Host Protein General Information

  Protein Name
Glutamate--cysteine ligase regulatory subunit
  Gene Name
GCLM
  Host Species
Homo sapiens
  Uniprot Entry Name
GSH0_HUMAN
  Protein Families
Aldo/keto reductase family, Glutamate--cysteine ligase light chain subfamily
  External Link
NCBI Gene ID
2730
Uniprot ID
P48507
Ensembl ID
ENSG00000023909
HGNC ID
4312
  Related KEGG Pathway
Cysteine and methionine metabolism hsa00270            Pathway Map 
Ferroptosis hsa04216            Pathway Map 
Metabolic pathways hsa01100            Pathway Map 
Biosynthesis of cofactors hsa01240            Pathway Map 
Glutathione metabolism hsa00480            Pathway Map 
  3D Structure
AlphaFold ID: P48507 
  2D PNG Download  
  mmCIF File Download   
  PDB File Download   

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -3.981139528 FZR = 0.030177696
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -0.721874111 FZR = 1

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
CISPLATIN . 5702198  D0U5HU  DGIdb
MELATONIN . 896  D0AN7B  DGIdb
SULFORAPHANE . 5350  D0X4IO  DGIdb

Protein Sequence Information

MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
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