Host Protein General Information

  Protein Name
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
  Gene Name
PDE4A
  Host Species
Homo sapiens
  Uniprot Entry Name
PDE4A_HUMAN
  Protein Families
Cyclic nucleotide phosphodiesterase family, PDE4 subfamily
  EC Number
3.1.4.53
  Subcellular Location
Cytoplasm; perinuclear region
  External Link
NCBI Gene ID
5141
Uniprot ID
P27815
Ensembl ID
ENSG00000196510
HGNC ID
8780
  Related KEGG Pathway
Purine metabolism hsa00230            Pathway Map 
Metabolic pathways hsa01100            Pathway Map 
cAMP signaling pathway hsa04024            Pathway Map 
Parathyroid hormone synthesis, secretion and action hsa04928            Pathway Map 
Morphine addiction hsa05032            Pathway Map 
  3D Structure
PDB ID: 2QYK 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 1.30129809 FZR = 1
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -3.547606841 FZR = 0.312942176

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
AMINOPHYLLINE . 9433  D03TYI  DGIdb
AMLEXANOX . 2161  D0G5UB  DGIdb
APREMILAST . 11561674  D07ESC  DGIdb
apremilast . 11561674  D07ESC  DrugCentral
AROFYLLINE . 166553  D0T0NG  DGIdb
benzbromarone . 2333  D0Z3DY  DrugCentral
CDC-801 . 9844338  D0U2DH  DGIdb
CDP840 . 127928  D0UG4T  DGIdb
celecoxib . 2662  D03RTS  DrugCentral
chlortetracycline . 54675777  D0R6RC  DrugCentral
cladribine . 20279  D05GJW  DrugCentral
CRISABOROLE . 44591583  D08NWF  DGIdb
DENBUFYLLINE . 2984  D01XHG  DGIdb
DIPYRIDAMOLE . 3108  D0F9GE  DGIdb
dipyridamole . 3108  D0F9GE  DrugCentral
disulfiram . 3117  D0X5SD  DrugCentral
DYPHYLLINE . 3182  D02PWM  DGIdb
ENPROFYLLINE . 1676  D09AMZ  DGIdb
ETAZOLATE . 3277  D0J6LN  DGIdb
GSK-356278 . 10252640  D0K9DI  DGIdb
HT-0712 . 9865375  D07OCV  DGIdb
IBUDILAST . 3671  D03QJL  DGIdb
ibudilast . 3671  D03QJL  DrugCentral
LIRIMILAST . 6433118  D0F5IY  DGIdb
LOTAMILAST . 24864553  D0TT4H  DGIdb
MILRINONE . 4197  D0Y9ZE  DGIdb
MK-0873 . 9919680  D0M7CB  DGIdb
nifedipine . 4485  D04OSE  DrugCentral
nimesulide . 4495  D0C0JT  DrugCentral
OGLEMILAST . 11387409  D0L8KJ  DGIdb
OXTRIPHYLLINE . 656652  D0B0SH  DGIdb
papaverine . 4680  D0NJ3V  DrugCentral
PENTOXIFYLLINE . 4740  D09QEI  DGIdb
PICLAMILAST . 154575  D0Z2FB  DGIdb
REVAMILAST . 11546664  D0X0PW  DGIdb
ROFLUMILAST . 449193  D0R4UW  DGIdb
roflumilast . 449193  D0R4UW  DrugCentral
ROLIPRAM . 5092  D0T5PO  DGIdb
TADALAFIL . 110635  D05MQK  DGIdb
THEOPHYLLINE . 2153  D0F8RA  DGIdb
theophylline . 2153  D0F8RA  DrugCentral
TOFIMILAST . 9896267  D09TFB  DGIdb

Protein Sequence Information

MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
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