Host Protein General Information

  Protein Name
Mitogen-activated protein kinase 1
  Gene Name
MAPK1
  Host Species
Homo sapiens
  Uniprot Entry Name
MK01_HUMAN
  Protein Families
Protein kinase superfamily
  EC Number
2.7.11.24
  Subcellular Location
Cytoplasm; cytoskeleton; spindle
  External Link
NCBI Gene ID
5594
Uniprot ID
P28482
Ensembl ID
ENSG00000100030
HGNC ID
6871
  Related KEGG Pathway
Chemokine signaling pathway hsa04062            Pathway Map 
Platelet activation hsa04611            Pathway Map 
Neutrophil extracellular trap formation hsa04613            Pathway Map 
Toll-like receptor signaling pathway hsa04620            Pathway Map 
NOD-like receptor signaling pathway hsa04621            Pathway Map 
C-type lectin receptor signaling pathway hsa04625            Pathway Map 
Natural killer cell mediated cytotoxicity hsa04650            Pathway Map 
IL-17 signaling pathway hsa04657            Pathway Map 
Th1 and Th2 cell differentiation hsa04658            Pathway Map 
Th17 cell differentiation hsa04659            Pathway Map 
T cell receptor signaling pathway hsa04660            Pathway Map 
B cell receptor signaling pathway hsa04662            Pathway Map 
Fc epsilon RI signaling pathway hsa04664            Pathway Map 
Fc gamma R-mediated phagocytosis hsa04666            Pathway Map 
Pathogenic Escherichia coli infection hsa05130            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Salmonella infection hsa05132            Pathway Map 
Pertussis hsa05133            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Tuberculosis hsa05152            Pathway Map 
Leishmaniasis hsa05140            Pathway Map 
Chagas disease hsa05142            Pathway Map 
Toxoplasmosis hsa05145            Pathway Map 
Hepatitis C hsa05160            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Influenza A hsa05164            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Human T-cell leukemia virus 1 infection hsa05166            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
Coronavirus disease - COVID-19 hsa05171            Pathway Map 
EGFR tyrosine kinase inhibitor resistance hsa01521            Pathway Map 
Endocrine resistance hsa01522            Pathway Map 
Platinum drug resistance hsa01524            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Chemical carcinogenesis - receptor activation hsa05207            Pathway Map 
Chemical carcinogenesis - reactive oxygen species hsa05208            Pathway Map 
Central carbon metabolism in cancer hsa05230            Pathway Map 
Choline metabolism in cancer hsa05231            Pathway Map 
PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235            Pathway Map 
Colorectal cancer hsa05210            Pathway Map 
Renal cell carcinoma hsa05211            Pathway Map 
Pancreatic cancer hsa05212            Pathway Map 
Endometrial cancer hsa05213            Pathway Map 
Glioma hsa05214            Pathway Map 
Prostate cancer hsa05215            Pathway Map 
Thyroid cancer hsa05216            Pathway Map 
Melanoma hsa05218            Pathway Map 
Bladder cancer hsa05219            Pathway Map 
Chronic myeloid leukemia hsa05220            Pathway Map 
Acute myeloid leukemia hsa05221            Pathway Map 
Non-small cell lung cancer hsa05223            Pathway Map 
Breast cancer hsa05224            Pathway Map 
Hepatocellular carcinoma hsa05225            Pathway Map 
Gastric cancer hsa05226            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Oocyte meiosis hsa04114            Pathway Map 
Apoptosis hsa04210            Pathway Map 
Cellular senescence hsa04218            Pathway Map 
Regulation of actin cytoskeleton hsa04810            Pathway Map 
Focal adhesion hsa04510            Pathway Map 
Adherens junction hsa04520            Pathway Map 
Gap junction hsa04540            Pathway Map 
Signaling pathways regulating pluripotency of stem cells hsa04550            Pathway Map 
Adrenergic signaling in cardiomyocytes hsa04261            Pathway Map 
Vascular smooth muscle contraction hsa04270            Pathway Map 
Axon guidance hsa04360            Pathway Map 
Osteoclast differentiation hsa04380            Pathway Map 
Type II diabetes mellitus hsa04930            Pathway Map 
AGE-RAGE signaling pathway in diabetic complications hsa04933            Pathway Map 
Cushing syndrome hsa04934            Pathway Map 
Insulin signaling pathway hsa04910            Pathway Map 
GnRH signaling pathway hsa04912            Pathway Map 
Progesterone-mediated oocyte maturation hsa04914            Pathway Map 
Estrogen signaling pathway hsa04915            Pathway Map 
Melanogenesis hsa04916            Pathway Map 
Prolactin signaling pathway hsa04917            Pathway Map 
Thyroid hormone signaling pathway hsa04919            Pathway Map 
Oxytocin signaling pathway hsa04921            Pathway Map 
Relaxin signaling pathway hsa04926            Pathway Map 
Parathyroid hormone synthesis, secretion and action hsa04928            Pathway Map 
GnRH secretion hsa04929            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
Circadian entrainment hsa04713            Pathway Map 
Aldosterone-regulated sodium reabsorption hsa04960            Pathway Map 
Long-term potentiation hsa04720            Pathway Map 
Neurotrophin signaling pathway hsa04722            Pathway Map 
Retrograde endocannabinoid signaling hsa04723            Pathway Map 
Glutamatergic synapse hsa04724            Pathway Map 
Cholinergic synapse hsa04725            Pathway Map 
Serotonergic synapse hsa04726            Pathway Map 
Long-term depression hsa04730            Pathway Map 
Alzheimer disease hsa05010            Pathway Map 
Prion disease hsa05020            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
MAPK signaling pathway hsa04010            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
Ras signaling pathway hsa04014            Pathway Map 
Rap1 signaling pathway hsa04015            Pathway Map 
cGMP-PKG signaling pathway hsa04022            Pathway Map 
cAMP signaling pathway hsa04024            Pathway Map 
HIF-1 signaling pathway hsa04066            Pathway Map 
FoxO signaling pathway hsa04068            Pathway Map 
Sphingolipid signaling pathway hsa04071            Pathway Map 
Phospholipase D signaling pathway hsa04072            Pathway Map 
mTOR signaling pathway hsa04150            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
TGF-beta signaling pathway hsa04350            Pathway Map 
VEGF signaling pathway hsa04370            Pathway Map 
Apelin signaling pathway hsa04371            Pathway Map 
TNF signaling pathway hsa04668            Pathway Map 
Alcoholism hsa05034            Pathway Map 
Autophagy - animal hsa04140            Pathway Map 
  3D Structure
PDB ID: 1PME 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -4.727790429 FZR = 0.0011485
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 1.787325221 FZR = 1
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/USA/WA1/2020) Not Specified Virus Region RNA Info ChIRP-MS Huh7.5 cells (Hepatocyte derived cellular carcinoma cell) . Liver 48 h FDR <= 0.05 .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
aceclofenac . 71771  D0T8VY  DrugCentral
ALPHA-NAPHTHOFLAVONE . 11790  D0I7GE  DGIdb
ALSTERPAULLONE . 5005498  D0H3EV  DGIdb
benzbromarone . 2333  D0Z3DY  DrugCentral
BIOCHANIN . 5280373  D0S9YX  DGIdb
BISINDOLYLMALEIMIDE IX . 5083  D0M5FF  DGIdb
bithionol . 2406  D0QQ1J  DrugCentral
BUMETANIDE . 2471  D0R7HO  DGIdb
CANTHARIDIN . 5944  D0Z2RA  DGIdb
CHEMBL184074 . 9806489  D0P0FN  DGIdb
CHEMBL210618 . 11624601  D00HVA  DGIdb
CHEMBL225519 . 11715767  D03DZO  DGIdb
CHEMBL35482 . 4713  D9ILC1  DGIdb
CHEMBL429095 . 262093  D0J1KH  DGIdb
CHIR-99021 . 9956119  D0YK9D  DGIdb
CHLORANIL . 8371  D0D0BI  DGIdb
CI-1040 . 6918454  D0B9BU  DGIdb
CLIOQUINOL . 2788  D06ABW  DGIdb
CLOTRIMAZOLE . 2812  D09GOS  DGIdb
DAPH . 1697  D03QTP  DGIdb
dicoumarol . 54676038  D02TJS  DrugCentral
diiodohydroxyquinoline . 3728  D06AEB  DrugCentral
ELLAGIC ACID . 5281855  D0A1CM  DGIdb
ERLOTINIB . 176870  D07POC  DGIdb
ETOPOSIDE . 36462  D0B7EB  DGIdb
exisulind . 5472495  D0M9VE  DrugCentral
FISETIN . 5281614  D0MF5Y  DGIdb
GENTIAN VIOLET . 11057  D04GZA  DGIdb
GF-109203 . 2396  D0TO6S  DGIdb
GO-6976 . 3501  D08JPU  DGIdb
GOSSYPOL . 3503  D0Z0HH  DGIdb
GR-127935 . 107780  D06DZI  DGIdb
hexachlorophene . 3598  D0ZX2G  DrugCentral
INDIRUBIN-3-MONOXIME . 3707  D0Y0ES  DGIdb
IPRIFLAVONE . 3747  D0R2OA  DGIdb
IROFULVEN . 148189  D00EPT  DGIdb
isotretinoin . 5282379  D00DKK  DrugCentral
ISOVELLERAL . 37839  D0MZ7C  DGIdb
LEVODOPA . 6047  D08HVR  DGIdb
LITHOCHOLIC ACID . 9903  D04SLF  DGIdb
LORATADINE . 3957  D06ABF  DGIdb
meclofenamic acid . 4037  D08IFL  DrugCentral
MERCURIC CHLORIDE . . . DGIdb
MIBEFRADIL . 60663  D0W8XT  DGIdb
MITOXANTRONE . 4212  D0R3JB  DGIdb
MK-8353 . 58282870  D0L1GD  DGIdb
NAFTOPIDIL . 4418  D04DKH  DGIdb
nalfurafine . . . DrugCentral
NECA . 448222  D0K8ZZ  DGIdb
NIFEDIPINE . 4485  D04OSE  DGIdb
PATULIN . 4696  D0LB4A  DGIdb
PD-169316 . 4712  D0W3ZN  DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
PHENMEDIPHAM . 24744  D07PAF  DGIdb
PIMOZIDE . 16362  D00KHM  DGIdb
PLUMBAGIN . 10205  D0P0IE  DGIdb
PROGESTERONE . 5994  D07BSQ  DGIdb
PURPURIN . 6683  D0XJ7I  DGIdb
R-1487 . 11406590  D04YHW  DGIdb
REBAMIPIDE . 5042  D03BQP  DGIdb
RELCOVAPTAN . 60943  D0I8ZZ  DGIdb
SANGUINARIUM . 5154  D0T3NB  DGIdb
SB-202190 . 5169  D0VC0I  DGIdb
SB-203580 . 176155  D0F8DL  DGIdb
SB-220025 . 5164  D09ICC  DGIdb
SORAFENIB . 216239  D0W5HK  DGIdb
sorafenib . 216239  D0W5HK  DrugCentral
SP-600125 . 8515  D02PVB  DGIdb
sulfasalazine . 5339  D02ZTJ  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb
tannic acid . 16129778  D0R4WJ  DrugCentral
tretinoin . 444795  D02DGU  DrugCentral
TRIFLUOPERAZINE . 5566  D0R4OM  DGIdb
troglitazone . 5591  D06XZW  DrugCentral
TYRPHOSTIN AG-1478 . 2051  D0ZH1U  DGIdb
U-0126 . 3006531  D0GD8Y  DGIdb
URACIL . 1174  D0Y0DG  DGIdb
WEDELOLACTONE . 5281813  D0F8QJ  DGIdb
WITHAFERIN A . 265237  D0V3PN  DGIdb
ZAFIRLUKAST . 5717  D05DVP  DGIdb
zafirlukast . 5717  D05DVP  DrugCentral
ZALCITABINE . 24066  D0Z9QR  DGIdb

Protein Sequence Information

MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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