Host Protein General Information

  Protein Name
Cyclin-dependent kinase 6
  Gene Name
CDK6
  Host Species
Homo sapiens
  Uniprot Entry Name
CDK6_HUMAN
  Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  EC Number
2.7.11.22
  Subcellular Location
Cytoplasm; Nucleus; Cell projection; ruffle
  External Link
NCBI Gene ID
1021
Uniprot ID
Q00534
Ensembl ID
ENSG00000144677
HGNC ID
1777
  Related KEGG Pathway
Hepatitis C hsa05160            Pathway Map 
Measles hsa05162            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Influenza A hsa05164            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Epstein-Barr virus infection hsa05169            Pathway Map 
Cell cycle hsa04110            Pathway Map 
p53 signaling pathway hsa04115            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
Cellular senescence hsa04218            Pathway Map 
Cushing syndrome hsa04934            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Pancreatic cancer hsa05212            Pathway Map 
Glioma hsa05214            Pathway Map 
Melanoma hsa05218            Pathway Map 
Chronic myeloid leukemia hsa05220            Pathway Map 
Small cell lung cancer hsa05222            Pathway Map 
Non-small cell lung cancer hsa05223            Pathway Map 
Breast cancer hsa05224            Pathway Map 
Hepatocellular carcinoma hsa05225            Pathway Map 
  3D Structure
PDB ID: 1BI7 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -9.804879549 FZR = 9.7942E-20
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -10.33699096 FZR = 6.25E-22

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ABEMACICLIB . 46220502  D05SBO  DGIdb
abemaciclib . 46220502  D05SBO  DrugCentral
APREMILAST . 11561674  D07ESC  DGIdb
AT-7519 . 11338033  D07DTV  DGIdb
AZD-5438 . 16747683  D06WHY  DGIdb
DEXAMETHASONE . 5743  D0IT2G  DGIdb
FULVESTRANT . 104741  D0JO7Y  DGIdb
PALBOCICLIB . 5330286  D00UZR  DGIdb
palbociclib . 5330286  D00UZR  DrugCentral
PHA-793887 . 46191454  D0P1CV  DGIdb
quercetin . 5280343  D0K8KX  DrugCentral
RGB-286638 . 11285001  D03DKV  DGIdb
RIBOCICLIB . 44631912  D08MXP  DGIdb
ribociclib . 44631912  D08MXP  DrugCentral
RIBOCICLIB SUCCINATE . 57334219  D01HVT  DGIdb
RONICICLIB . 45380979  D0NV9O  DGIdb
TRILACICLIB . 68029831  D0AP9E  DGIdb
trilaciclib . 68029831  D0AP9E  DrugCentral
trilaciclib . 68029831  D0AP9E  .
UCN-01 . 72271  D0Z9VY  DGIdb

Protein Sequence Information

MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
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