Host Protein General Information

  Protein Name
Focal adhesion kinase 1
  Gene Name
PTK2
  Host Species
Homo sapiens
  Uniprot Entry Name
FAK1_HUMAN
  Protein Families
Protein kinase superfamily, Tyr protein kinase family, FAK subfamily
  EC Number
2.7.10.2
  Subcellular Location
Cell junction; desmosome
  External Link
NCBI Gene ID
5747
Uniprot ID
Q05397
Ensembl ID
ENSG00000169398
HGNC ID
9611
  Related KEGG Pathway
Chemokine signaling pathway hsa04062            Pathway Map 
Leukocyte transendothelial migration hsa04670            Pathway Map 
Bacterial invasion of epithelial cells hsa05100            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Amoebiasis hsa05146            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
Endocrine resistance hsa01522            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Transcriptional misregulation in cancer hsa05202            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
Chemical carcinogenesis - reactive oxygen species hsa05208            Pathway Map 
Small cell lung cancer hsa05222            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Fluid shear stress and atherosclerosis hsa05418            Pathway Map 
Regulation of actin cytoskeleton hsa04810            Pathway Map 
Focal adhesion hsa04510            Pathway Map 
Axon guidance hsa04360            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
VEGF signaling pathway hsa04370            Pathway Map 
  3D Structure
PDB ID: 1K04 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) A549 Cells (Adenocarcinoma human alveolar basal epithelial cell) . Lung . P-value = 2.32060483430296e-05 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 2.32060483430296e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 0.00241809784187763 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h P = 0.00127761489375071 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h P = 0.000943319181411703 .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ADAVOSERTIB . 24856436  D02KKA  DGIdb
ALISERTIB . 24771867  D0S4JK  DGIdb
bosutinib . 5328940  D0OB0F  DrugCentral
CEP-37440 . 71721648  D0N6NM  DGIdb
chloropyramine . 25295  D0K6RA  DrugCentral
crizotinib . 11626560  D03ZBT  DrugCentral
DEFACTINIB HYDROCHLORIDE . 25117126  D0Y1UO  DGIdb
ENMD-2076 . 16041424  D0S7HM  DGIdb
ENTRECTINIB . 25141092  D0O0LS  DGIdb
entrectinib . 25141092  D0O0LS  DrugCentral
erlotinib . 176870  D07POC  DrugCentral
fedratinib . 16722836  D0G8BM  DrugCentral
GSK-2256098 . 46214930  D0B9MR  DGIdb
HESPERADIN . 135421442  D05WSM  DGIdb
ILORASERTIB . 46207586  D08HOM  DGIdb
LINIFANIB . 11485656  D0M9QZ  DGIdb
lorlatinib . 71731823  D0AF6O  DrugCentral
MASITINIB . 10074640  D0MW0N  DGIdb
MLN-8054 . 11712649  D0A5MC  DGIdb
neratinib . . . DrugCentral
nintedanib . 135423438  D09HNV  DrugCentral
PAZOPANIB . . . DGIdb
PD-0166285 . 5311382  D0H8KG  DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
quercetin . 5280343  D0K8KX  DrugCentral
R-406 . 11213558  D0S6TK  DGIdb
SNS-314 . 24995524  D0OA5G  DGIdb
sunitinib . 5329102  D0R0MW  DrugCentral
VS-4718 . 25073775  D0A6VD  DGIdb

Protein Sequence Information

MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
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