Host Protein General Information

  Protein Name
Acute-phase response factor
  Gene Name
STAT3
  Host Species
Homo sapiens
  Uniprot Entry Name
STAT3_HUMAN
  Protein Families
Transcription factor STAT family
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
6774
Uniprot ID
P40763
Ensembl ID
ENSG00000168610
HGNC ID
11364
  Related KEGG Pathway
Chemokine signaling pathway hsa04062            Pathway Map 
Th17 cell differentiation hsa04659            Pathway Map 
Toxoplasmosis hsa05145            Pathway Map 
Hepatitis C hsa05160            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Measles hsa05162            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Epstein-Barr virus infection hsa05169            Pathway Map 
Coronavirus disease - COVID-19 hsa05171            Pathway Map 
Inflammatory bowel disease hsa05321            Pathway Map 
EGFR tyrosine kinase inhibitor resistance hsa01521            Pathway Map 
HIF-1 signaling pathway hsa04066            Pathway Map 
FoxO signaling pathway hsa04068            Pathway Map 
Necroptosis hsa04217            Pathway Map 
Signaling pathways regulating pluripotency of stem cells hsa04550            Pathway Map 
JAK-STAT signaling pathway hsa04630            Pathway Map 
Prolactin signaling pathway hsa04917            Pathway Map 
Adipocytokine signaling pathway hsa04920            Pathway Map 
Insulin resistance hsa04931            Pathway Map 
AGE-RAGE signaling pathway in diabetic complications hsa04933            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Chemical carcinogenesis - receptor activation hsa05207            Pathway Map 
Pancreatic cancer hsa05212            Pathway Map 
Acute myeloid leukemia hsa05221            Pathway Map 
Non-small cell lung cancer hsa05223            Pathway Map 
PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
  3D Structure
PDB ID: 5AX3 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) A549 Cells (Adenocarcinoma human alveolar basal epithelial cell) . Lung . P-value = 3.48951413742594e-05 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 3.48951413742594e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 0.0211218001382698 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h P = 0.00125269869614294 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h P = 0.000935801102509259 .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ACITRETIN . 5284513  D05QDC  DGIdb
ATIPRIMOD . 129869  D0D9LJ  DGIdb
BARDOXOLONE METHYL . 400769  D0JU5X  DGIdb
CELECOXIB . 2662  D03RTS  DGIdb
CIGLITAZONE . 2750  D03GWY  DGIdb
DIGITOXIN . 441207  D0M3QP  DGIdb
digitoxin . 441207  D0M3QP  DrugCentral
DIGOXIN . 2724385  D02OZE  DGIdb
digoxin . 2724385  D02OZE  DrugCentral
GOLOTIMOD . 6992140  D02MRN  DGIdb
levomenol . . . DrugCentral
NICLOSAMIDE . 4477  D0J9ZR  DGIdb
niclosamide . 4477  D0J9ZR  DrugCentral
nifuroxazide . . . DrugCentral
OUABAIN . 439501  D0AR3J  DGIdb
ouabain . 439501  D0AR3J  DrugCentral
PYRIMETHAMINE . 4993  D0C0SK  DGIdb

Protein Sequence Information

MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
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