Host Protein General Information

  Protein Name
Protein-tyrosine phosphatase 1B
  Gene Name
PTPN1
  Host Species
Homo sapiens
  Uniprot Entry Name
PTN1_HUMAN
  Protein Families
Protein-tyrosine phosphatase family, Non-receptor class 1 subfamily
  EC Number
3.1.3.48
  Subcellular Location
Endoplasmic reticulum membrane
  External Link
NCBI Gene ID
5770
Uniprot ID
P18031
Ensembl ID
ENSG00000196396
HGNC ID
9642
  Related KEGG Pathway
Chemical carcinogenesis - reactive oxygen species hsa05208            Pathway Map 
Adherens junction hsa04520            Pathway Map 
Insulin resistance hsa04931            Pathway Map 
Insulin signaling pathway hsa04910            Pathway Map 
  3D Structure
PDB ID: 1A5Y 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 4.8341446 FZR = 0.000696678
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 1.660333987 FZR = 1

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ALDISIN . 3085877  D0TF0V  DGIdb
ALLYL ISOTHIOCYANATE . 5971  D0BQ8Y  DGIdb
aminosalicylic acid . 4649  D01WJL  DrugCentral
benzbromarone . 2333  D0Z3DY  DrugCentral
clodronic acid . 25419  D00HNB  DrugCentral
enoxolone . . . DrugCentral
estramustine phosphate . . . DrugCentral
evans blue . 9409  D0P2CS  DrugCentral
INSULIN . . D0R6CD  DGIdb
OLEANOLIC_ACID . 10494  D0SJ2Q  DGIdb
OLTIPRAZ . 47318  D0W4NM  DGIdb
quercetin . 5280343  D0K8KX  DrugCentral
TILUDRONIC ACID . 60937  D0Q8CS  DGIdb
tiludronic acid . 60937  D0Q8CS  DrugCentral
TRODUSQUEMINE . 9917968  D0O3QW  DGIdb
troglitazone . 5591  D06XZW  DrugCentral
trypan blue . 6296  D03TTQ  DrugCentral
URSOLIC ACID . 64945  D07LUJ  DGIdb

Protein Sequence Information

MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
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