Host Protein General Information

  Protein Name
HMG-CoA synthase
  Gene Name
HMGCS2
  Host Species
Homo sapiens
  Uniprot Entry Name
HMCS2_HUMAN
  Protein Families
Thiolase-like superfamily, HMG-CoA synthase family
  EC Number
2.3.3.10
  Subcellular Location
Mitochondrion
  External Link
NCBI Gene ID
3158
Uniprot ID
P54868
Ensembl ID
ENSG00000134240
HGNC ID
5008
  Related KEGG Pathway
Valine, leucine and isoleucine degradation hsa00280            Pathway Map 
Butanoate metabolism hsa00650            Pathway Map 
PPAR signaling pathway hsa03320            Pathway Map 
Metabolic pathways hsa01100            Pathway Map 
Terpenoid backbone biosynthesis hsa00900            Pathway Map 
  3D Structure
PDB ID: 2WYA 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -7.843635203 FZR = 3.41834E-12
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -3.168513024 FZR = 1

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
CHLOROTHIAZIDE . 2720  D0M9WM  DGIdb
HYDROCHLOROTHIAZIDE . 3639  D0U4UQ  DGIdb

Protein Sequence Information

MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV
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