Host Protein General Information

  Protein Name
Protein-tyrosine phosphatase 1D
  Gene Name
PTPN11
  Host Species
Homo sapiens
  Uniprot Entry Name
PTN11_HUMAN
  Protein Families
Protein-tyrosine phosphatase family, Non-receptor class 2 subfamily
  EC Number
3.1.3.48
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
5781
Uniprot ID
Q06124
Ensembl ID
ENSG00000179295
HGNC ID
9644
  Related KEGG Pathway
C-type lectin receptor signaling pathway hsa04625            Pathway Map 
Natural killer cell mediated cytotoxicity hsa04650            Pathway Map 
Leukocyte transendothelial migration hsa04670            Pathway Map 
Epithelial cell signaling in Helicobacter pylori infection hsa05120            Pathway Map 
Pathogenic Escherichia coli infection hsa05130            Pathway Map 
Herpes simplex virus 1 infection hsa05168            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
Chemical carcinogenesis - reactive oxygen species hsa05208            Pathway Map 
PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235            Pathway Map 
Renal cell carcinoma hsa05211            Pathway Map 
Chronic myeloid leukemia hsa05220            Pathway Map 
Axon guidance hsa04360            Pathway Map 
Insulin resistance hsa04931            Pathway Map 
Adipocytokine signaling pathway hsa04920            Pathway Map 
Neurotrophin signaling pathway hsa04722            Pathway Map 
Ras signaling pathway hsa04014            Pathway Map 
Phospholipase D signaling pathway hsa04072            Pathway Map 
JAK-STAT signaling pathway hsa04630            Pathway Map 
  3D Structure
PDB ID: 2SHP 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 0.00155478142010071 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
cefsulodin . 656575  D0XQ0Q  DrugCentral
enoxolone . . . DrugCentral
estramustine phosphate . . . DrugCentral
OLTIPRAZ . 47318  D0W4NM  DGIdb
PLX-4720 . 24180719  D0F5JZ  DGIdb

Protein Sequence Information

MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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