Host Protein General Information

  Protein Name
Prostaglandin G/H synthase 2
  Gene Name
PTGS2
  Host Species
Homo sapiens
  Uniprot Entry Name
PGH2_HUMAN
  Protein Families
Prostaglandin G/H synthase family
  EC Number
1.14.99.1
  Subcellular Location
Microsome membrane
  External Link
NCBI Gene ID
5743
Uniprot ID
P35354
Ensembl ID
ENSG00000073756
HGNC ID
9605
  Related KEGG Pathway
C-type lectin receptor signaling pathway hsa04625            Pathway Map 
IL-17 signaling pathway hsa04657            Pathway Map 
Leishmaniasis hsa05140            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Chemical carcinogenesis - DNA adducts hsa05204            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Small cell lung cancer hsa05222            Pathway Map 
Ovarian steroidogenesis hsa04913            Pathway Map 
Oxytocin signaling pathway hsa04921            Pathway Map 
Regulation of lipolysis in adipocytes hsa04923            Pathway Map 
Metabolic pathways hsa01100            Pathway Map 
Arachidonic acid metabolism hsa00590            Pathway Map 
Retrograde endocannabinoid signaling hsa04723            Pathway Map 
Serotonergic synapse hsa04726            Pathway Map 
Alzheimer disease hsa05010            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
NF-kappa B signaling pathway hsa04064            Pathway Map 
VEGF signaling pathway hsa04370            Pathway Map 
TNF signaling pathway hsa04668            Pathway Map 
  3D Structure
PDB ID: 5F19 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -3.67925785 FZR = 0.094033297
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -0.931397405 FZR = 1

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
aceclofenac . 71771  D0T8VY  DrugCentral
acemetacin . . . DrugCentral
ACETAMINOPHEN . 1983  D0U5QK  DGIdb
acetylsalicylic acid . 2244  D0GY5Z  DrugCentral
alclofenac . 30951  D0C6OQ  DrugCentral
aminophenazone . . . DrugCentral
AMINOSALICYLATE SODIUM . 4649  D01WJL  DGIdb
APRICOXIB . 9820073  D0S7IZ  DGIdb
ASPIRIN . 2244  D0GY5Z  DGIdb
ATENOLOL . 2249  D01UXC  DGIdb
BALSALAZIDE . 54585  D0A6KR  DGIdb
balsalazide . 54585  D0A6KR  DrugCentral
BALSALAZIDE DISODIUM . 54585  D0A6KR  DGIdb
BENZQUINAMIDE . 2342  D02DKD  DGIdb
benzquinamide . 2342  D02DKD  DrugCentral
BISMUTH SUBSALICYLATE . . . DGIdb
BROMFENAC . 60726  D0U1OM  DGIdb
bromfenac . 60726  D0U1OM  DrugCentral
BROMFENAC SODIUM . 60726  D0U1OM  DGIdb
CAPECITABINE . 60953  D00HCQ  DGIdb
captopril . 44093  D0I0EG  DrugCentral
CARPROFEN . 2581  D0IT2X  DGIdb
carprofen . 2581  D0IT2X  DrugCentral
cefalotin . 6024  D01PLN  DrugCentral
cefonicid . 43594  D01BQC  DrugCentral
cefotetan . 53025  D0AP9T  DrugCentral
CELECOXIB . 2662  D03RTS  DGIdb
celecoxib . 2662  D03RTS  DrugCentral
cianidanol . 9064  D0V7AA  DrugCentral
CIMICOXIB . 213053  D0U8OD  DGIdb
clotrimazole . 2812  D09GOS  DrugCentral
CURCUMIN . 969516  D07SDQ  DGIdb
DARBUFELONE . 6444826  D0AL8T  DGIdb
DERSALAZINE . 135484128  D0ZI0C  DGIdb
dexamethasone . 5743  D0IT2G  DrugCentral
DEXIBUPROFEN . 39912  D06YPU  DGIdb
dexibuprofen . 39912  D06YPU  DrugCentral
dexketoprofen . . . DrugCentral
DICLOFENAC . 3033  D0TG1H  DGIdb
diclofenac . 3033  D0TG1H  DrugCentral
DIFLUNISAL . 3059  D08LFZ  DGIdb
diflunisal . 3059  D08LFZ  DrugCentral
ESFLURBIPROFEN . 72099  D0G2IC  DGIdb
esflurbiprofen . 72099  D0G2IC  DrugCentral
ETODOLAC . 3308  D0N1WU  DGIdb
etodolac . 3308  D0N1WU  DrugCentral
ETORICOXIB . 123619  D09MGR  DGIdb
etoricoxib . 123619  D09MGR  DrugCentral
felbinac . 3332  D0Y7EM  DrugCentral
FENBUFEN . 3335  D06LHG  DGIdb
fenbufen . 3335  D06LHG  DrugCentral
FENOPROFEN . 3342  D03XYW  DGIdb
fenoprofen . 3342  D03XYW  DrugCentral
FENOPROFEN CALCIUM . 3342  D03XYW  DGIdb
floctafenine . 3360  D0AK5R  DrugCentral
flufenamic acid . 3371  D0B2WJ  DrugCentral
fluostigmine . 5936  D0B2OT  DrugCentral
FLURBIPROFEN . 3394  D0A1PX  DGIdb
flurbiprofen . 3394  D0A1PX  DrugCentral
FLURBIPROFEN SODIUM . 3394  D0A1PX  DGIdb
GW-406381 . 9832687  D00RSK  DGIdb
hexachlorophene . 3598  D0ZX2G  DrugCentral
HYDROXYCHLOROQUINE . 3652  D0OJ4L  DGIdb
IBUPROFEN . 3672  D0R1QE  DGIdb
ibuprofen . 3672  D0R1QE  DrugCentral
IMRECOXIB . 11682175  D0AL8M  DGIdb
imrecoxib . 11682175  D0AL8M  DrugCentral
indobufen . . . DrugCentral
INDOMETHACIN . 3715  D0R1RS  DGIdb
indomethacin . 3715  D0R1RS  DrugCentral
isoxicam . 54677972  D03JPH  DrugCentral
KETOPROFEN . 3825  D0W9WF  DGIdb
ketoprofen . 3825  D0W9WF  DrugCentral
KETOROLAC . 3826  D0D9JW  DGIdb
ketorolac . 3826  D0D9JW  DrugCentral
LICOFELONE . 133021  D0N1SU  DGIdb
loxoprofen . 3965  D0LR4B  DrugCentral
LUMIRACOXIB . 151166  D04YMH  DGIdb
lumiracoxib . 151166  D04YMH  DrugCentral
MECLOFENAMATE SODIUM . 4038  D0MN9K  DGIdb
meclofenamic acid . 4037  D08IFL  DrugCentral
MEFENAMIC ACID . 4044  D05FTJ  DGIdb
mefenamic acid . 4044  D05FTJ  DrugCentral
MELOXICAM . 54677470  D0G7FJ  DGIdb
meloxicam . 54677470  D0G7FJ  DrugCentral
MESALAMINE . 4075  D0C4YC  DGIdb
mesalazine . 4075  D0C4YC  DrugCentral
mezlocillin . 656511  D00NJJ  DrugCentral
miconazole . 4189  D00AXJ  DrugCentral
mofezolac . . . DrugCentral
monobenzone . 7638  D0H6TP  DrugCentral
NABUMETONE . 4409  D05CKR  DGIdb
nabumetone . 4409  D05CKR  DrugCentral
NAPROXCINOD . 9884642  D0U5OU  DGIdb
NAPROXEN . 156391  D0DJ1B  DGIdb
naproxen . 156391  D0DJ1B  DrugCentral
NAPROXEN ETEMESIL . 25170420  D0G0YL  DGIdb
NEPAFENAC . 151075  D02IHW  DGIdb
nepafenac . 151075  D02IHW  DrugCentral
niflumic acid . 4488  D00HGB  DrugCentral
NIMESULIDE . 4495  D0C0JT  DGIdb
nimesulide . 4495  D0C0JT  DrugCentral
nitroxoline . . . DrugCentral
NS-398 . 4553  D09BKE  DGIdb
OLSALAZINE SODIUM . 22419  D00KRE  DGIdb
oxacillin . 6196  D0MB8I  DrugCentral
OXALIPLATIN . 9887053  D0Y3ME  DGIdb
OXAPROZIN . 4614  D0M9DC  DGIdb
oxaprozin . 4614  D0M9DC  DrugCentral
OXYPHENBUTAZONE . 4641  D06ZPS  DGIdb
paracetamol . 1983  D0U5QK  DrugCentral
PARECOXIB . 119828  D05UWI  DGIdb
parecoxib . 119828  D05UWI  DrugCentral
PHENYLBUTAZONE . 4781  D07VHR  DGIdb
piketoprofen . . . DrugCentral
PIROXICAM . 54676228  D00IBN  DGIdb
piroxicam . 54676228  D00IBN  DrugCentral
pirprofen . 35935  D0S9ET  DrugCentral
POLMACOXIB . 9841854  D0W2CX  DGIdb
polmacoxib . 9841854  D0W2CX  DrugCentral
proquazone . 31508  D0J6WW  DrugCentral
quercetin . 5280343  D0K8KX  DrugCentral
RALOXIFENE . 5035  D01XBA  DGIdb
RESERPINE . 5770  D0J4JM  DGIdb
RESVERATROL . 445154  D0U3EP  DGIdb
ROFECOXIB . 5090  D05VLS  DGIdb
rofecoxib . 5090  D05VLS  DrugCentral
RWJ-67657 . 3008319  D06OZJ  DGIdb
SALSALATE . 5161  D0Y0JH  DGIdb
SC-560 . 4306515  D0M5MI  DGIdb
SULFASALAZINE . 5339  D02ZTJ  DGIdb
SULINDAC . 1548887  D0Z5IU  DGIdb
sulindac . 1548887  D0Z5IU  DrugCentral
SUPROFEN . 5359  D07BPS  DGIdb
suprofen . 5359  D07BPS  DrugCentral
tamoxifen . 2733526  D07KSG  DrugCentral
tenidap . 60712  D02RQT  DrugCentral
TENOXICAM . 54677971  D0I6IB  DGIdb
tenoxicam . 54677971  D0I6IB  DrugCentral
THALIDOMIDE . 5426  D0U7GK  DGIdb
thalidomide . 5426  D0U7GK  DrugCentral
tiaprofenic acid . 5468  D0S7VO  DrugCentral
ticlopidine . 5472  D05LBU  DrugCentral
tolfenamic acid . . . DrugCentral
TOLMETIN . 5509  D09BHB  DGIdb
tolmetin . 5509  D09BHB  DrugCentral
URSOLIC ACID . 64945  D07LUJ  DGIdb
VALDECOXIB . 119607  D0L6DA  DGIdb
valdecoxib . 119607  D0L6DA  DrugCentral
VB-201 . 45138527  D0N2IE  DGIdb
zomepirac . 5733  D0SU1G  DrugCentral

Protein Sequence Information

MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
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