Host Protein General Information

  Protein Name
Ribonucleoside-diphosphate reductase subunit M1
  Gene Name
RRM1
  Host Species
Homo sapiens
  Uniprot Entry Name
RIR1_HUMAN
  Protein Families
Ribonucleoside diphosphate reductase large chain family
  EC Number
1.17.4.1
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
6240
Uniprot ID
P23921
Ensembl ID
ENSG00000167325
HGNC ID
10451
  Related KEGG Pathway
Metabolic pathways hsa01100            Pathway Map 
Nucleotide metabolism hsa01232            Pathway Map 
Glutathione metabolism hsa00480            Pathway Map 
Purine metabolism hsa00230            Pathway Map 
Pyrimidine metabolism hsa00240            Pathway Map 
Drug metabolism - other enzymes hsa00983            Pathway Map 
  3D Structure
PDB ID: 2WGH 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -16.48214104 FZR = 6.05001E-58
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -5.088661698 FZR = 0.000371417

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
CISPLATIN . 5702198  D0U5HU  DGIdb
CLADRIBINE . 20279  D05GJW  DGIdb
CLOFARABINE . 119182  D0R5RR  DGIdb
clofarabine . 119182  D0R5RR  DrugCentral
CYTARABINE . 6253  D07XSN  DGIdb
DOCETAXEL . 148124  D0O5WP  DGIdb
FLUDARABINE . 657237  D0F2XQ  DGIdb
FLUDARABINE PHOSPHATE . 30751  D0TO2R  DGIdb
fludarabine phosphate . 30751  D0TO2R  DrugCentral
GALLIUM NITRATE . 61635  D0R4ZT  DGIdb
GEMCITABINE . 60750  D03UVS  DGIdb
gemcitabine . 60750  D03UVS  DrugCentral
GEMCITABINE HYDROCHLORIDE . 60750  D03UVS  DGIdb
hydroxycarbamide . 3657  D07CWD  DrugCentral
HYDROXYUREA . 3657  D07CWD  DGIdb
PACLITAXEL . . . DGIdb
TEZACITABINE . 6435808  D05HZI  DGIdb
vidarabine . 21704  D0NI0C  DrugCentral
VINORELBINE . 5311497  D01HTL  DGIdb

Protein Sequence Information

MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS
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