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| Strain Information | Strain Name |
Dengue virus 2
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|---|---|---|---|---|---|---|---|---|---|
| Strain Family |
Flaviviridae
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| RNA Binding Site |
3'UTR
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| Virus Information | Virus Name |
Dengue virus 2 (DENV2)
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| Taxonomy ID | 11060 | ||||||||
Full list of proteins interacting with the 3'UTR of this Strain
| Protein Name | Uniprot ID | Host Species | Pro Info | Detection Method | Infection Cell | Cell ID | Cell Originated Tissue | Infection Time | Interaction Score | Fold Change |
|---|---|---|---|---|---|---|---|---|---|---|
| 100 kDa coactivator | Q7KZF4 | Homo sapiens | Pro Info | RNA immunoprecipitation (RIP) and confocal immunofluorescence analyses (IFA) | A549 Cells (Adenocarcinoma human alveolar basal epithelial cell) | . | Lung | . | . | . |
| 60S ribosomal protein L17 | P18621 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| 60S ribosomal protein L22 | P35268 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| 60S ribosomal protein L7a | P62424 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| DNA dC->dU-editing enzyme APOBEC-3C | Q9NRW3 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Elongation factor 1-alpha 1 | P68104 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Enhancer of mRNA-decapping protein 3 | Q96F86 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Heterogeneous nuclear ribonucleoprotein F | P52597 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Heterogeneous nuclear ribonucleoprotein H | P31943 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Heterogeneous nuclear ribonucleoprotein K | P61978 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Peptidyl-prolyl cis-trans isomerase H | O43447 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Phosphorylated adapter RNA export protein | Q9H814 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Poly(rC)-binding protein 2 | Q15366 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Pre-mRNA-processing factor 19 | Q9UMS4 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Probable ATP-dependent RNA helicase DDX6 | P26196 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Protein LSM14 homolog B | Q9BX40 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Ribosome biogenesis protein BRX1 homolog | Q8TDN6 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| RNA-splicing ligase RtcB homolog | Q9Y3I0 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Splicing factor 3B subunit 1 | O75533 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Splicing factor 3B subunit 2 | Q13435 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
| Tudor domain-containing protein 3 | Q9H7E2 | Homo sapiens | Pro Info | Protein-RNA reconstitution and a stringent RNA pulldown assay | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | . | . | . |
Functional Go Enrichment analysis of those proteins interacting with the 3'UTR of this Strain
| GO Term | GO Category | GO ID | Adjusted P-value | Odds Ratio | Combined Score |
|---|---|---|---|---|---|
| RNA Binding | Molecular Function |
GO:0003723
|
7.52E-17 | 80.05455851 | 3269.415851 |
| mRNA Binding | Molecular Function |
GO:0003729
|
6.94E-06 | 28.55507246 | 425.4432618 |
| Cadherin Binding | Molecular Function |
GO:0045296
|
0.004192051 | 14.68832866 | 118.8216014 |
| Large Ribosomal Subunit rRNA Binding | Molecular Function |
GO:0070180
|
0.049027576 | 249.6875 | 1311.244059 |
| Deoxycytidine Deaminase Activity | Molecular Function |
GO:0047844
|
0.049027576 | 166.4416667 | 818.2383072 |
| Ubiquitin Ligase Inhibitor Activity | Molecular Function |
GO:1990948
|
0.049027576 | 166.4416667 | 818.2383072 |
| Ubiquitin-Protein Transferase Inhibitor Activity | Molecular Function |
GO:0055105
|
0.049027576 | 142.6571429 | 682.334006 |
| Vinculin Binding | Molecular Function |
GO:0017166
|
0.05235381 | 110.9444444 | 506.0053047 |
| Cytidine Deaminase Activity | Molecular Function |
GO:0004126
|
0.05235381 | 99.845 | 445.9155629 |
| Ubiquitin-Ubiquitin Ligase Activity | Molecular Function |
GO:0034450
|
0.055629857 | 83.19583333 | 357.7439297 |
| Hydrolase Activity, Acting On Carbon-Nitrogen Bonds, In Cyclic Amidines | Molecular Function |
GO:0016814
|
0.066001528 | 62.384375 | 251.6432337 |
| Deaminase Activity | Molecular Function |
GO:0019239
|
0.069951649 | 52.52631579 | 203.4203292 |
| poly RNA Binding | Molecular Function |
GO:0008266
|
0.069951649 | 47.51904762 | 179.5468678 |
| Cyclosporin A Binding | Molecular Function |
GO:0016018
|
0.069951649 | 45.35681818 | 169.3834835 |
| Poly-Pyrimidine Tract Binding | Molecular Function |
GO:0008187
|
0.070894723 | 41.57291667 | 151.8276652 |
| Ubiquitin Protein Ligase Binding | Molecular Function |
GO:0031625
|
0.083080886 | 7.712776365 | 26.44498482 |
| Transcription Coactivator Binding | Molecular Function |
GO:0001223
|
0.083080886 | 30.22121212 | 101.2132568 |
| Ubiquitin-Like Protein Ligase Binding | Molecular Function |
GO:0044389
|
0.083080886 | 7.22244636 | 23.91453775 |
| RNA Endonuclease Activity | Molecular Function |
GO:0004521
|
0.090638247 | 24.92375 | 78.8924444 |
| Single-Stranded RNA Binding | Molecular Function |
GO:0003727
|
0.090638247 | 23.73452381 | 74.02130556 |
| Intracellular Membrane-Bounded Organelle | Cellular Component |
GO:0043231
|
3.98E-07 | 17.24490983 | 310.469258 |
| Nucleus | Cellular Component |
GO:0005634
|
3.98E-07 | 14.74569351 | 260.7335179 |
| Cytosolic Large Ribosomal Subunit | Cellular Component |
GO:0022625
|
0.000202628 | 67.78911565 | 729.1010167 |
| Large Ribosomal Subunit | Cellular Component |
GO:0015934
|
0.000202628 | 67.78911565 | 729.1010167 |
| Spliceosomal snRNP Complex | Cellular Component |
GO:0097525
|
0.000213898 | 61.49691358 | 644.3743843 |
| Focal Adhesion | Cellular Component |
GO:0005925
|
0.000249302 | 16.03157723 | 161.6939985 |
| Cell-Substrate Junction | Cellular Component |
GO:0030055
|
0.000249302 | 15.6963141 | 156.7829461 |
| P-body | Cellular Component |
GO:0000932
|
0.000412497 | 41.45625 | 387.6750944 |
| U2-type Spliceosomal Complex | Cellular Component |
GO:0005684
|
0.000466611 | 38.10727969 | 347.1716529 |
| U2 snRNP | Cellular Component |
GO:0005686
|
0.001179713 | 91.33180778 | 737.7313505 |
| U12-type Spliceosomal Complex | Cellular Component |
GO:0005689
|
0.001348746 | 80.78137652 | 633.9941282 |
| Nucleolus | Cellular Component |
GO:0005730
|
0.003146489 | 7.838201697 | 53.9752369 |
| Nuclear Lumen | Cellular Component |
GO:0031981
|
0.003146489 | 7.743548387 | 52.92022252 |
| U2-type Precatalytic Spliceosome | Cellular Component |
GO:0071005
|
0.003253448 | 44.64053751 | 300.277644 |
| Precatalytic Spliceosome | Cellular Component |
GO:0071011
|
0.003417381 | 41.95578947 | 277.2613483 |
| Ribosome | Cellular Component |
GO:0005840
|
0.00439645 | 35.5396967 | 223.6141825 |
| Cytoplasmic Stress Granule | Cellular Component |
GO:0010494
|
0.0063834 | 28.314367 | 165.877657 |
| B-WICH Complex | Cellular Component |
GO:0110016
|
0.013266626 | 199.74 | 1012.625496 |
| Intracellular Non-Membrane-Bounded Organelle | Cellular Component |
GO:0043232
|
0.013756584 | 4.934086134 | 24.56871406 |
| U2-type Catalytic Step 1 Spliceosome | Cellular Component |
GO:0071006
|
0.02183537 | 99.845 | 445.9155629 |
| RNA Splicing, Via Transesterification Reactions With Bulged Adenosine As Nucleophile | Biological Process |
GO:0000377
|
6.80E-08 | 57.24277457 | 1232.641708 |
| mRNA Splicing, Via Spliceosome | Biological Process |
GO:0000398
|
7.60E-08 | 48.46813725 | 989.8569007 |
| mRNA Processing | Biological Process |
GO:0006397
|
7.60E-08 | 47.75845411 | 970.6637447 |
| Gene Expression | Biological Process |
GO:0010467
|
5.40E-07 | 34.06574394 | 615.7974446 |
| RNA Processing | Biological Process |
GO:0006396
|
3.36E-05 | 34.76299157 | 477.0488405 |
| RNA Metabolic Process | Biological Process |
GO:0016070
|
0.0001275 | 43.69873557 | 533.3898668 |
| Peptide Biosynthetic Process | Biological Process |
GO:0043043
|
0.000441679 | 30.29029794 | 327.4215932 |
| Macromolecule Biosynthetic Process | Biological Process |
GO:0009059
|
0.000616346 | 26.02694709 | 266.3511649 |
| Spliceosomal Complex Assembly | Biological Process |
GO:0000245
|
0.000616346 | 56.27118644 | 575.3680768 |
| P-body Assembly | Biological Process |
GO:0033962
|
0.000878555 | 233.5672515 | 2280.803907 |
| mRNA Metabolic Process | Biological Process |
GO:0016071
|
0.00119173 | 40.44105691 | 375.3122886 |
| Translation | Biological Process |
GO:0006412
|
0.00119173 | 20.20358056 | 187.446407 |
| Regulation Of RNA Metabolic Process | Biological Process |
GO:0051252
|
0.001331359 | 37.67234848 | 341.9718058 |
| Cytoplasmic Translation | Biological Process |
GO:0002181
|
0.001331359 | 36.83148148 | 331.9597713 |
| Regulation Of RNA Splicing | Biological Process |
GO:0043484
|
0.001634196 | 33.46801347 | 292.4767072 |
| U2-type Prespliceosome Assembly | Biological Process |
GO:1903241
|
0.002506759 | 100.0401003 | 824.9920614 |
| protein-RNA Complex Assembly | Biological Process |
GO:0022618
|
0.00448229 | 22.48526077 | 170.9969429 |
| Regulation Of Viral Genome Replication | Biological Process |
GO:0045069
|
0.018938644 | 32.24939271 | 196.9346887 |
| RNA Splicing | Biological Process |
GO:0008380
|
0.037822255 | 21.80153509 | 116.8749017 |
| Nuclear-Transcribed mRNA Catabolic Process, Deadenylation-Independent Decay | Biological Process |
GO:0031086
|
0.048074064 | 199.74 | 1012.625496 |
Functional KEGG Enrichment analysis of those proteins interacting with the 3'UTR of this Strain
| Pathways | Category | Adjusted P-value | Odds Ratio | Combined Score |
|---|---|---|---|---|
| Spliceosome | KEGG Pathway | 4.92E-06 | 42.74568966 | 628.6741129 |
| Ribosome | KEGG Pathway | 0.003477018 | 21.31612903 | 158.8763492 |
| Coronavirus disease | KEGG Pathway | 0.007024052 | 14.37409025 | 91.19942603 |
| RNA degradation | KEGG Pathway | 0.009244061 | 27.20710868 | 157.3220116 |
| RNA transport | KEGG Pathway | 0.037930157 | 11.32437071 | 46.76792009 |
| Viral carcinogenesis | KEGG Pathway | 0.037930157 | 10.35768526 | 41.06983743 |
| Ferroptosis | KEGG Pathway | 0.072341624 | 24.92375 | 78.8924444 |
| Legionellosis | KEGG Pathway | 0.087304051 | 17.78839286 | 50.58705013 |
| Leishmaniasis | KEGG Pathway | 0.103798712 | 13.09407895 | 33.42897123 |
| Ubiquitin mediated proteolysis | KEGG Pathway | 0.164658838 | 7.136690647 | 14.17490318 |
| Human immunodeficiency virus 1 infection | KEGG Pathway | 0.218841935 | 4.68436019 | 7.525035587 |
| MicroRNAs in cancer | KEGG Pathway | 0.279790937 | 3.182847896 | 4.054033501 |
Virus RNA Sequence Information
|
>U87411.1 Dengue virus type 2 (strain 16681) polyprotein mRNA, complete cds
AGTTGTTAGTCTACGTGGACCGACAAAGACAGATTCTTTGAGGGAGCTAAGCTCAACGTAGTTCTAACAG
TTTTTTAATTAGAGAGCAGATCTCTGATGAATAACCAACGGAAAAAGGCGAAAAACACGCCTTTCAATAT
GCTGAAACGCGAGAGAAACCGCGTGTCGACTGTGCAACAGCTGACAAAGAGATTCTCACTTGGAATGCTG
CAGGGACGAGGACCATTAAAACTGTTCATGGCCCTGGTGGCGTTCCTTCGTTTCCTAACAATCCCACCAA
CAGCAGGGATATTGAAGAGATGGGGAACAATTAAAAAATCAAAAGCTATTAATGTTTTGAGAGGGTTCAG
GAAAGAGATTGGAAGGATGCTGAACATCTTGAATAGGAGACGCAGATCTGCAGGCATGATCATTATGCTG
ATTCCAACAGTGATGGCGTTCCATTTAACCACACGTAACGGAGAACCACACATGATCGTCAGCAGACAAG
AGAAAGGGAAAAGTCTTCTGTTTAAAACAGAGGATGGCGTGAACATGTGTACCCTCATGGCCATGGACCT
TGGTGAATTGTGTGAAGACACAATCACGTACAAGTGTCCCCTTCTCAGGCAGAATGAGCCAGAAGACATA
GACTGTTGGTGCAACTCTACGTCCACGTGGGTAACTTATGGGACGTGTACCACCATGGGAGAACATAGAA
GAGAAAAAAGATCAGTGGCACTCGTTCCACATGTGGGAATGGGACTGGAGACACGAACTGAAACATGGAT
GTCATCAGAAGGGGCCTGGAAACATGTCCAGAGAATTGAAACTTGGATCTTGAGACATCCAGGCTTCACC
ATGATGGCAGCAATCCTGGCATACACCATAGGAACGACACATTTCCAAAGAGCCCTGATTTTCATCTTAC
TGACAGCTGTCACTCCTTCAATGACAATGCGTTGCATAGGAATGTCAAATAGAGACTTTGTGGAAGGGGT
TTCAGGAGGAAGCTGGGTTGACATAGTCTTAGAACATGGAAGCTGTGTGACGACGATGGCAAAAAACAAA
CCAACATTGGATTTTGAACTGATAAAAACAGAAGCCAAACAGCCTGCCACCCTAAGGAAGTACTGTATAG
AGGCAAAGCTAACCAACACAACAACAGAATCTCGCTGCCCAACACAAGGGGAACCCAGCCTAAATGAAGA
GCAGGACAAAAGGTTCGTCTGCAAACACTCCATGGTAGACAGAGGATGGGGAAATGGATGTGGACTATTT
GGAAAGGGAGGCATTGTGACCTGTGCTATGTTCAGATGCAAAAAGAACATGGAAGGAAAAGTTGTGCAAC
CAGAAAACTTGGAATACACCATTGTGATAACACCTCACTCAGGGGAAGAGCATGCAGTCGGAAATGACAC
AGGAAAACATGGCAAGGAAATCAAAATAACACCACAGAGTTCCATCACAGAAGCAGAATTGACAGGTTAT
GGCACTGTCACAATGGAGTGCTCTCCAAGAACGGGCCTCGACTTCAATGAGATGGTGTTGCTGCAGATGG
AAAATAAAGCTTGGCTGGTGCACAGGCAATGGTTCCTAGACCTGCCGTTACCATGGTTGCCCGGAGCGGA
CACACAAGGGTCAAATTGGATACAGAAAGAGACATTGGTCACTTTCAAAAATCCCCATGCGAAGAAACAG
GATGTTGTTGTTTTAGGATCCCAAGAAGGGGCCATGCACACAGCACTTACAGGGGCCACAGAAATCCAAA
TGTCATCAGGAAACTTACTCTTCACAGGACATCTCAAGTGCAGGCTGAGAATGGACAAGCTACAGCTCAA
AGGAATGTCATACTCTATGTGCACAGGAAAGTTTAAAGTTGTGAAGGAAATAGCAGAAACACAACATGGA
ACAATAGTTATCAGAGTGCAATATGAAGGGGACGGCTCTCCATGCAAGATCCCTTTTGAGATAATGGATT
TGGAAAAAAGACATGTCTTAGGTCGCCTGATTACAGTCAACCCAATTGTGACAGAAAAAGATAGCCCAGT
CAACATAGAAGCAGAACCTCCATTCGGAGACAGCTACATCATCATAGGAGTAGAGCCGGGACAACTGAAG
CTCAACTGGTTTAAGAAAGGAAGTTCTATCGGCCAAATGTTTGAGACAACAATGAGGGGGGCGAAGAGAA
TGGCCATTTTAGGTGACACAGCCTGGGATTTTGGATCCTTGGGAGGAGTGTTTACATCTATAGGAAAGGC
TCTCCACCAAGTCTTTGGAGCAATCTATGGAGCTGCCTTCAGTGGGGTTTCATGGACTATGAAAATCCTC
ATAGGAGTCATTATCACATGGATAGGAATGAATTCACGCAGCACCTCACTGTCTGTGACACTAGTATTGG
TGGGAATTGTGACACTGTATTTGGGAGTCATGGTGCAGGCCGATAGTGGTTGCGTTGTGAGCTGGAAAAA
CAAAGAACTGAAATGTGGCAGTGGGATTTTCATCACAGACAACGTGCACACATGGACAGAACAATACAAG
TTCCAACCAGAATCCCCTTCAAAACTAGCTTCAGCTATCCAGAAAGCCCATGAAGAGGGCATTTGTGGAA
TCCGCTCAGTAACAAGACTGGAGAATCTGATGTGGAAACAAATAACACCAGAATTGAATCACATTCTATC
AGAAAATGAGGTGAAGTTAACTATTATGACAGGAGACATCAAAGGAATCATGCAGGCAGGAAAACGATCT
CTGCGGCCTCAGCCCACTGAGCTGAAGTATTCATGGAAAACATGGGGCAAAGCAAAAATGCTCTCTACAG
AGTCTCATAACCAGACCTTTCTCATTGATGGCCCCGAAACAGCAGAATGCCCCAACACAAATAGAGCTTG
GAATTCGTTGGAAGTTGAAGACTATGGCTTTGGAGTATTCACCACCAATATATGGCTAAAATTGAAAGAA
AAACAGGATGTATTCTGCGACTCAAAACTCATGTCAGCGGCCATAAAAGACAACAGAGCCGTCCATGCCG
ATATGGGTTATTGGATAGAAAGTGCACTCAATGACACATGGAAGATAGAGAAAGCCTCTTTCATTGAAGT
TAAAAACTGCCACTGGCCAAAATCACACACCCTCTGGAGCAATGGAGTGCTAGAAAGTGAGATGATAATT
CCAAAGAATCTCGCTGGACCAGTGTCTCAACACAACTATAGACCAGGCTACCATACACAAATAACAGGAC
CATGGCATCTAGGTAAGCTTGAGATGGACTTTGATTTCTGTGATGGAACAACAGTGGTAGTGACTGAGGA
CTGCGGAAATAGAGGACCCTCTTTGAGAACAACCACTGCCTCTGGAAAACTCATAACAGAATGGTGCTGC
CGATCTTGCACATTACCACCGCTAAGATACAGAGGTGAGGATGGGTGCTGGTACGGGATGGAAATCAGAC
CATTGAAGGAGAAAGAAGAGAATTTGGTCAACTCCTTGGTCACAGCTGGACATGGGCAGGTCGACAACTT
TTCACTAGGAGTCTTGGGAATGGCATTGTTCCTGGAGGAAATGCTTAGGACCCGAGTAGGAACGAAACAT
GCAATACTACTAGTTGCAGTTTCTTTTGTGACATTGATCACAGGGAACATGTCCTTTAGAGACCTGGGAA
GAGTGATGGTTATGGTAGGCGCCACTATGACGGATGACATAGGTATGGGCGTGACTTATCTTGCCCTACT
AGCAGCCTTCAAAGTCAGACCAACTTTTGCAGCTGGACTACTCTTGAGAAAGCTGACCTCCAAGGAATTG
ATGATGACTACTATAGGAATTGTACTCCTCTCCCAGAGCACCATACCAGAGACCATTCTTGAGTTGACTG
ATGCGTTAGCCTTAGGCATGATGGTCCTCAAAATGGTGAGAAATATGGAAAAGTATCAATTGGCAGTGAC
TATCATGGCTATCTTGTGCGTCCCAAACGCAGTGATATTACAAAACGCATGGAAAGTGAGTTGCACAATA
TTGGCAGTGGTGTCCGTTTCCCCACTGCTCTTAACATCCTCACAGCAAAAAACAGATTGGATACCATTAG
CATTGACGATCAAAGGTCTCAATCCAACAGCTATTTTTCTAACAACCCTCTCAAGAACCAGCAAGAAAAG
GAGCTGGCCATTAAATGAGGCTATCATGGCAGTCGGGATGGTGAGCATTTTAGCCAGTTCTCTCCTAAAA
AATGATATTCCCATGACAGGACCATTAGTGGCTGGAGGGCTCCTCACTGTGTGCTACGTGCTCACTGGAC
GATCGGCCGATTTGGAACTGGAGAGAGCAGCCGATGTCAAATGGGAAGACCAGGCAGAGATATCAGGAAG
CAGTCCAATCCTGTCAATAACAATATCAGAAGATGGTAGCATGTCGATAAAAAATGAAGAGGAAGAACAA
ACACTGACCATACTCATTAGAACAGGATTGCTGGTGATCTCAGGACTTTTTCCTGTATCAATACCAATCA
CGGCAGCAGCATGGTACCTGTGGGAAGTGAAGAAACAACGGGCCGGAGTATTGTGGGATGTTCCTTCACC
CCCACCCATGGGAAAGGCTGAACTGGAAGATGGAGCCTATAGAATTAAGCAAAAAGGGATTCTTGGATAT
TCCCAGATCGGAGCCGGAGTTTACAAAGAAGGAACATTCCATACAATGTGGCATGTCACACGTGGCGCTG
TTCTAATGCATAAAGGAAAGAGGATTGAACCATCATGGGCGGACGTCAAGAAAGACCTAATATCATATGG
AGGAGGCTGGAAGTTAGAAGGAGAATGGAAGGAAGGAGAAGAAGTCCAGGTATTGGCACTGGAGCCTGGA
AAAAATCCAAGAGCCGTCCAAACGAAACCTGGTCTTTTCAAAACCAACGCCGGAACAATAGGTGCTGTAT
CTCTGGACTTTTCTCCTGGAACGTCAGGATCTCCAATTATCGACAAAAAAGGAAAAGTTGTGGGTCTTTA
TGGTAATGGTGTTGTTACAAGGAGTGGAGCATATGTGAGTGCTATAGCCCAGACTGAAAAAAGCATTGAA
GACAACCCAGAGATCGAAGATGACATTTTCCGAAAGAGAAGACTGACCATCATGGACCTCCACCCAGGAG
CGGGAAAGACGAAGAGATACCTTCCGGCCATAGTCAGAGAAGCTATAAAACGGGGTTTGAGAACATTAAT
CTTGGCCCCCACTAGAGTTGTGGCAGCTGAAATGGAGGAAGCCCTTAGAGGACTTCCAATAAGATACCAG
ACCCCAGCCATCAGAGCTGAGCACACCGGGCGGGAGATTGTGGACCTAATGTGTCATGCCACATTTACCA
TGAGGCTGCTATCACCAGTTAGAGTGCCAAACTACAACCTGATTATCATGGACGAAGCCCATTTCACAGA
CCCAGCAAGTATAGCAGCTAGAGGATACATCTCAACTCGAGTGGAGATGGGTGAGGCAGCTGGGATTTTT
ATGACAGCCACTCCCCCGGGAAGCAGAGACCCATTTCCTCAGAGCAATGCACCAATCATAGATGAAGAAA
GAGAAATCCCTGAACGTTCGTGGAATTCCGGACATGAATGGGTCACGGATTTTAAAGGGAAGACTGTTTG
GTTCGTTCCAAGTATAAAAGCAGGAAATGATATAGCAGCTTGCCTGAGGAAAAATGGAAAGAAAGTGATA
CAACTCAGTAGGAAGACCTTTGATTCTGAGTATGTCAAGACTAGAACCAATGATTGGGACTTCGTGGTTA
CAACTGACATTTCAGAAATGGGTGCCAATTTCAAGGCTGAGAGGGTTATAGACCCCAGACGCTGCATGAA
ACCAGTCATACTAACAGATGGTGAAGAGCGGGTGATTCTGGCAGGACCTATGCCAGTGACCCACTCTAGT
GCAGCACAAAGAAGAGGGAGAATAGGAAGAAATCCAAAAAATGAGAATGACCAGTACATATACATGGGGG
AACCTCTGGAAAATGATGAAGACTGTGCACACTGGAAAGAAGCTAAAATGCTCCTAGATAACATCAACAC
GCCAGAAGGAATCATTCCTAGCATGTTCGAACCAGAGCGTGAAAAGGTGGATGCCATTGATGGCGAATAC
CGCTTGAGAGGAGAAGCAAGGAAAACCTTTGTAGACTTAATGAGAAGAGGAGACCTACCAGTCTGGTTGG
CCTACAGAGTGGCAGCTGAAGGCATCAACTACGCAGACAGAAGGTGGTGTTTTGATGGAGTCAAGAACAA
CCAAATCCTAGAAGAAAACGTGGAAGTTGAAATCTGGACAAAAGAAGGGGAAAGGAAGAAATTGAAACCC
AGATGGTTGGATGCTAGGATCTATTCTGACCCACTGGCGCTAAAAGAATTTAAGGAATTTGCAGCCGGAA
GAAAGTCTCTGACCCTGAACCTAATCACAGAAATGGGTAGGCTCCCAACCTTCATGACTCAGAAGGCAAG
AGACGCACTGGACAACTTAGCAGTGCTGCACACGGCTGAGGCAGGTGGAAGGGCGTACAACCATGCTCTC
AGTGAACTGCCGGAGACCCTGGAGACATTGCTTTTACTGACACTTCTGGCTACAGTCACGGGAGGGATCT
TTTTATTCTTGATGAGCGGAAGGGGCATAGGGAAGATGACCCTGGGAATGTGCTGCATAATCACGGCTAG
CATCCTCCTATGGTACGCACAAATACAGCCACACTGGATAGCAGCTTCAATAATACTGGAGTTTTTTCTC
ATAGTTTTGCTTATTCCAGAACCTGAAAAACAGAGAACACCCCAAGACAACCAACTGACCTACGTTGTCA
TAGCCATCCTCACAGTGGTGGCCGCAACCATGGCAAACGAGATGGGTTTCCTAGAAAAAACGAAGAAAGA
TCTCGGATTGGGAAGCATTGCAACCCAGCAACCCGAGAGCAACATCCTGGACATAGATCTACGTCCTGCA
TCAGCATGGACGCTGTATGCCGTGGCCACAACATTTGTTACACCAATGTTGAGACATAGCATTGAAAATT
CCTCAGTGAATGTGTCCCTAACAGCTATAGCCAACCAAGCCACAGTGTTAATGGGTCTCGGGAAAGGATG
GCCATTGTCAAAGATGGACATCGGAGTTCCCCTTCTCGCCATTGGATGCTACTCACAAGTCAACCCCATA
ACTCTCACAGCAGCTCTTTTCTTATTGGTAGCACATTATGCCATCATAGGGCCAGGACTCCAAGCAAAAG
CAACCAGAGAAGCTCAGAAAAGAGCAGCGGCGGGCATCATGAAAAACCCAACTGTCGATGGAATAACAGT
GATTGACCTAGATCCAATACCTTATGATCCAAAGTTTGAAAAGCAGTTGGGACAAGTAATGCTCCTAGTC
CTCTGCGTGACTCAAGTATTGATGATGAGGACTACATGGGCTCTGTGTGAGGCTTTAACCTTAGCTACCG
GGCCCATCTCCACATTGTGGGAAGGAAATCCAGGGAGGTTTTGGAACACTACCATTGCGGTGTCAATGGC
TAACATTTTTAGAGGGAGTTACTTGGCCGGAGCTGGACTTCTCTTTTCTATTATGAAGAACACAACCAAC
ACAAGAAGGGGAACTGGCAACATAGGAGAGACGCTTGGAGAGAAATGGAAAAGCCGATTGAACGCATTGG
GAAAAAGTGAATTCCAGATCTACAAGAAAAGTGGAATCCAGGAAGTGGATAGAACCTTAGCAAAAGAAGG
CATTAAAAGAGGAGAAACGGACCATCACGCTGTGTCGCGAGGCTCAGCAAAACTGAGATGGTTCGTTGAG
AGAAACATGGTCACACCAGAAGGGAAAGTAGTGGACCTCGGTTGTGGCAGAGGAGGCTGGTCATACTATT
GTGGAGGACTAAAGAATGTAAGAGAAGTCAAAGGCCTAACAAAAGGAGGACCAGGACACGAAGAACCCAT
CCCCATGTCAACATATGGGTGGAATCTAGTGCGTCTTCAAAGTGGAGTTGACGTTTTCTTCATCCCGCCA
GAAAAGTGTGACACATTATTGTGTGACATAGGGGAGTCATCACCAAATCCCACAGTGGAAGCAGGACGAA
CACTCAGAGTCCTTAACTTAGTAGAAAATTGGTTGAACAACAACACTCAATTTTGCATAAAGGTTCTCAA
CCCATATATGCCCTCAGTCATAGAAAAAATGGAAGCACTACAAAGGAAATATGGAGGAGCCTTAGTGAGG
AATCCACTCTCACGAAACTCCACACATGAGATGTACTGGGTATCCAATGCTTCCGGGAACATAGTGTCAT
CAGTGAACATGATTTCAAGGATGTTGATCAACAGATTTACAATGAGATACAAGAAAGCCACTTACGAGCC
GGATGTTGACCTCGGAAGCGGAACCCGTAACATCGGGATTGAAAGTGAGATACCAAACCTAGATATAATT
GGGAAAAGAATAGAAAAAATAAAGCAAGAGCATGAAACATCATGGCACTATGACCAAGACCACCCATACA
AAACGTGGGCATACCATGGTAGCTATGAAACAAAACAGACTGGATCAGCATCATCCATGGTCAACGGAGT
GGTCAGGCTGCTGACAAAACCTTGGGACGTCGTCCCCATGGTGACACAGATGGCAATGACAGACACGACT
CCATTTGGACAACAGCGCGTTTTTAAAGAGAAAGTGGACACGAGAACCCAAGAACCGAAAGAAGGCACGA
AGAAACTAATGAAAATAACAGCAGAGTGGCTTTGGAAAGAATTAGGGAAGAAAAAGACACCCAGGATGTG
CACCAGAGAAGAATTCACAAGAAAGGTGAGAAGCAATGCAGCCTTGGGGGCCATATTCACTGATGAGAAC
AAGTGGAAGTCGGCACGTGAGGCTGTTGAAGATAGTAGGTTTTGGGAGCTGGTTGACAAGGAAAGGAATC
TCCATCTTGAAGGAAAGTGTGAAACATGTGTGTACAACATGATGGGAAAAAGAGAGAAGAAGCTAGGGGA
ATTCGGCAAGGCAAAAGGCAGCAGAGCCATATGGTACATGTGGCTTGGAGCACGCTTCTTAGAGTTTGAA
GCCCTAGGATTCTTAAATGAAGATCACTGGTTCTCCAGAGAGAACTCCCTGAGTGGAGTGGAAGGAGAAG
GGCTGCACAAGCTAGGTTACATTCTAAGAGACGTGAGCAAGAAAGAGGGAGGAGCAATGTATGCCGATGA
CACCGCAGGATGGGATACAAGAATCACACTAGAAGACCTAAAAAATGAAGAAATGGTAACAAACCACATG
GAAGGAGAACACAAGAAACTAGCCGAGGCCATTTTCAAACTAACGTACCAAAACAAGGTGGTGCGTGTGC
AAAGACCAACACCAAGAGGCACAGTAATGGACATCATATCGAGAAGAGACCAAAGAGGTAGTGGACAAGT
TGGCACCTATGGACTCAATACTTTCACCAATATGGAAGCCCAACTAATCAGACAGATGGAGGGAGAAGGA
GTCTTTAAAAGCATTCAGCACCTAACAATCACAGAAGAAATCGCTGTGCAAAACTGGTTAGCAAGAGTGG
GGCGCGAAAGGTTATCAAGAATGGCCATCAGTGGAGATGATTGTGTTGTGAAACCTTTAGATGACAGGTT
CGCAAGCGCTTTAACAGCTCTAAATGACATGGGAAAGATTAGGAAAGACATACAACAATGGGAACCTTCA
AGAGGATGGAATGATTGGACACAAGTGCCCTTCTGTTCACACCATTTCCATGAGTTAATCATGAAAGACG
GTCGCGTACTCGTTGTTCCATGTAGAAACCAAGATGAACTGATTGGCAGAGCCCGAATCTCCCAAGGAGC
AGGGTGGTCTTTGCGGGAGACGGCCTGTTTGGGGAAGTCTTACGCCCAAATGTGGAGCTTGATGTACTTC
CACAGACGCGACCTCAGGCTGGCGGCAAATGCTATTTGCTCGGCAGTACCATCACATTGGGTTCCAACAA
GTCGAACAACCTGGTCCATACATGCTAAACATGAATGGATGACAACGGAAGACATGCTGACAGTCTGGAA
CAGGGTGTGGATTCAAGAAAACCCATGGATGGAAGACAAAACTCCAGTGGAATCATGGGAGGAAATCCCA
TACTTGGGGAAAAGAGAAGACCAATGGTGCGGCTCATTGATTGGGTTAACAAGCAGGGCCACCTGGGCAA
AGAACATCCAAGCAGCAATAAATCAAGTTAGATCCCTTATAGGCAATGAAGAATACACAGATTACATGCC
ATCCATGAAAAGATTCAGAAGAGAAGAGGAAGAAGCAGGAGTTCTGTGGTAGAAAGCAAAACTAACATGA
AACAAGGCTAGAAGTCAGGTCGGATTAAGCCATAGTACGGAAAAAACTATGCTACCTGTGAGCCCCGTCC
AAGGACGTTAAAAGAAGTCAGGCCATCATAAATGCCATAGCTTGAGTAAACTATGCAGCCTGTAGCTCCA
CCTGAGAAGGTGTAAAAAATCCGGGAGGCCACAAACCATGGAAGCTGTACGCATGGCGTAGTGGACTAGC
GGTTAGAGGAGACCCCTCCCTTACAAATCGCAGCAACAATGGGGGCCCAAGGCGAGATGAAGCTGTAGTC
TCGCTGGAAGGACTAGAGGTTAGAGGAGACCCCCCCGAAACAAAAAACAGCATATTGACGCTGGGAAAGA
CCAGAGATCCTGCTGTCTCCTCAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGA
ATCAACAGGTTCT
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