Host Protein General Information

  Protein Name
MAP kinase signal-integrating kinase 2
  Gene Name
MKNK2
  Host Species
Homo sapiens
  Uniprot Entry Name
MKNK2_HUMAN
  Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  EC Number
2.7.11.1
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
2872
Uniprot ID
Q9HBH9
Ensembl ID
ENSG00000099875
HGNC ID
7111
  Related KEGG Pathway
Insulin signaling pathway hsa04910            Pathway Map 
MAPK signaling pathway hsa04010            Pathway Map 
HIF-1 signaling pathway hsa04066            Pathway Map 
  3D Structure
PDB ID: 2AC3 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -7.146031001 FZR = 6.48484E-10
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -4.132895096 FZR = 0.031917603

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
afatinib . 10184653  D05UFG  DrugCentral
ceritinib . 57379345  D04LVK  DrugCentral
CHEMBL225519 . 11715767  D03DZO  DGIdb
CYC-116 . 6420138  D0CY1B  DGIdb
ERLOTINIB . 176870  D07POC  DGIdb
erlotinib . 176870  D07POC  DrugCentral
fedratinib . 16722836  D0G8BM  DrugCentral
GEFITINIB . 123631  D09XZB  DGIdb
gefitinib . 123631  D09XZB  DrugCentral
GSK-269962A . 16095342  D02ZQS  DGIdb
ILORASERTIB . 46207586  D08HOM  DGIdb
LINIFANIB . 11485656  D0M9QZ  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
quizartinib . 24889392  D07KYT  DrugCentral
R-406 . 11213558  D0S6TK  DGIdb
ruxolitinib . 25126798  D04LKS  DrugCentral
SNS-314 . 24995524  D0OA5G  DGIdb
SORAFENIB . 216239  D0W5HK  DGIdb
sorafenib . 216239  D0W5HK  DrugCentral
SP-600125 . 8515  D02PVB  DGIdb
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb
tofacitinib . 9926791  D0EG1I  DrugCentral
TOMIVOSERTIB . 118598754  D07XOV  DGIdb
vandetanib . 3081361  D0G6QF  DrugCentral

Protein Sequence Information

MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
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