Host Protein General Information

  Protein Name
Glycogen synthase kinase-3 beta
  Gene Name
GSK3B
  Host Species
Homo sapiens
  Uniprot Entry Name
GSK3B_HUMAN
  Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, GSK-3 subfamily
  EC Number
2.7.11.1; 2.7.11.26
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
2932
Uniprot ID
P49841
Ensembl ID
ENSG00000082701
HGNC ID
4617
  Related KEGG Pathway
Chemokine signaling pathway hsa04062            Pathway Map 
IL-17 signaling pathway hsa04657            Pathway Map 
T cell receptor signaling pathway hsa04660            Pathway Map 
B cell receptor signaling pathway hsa04662            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Hepatitis C hsa05160            Pathway Map 
Measles hsa05162            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
EGFR tyrosine kinase inhibitor resistance hsa01521            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Colorectal cancer hsa05210            Pathway Map 
Endometrial cancer hsa05213            Pathway Map 
Prostate cancer hsa05215            Pathway Map 
Basal cell carcinoma hsa05217            Pathway Map 
Breast cancer hsa05224            Pathway Map 
Hepatocellular carcinoma hsa05225            Pathway Map 
Gastric cancer hsa05226            Pathway Map 
Diabetic cardiomyopathy hsa05415            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Cell cycle hsa04110            Pathway Map 
Focal adhesion hsa04510            Pathway Map 
Signaling pathways regulating pluripotency of stem cells hsa04550            Pathway Map 
Axon guidance hsa04360            Pathway Map 
Insulin resistance hsa04931            Pathway Map 
Non-alcoholic fatty liver disease hsa04932            Pathway Map 
Cushing syndrome hsa04934            Pathway Map 
Alcoholic liver disease hsa04936            Pathway Map 
Insulin signaling pathway hsa04910            Pathway Map 
Melanogenesis hsa04916            Pathway Map 
Prolactin signaling pathway hsa04917            Pathway Map 
Thyroid hormone signaling pathway hsa04919            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
Neurotrophin signaling pathway hsa04722            Pathway Map 
Dopaminergic synapse hsa04728            Pathway Map 
Alzheimer disease hsa05010            Pathway Map 
Prion disease hsa05020            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
mTOR signaling pathway hsa04150            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
Wnt signaling pathway hsa04310            Pathway Map 
Hedgehog signaling pathway hsa04340            Pathway Map 
Hippo signaling pathway hsa04390            Pathway Map 
  3D Structure
PDB ID: 1GNG 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 2.42261505 FZR = 1
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 2.329406202 FZR = 1

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ALSTERPAULLONE . 5005498  D0H3EV  DGIdb
AZAKENPAULLONE . 6538897  D0DR8N  DGIdb
AZD-1080 . 135564570  D0MC0O  DGIdb
BETA-SITOSTEROL . 222284  D0Y7LD  DGIdb
BETULINIC ACID . 64971  D0R9YR  DGIdb
BMS-387032 . 3025986  D0S5RC  DGIdb
BX-795 . 10077147  D0RG0Z  DGIdb
CEP-11981 . 11751922  D0FD6D  DGIdb
CHEMBL225519 . 11715767  D03DZO  DGIdb
CHEMBL259850 . 448014  D0A3MV  DGIdb
CHEMBL322970 . 4210951  D0N4WB  DGIdb
CHIR-99021 . 9956119  D0YK9D  DGIdb
CI-1040 . 6918454  D0B9BU  DGIdb
CITALOPRAM . 2771  D0Y5DO  DGIdb
CYC-116 . 6420138  D0CY1B  DGIdb
FLUOXETINE . 3386  D0TR5X  DGIdb
GO-6976 . 3501  D08JPU  DGIdb
GSK-269962A . 16095342  D02ZQS  DGIdb
hesperetin . 72281  D07MGA  DrugCentral
ISOGRANULATIMIDE . 135418335  D0Z2CN  DGIdb
JNJ-7706621 . 5330790  D04NGS  DGIdb
KENPAULLONE . 3820  D00PWQ  DGIdb
LITHIUM . 3028194  D5MF8Y  DGIdb
LITHIUM CARBONATE . 11125  D04UUH  DGIdb
LITHIUM CITRATE . 13520  D0Q4EW  DGIdb
LY-2090314 . 10029385  D0Z1DH  DGIdb
MANZAMINE A . 6509753  D0Q4QF  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
niclosamide . 4477  D0J9ZR  DrugCentral
nintedanib . 135423438  D09HNV  DrugCentral
OLEANOLIC_ACID . 10494  D0SJ2Q  DGIdb
PALBINONE . 9841735  D03DEO  DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
quercetin . 5280343  D0K8KX  DrugCentral
RGB-286638 . 11285001  D03DKV  DGIdb
ruboxistaurin . 153999  D0W3LI  DrugCentral
SB-203580 . 176155  D0F8DL  DGIdb
SB-216763 . 176158  D0A1YQ  DGIdb
SP-600125 . 8515  D02PVB  DGIdb
TIDEGLUSIB . 11313622  D0UT7X  DGIdb
URSOLIC ACID . 64945  D07LUJ  DGIdb

Protein Sequence Information

MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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