral
CHEMBL219557 . 11341869  D03MNN  DGIdb
CHEMBL406845 . ?  D06CIJ  DGIdb
crizotinib . 11626560  D03ZBT  DrugCentral
CYC-116 . 6420138  D0CY1B  DGIdb
DASATINIB . 3062316  D0E6XR  DGIdb
dasatinib . 3062316  D0E6XR  DrugCentral
DOVITINIB . 135611162  D07OZR  DGIdb
ENMD-2076 . 16041424  D0S7HM  DGIdb
ENTRECTINIB . 25141092  D0O0LS  DGIdb
ERLOTINIB . 176870  D07POC  DGIdb
erlotinib . 176870  D07POC  DrugCentral
fedratinib . 16722836  D0G8BM  DrugCentral
FLUMATINIB . 46848036  D06JHV  DGIdb
gefitinib . 123631  D09XZB  DrugCentral
GENISTEIN . 5280961  D0L4FS  DGIdb
HYDROXYUREA . 3657  D07CWD  DGIdb
ibrutinib . 24821094  D09KTS  DrugCentral
ILORASERTIB . 46207586  D08HOM  DGIdb
IMATINIB . 5291  D0AZ3C  DGIdb
imatinib . 5291  D0AZ3C  DrugCentral
infigratinib . 53235510  D03LWG  DrugCentral
JNJ-7706621 . 5330790  D04NGS  DGIdb
KENPAULLONE . 3820  D00PWQ  DGIdb
KW-2449 . 11427553  D00ABO  DGIdb
lapatinib . 208908  D08CDI  DrugCentral
MASITINIB . 10074640  D0MW0N  DGIdb
mebendazole . 4030  D0J1MI  DrugCentral
MELPHALAN . 460612  D00FGO  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
MLN-8054 . 11712649  D0A5MC  DGIdb
neratinib . . . DrugCentral
NILOTINIB . 644241  D00STL  DGIdb
nilotinib . 644241  D00STL  DrugCentral
nintedanib . 135423438  D09HNV  DrugCentral
OMACETAXINE MEPESUCCINATE . 285033  D0M4XY  DGIdb
OXALIPLATIN . 9887053  D0Y3ME  DGIdb
PAZOPANIB . . . DGIdb
pazopanib . . . DrugCentral
PD-0166285 . 5311382  D0H8KG  DGIdb
PEXMETINIB . 24765037  D0ML0L  DGIdb
PONATINIB . 24826799  D0H0EQ  DGIdb
ponatinib . 24826799  D0H0EQ  DrugCentral
PROGESTERONE . 5994  D07BSQ  DGIdb
QUERCETIN . 5280343  D0K8KX  DGIdb
quizartinib . 24889392  D07KYT  DrugCentral
radotinib . 16063245  D01NIR  DrugCentral
REBASTINIB . 25066467  D0E0NM  DGIdb
REGORAFENIB . 11167602  D09GDD  DGIdb
ruxolitinib . 25126798  D04LKS  DrugCentral
SARACATINIB . 10302451  D0M0XB  DGIdb
SORAFENIB . 216239  D0W5HK  DGIdb
sorafenib . 216239  D0W5HK  DrugCentral
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb
tofacitinib . 9926791  D0EG1I  DrugCentral
TOZASERTIB . 5494449  D02XNW  DGIdb
VANDETANIB . 3081361  D0G6QF  DGIdb
vandetanib . 3081361  D0G6QF  DrugCentral
VINCRISTINE . 5978  D09QVV  DGIdb
XL-228 . 59757974  D03ZXZ  DGIdb

Protein Sequence Information

MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
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