Host Protein General Information

  Protein Name
Tyrosine-protein kinase JAK1
  Gene Name
JAK1
  Host Species
Homo sapiens
  Uniprot Entry Name
JAK1_HUMAN
  Protein Families
Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
  EC Number
2.7.10.2
  Subcellular Location
Endomembrane system; Peripheral membrane protein
  External Link
NCBI Gene ID
3716
Uniprot ID
P23458
Ensembl ID
ENSG00000162434
HGNC ID
6190
  Related KEGG Pathway
NOD-like receptor signaling pathway hsa04621            Pathway Map 
Th1 and Th2 cell differentiation hsa04658            Pathway Map 
Th17 cell differentiation hsa04659            Pathway Map 
Tuberculosis hsa05152            Pathway Map 
Leishmaniasis hsa05140            Pathway Map 
Toxoplasmosis hsa05145            Pathway Map 
Hepatitis C hsa05160            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Measles hsa05162            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Influenza A hsa05164            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Human T-cell leukemia virus 1 infection hsa05166            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Herpes simplex virus 1 infection hsa05168            Pathway Map 
Epstein-Barr virus infection hsa05169            Pathway Map 
Coronavirus disease - COVID-19 hsa05171            Pathway Map 
EGFR tyrosine kinase inhibitor resistance hsa01521            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235            Pathway Map 
Pancreatic cancer hsa05212            Pathway Map 
Necroptosis hsa04217            Pathway Map 
Signaling pathways regulating pluripotency of stem cells hsa04550            Pathway Map 
Osteoclast differentiation hsa04380            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
JAK-STAT signaling pathway hsa04630            Pathway Map 
  3D Structure
PDB ID: 3EYG 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) A549 Cells (Adenocarcinoma human alveolar basal epithelial cell) . Lung . P-value = 4.21792673844655e-06 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 4.21792673844655e-06 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
BARICITINIB . 44205240  D0Y7IC  DGIdb
baricitinib . 44205240  D0Y7IC  DrugCentral
BMS-911543 . 50922691  D0DK8X  DGIdb
CERDULATINIB . 44595079  D0BI3N  DGIdb
ceritinib . 57379345  D04LVK  DrugCentral
crizotinib . 11626560  D03ZBT  DrugCentral
DECERNOTINIB . 59422203  D04QWQ  DGIdb
DELGOCITINIB . 50914062  D05UGH  DGIdb
delgocitinib . 50914062  D05UGH  DrugCentral
entrectinib . 25141092  D0O0LS  DrugCentral
ENZASTAURIN . 176167  D0I6VU  DGIdb
FEDRATINIB . 16722836  D0G8BM  DGIdb
fedratinib . 16722836  D0G8BM  DrugCentral
FILGOTINIB . . . DGIdb
filgotinib . . . DrugCentral
GLPG-0555 . . D0N3YT  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
MOMELOTINIB . 25062766  D0D5ZJ  DGIdb
nintedanib . 135423438  D09HNV  DrugCentral
NS-018 . 46866319  D00MYW  DGIdb
PACRITINIB . 46216796  D0PN8H  DGIdb
PEFICITINIB . 57928403  D06EIC  DGIdb
pralsetinib . 129073603  D0OD2I  DrugCentral
RUXOLITINIB . 25126798  D04LKS  DGIdb
ruxolitinib . 25126798  D04LKS  DrugCentral
RUXOLITINIB PHOSPHATE . 25127112  D0D8KQ  DGIdb
sunitinib . 5329102  D0R0MW  DrugCentral
TOFACITINIB . 9926791  D0EG1I  DGIdb
tofacitinib . 9926791  D0EG1I  DrugCentral
UPADACITINIB . 58557659  D07JAG  DGIdb
upadacitinib . 58557659  D07JAG  DrugCentral

Protein Sequence Information

MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
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