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| Strain Information | Strain Name |
Hepatitis C virus
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|---|---|---|---|---|---|---|---|---|---|
| Strain Family |
Flaviviridae
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| RNA Binding Site |
5'UTR
|
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| Virus Information | Virus Name |
Hepatitis C virus (HCV)
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| Taxonomy ID | 11103 | ||||||||
| GeneBank ID | AJ132997 | ||||||||
Full list of proteins interacting with the 5'UTR of this Strain
| Protein Name | Uniprot ID | Host Species | Pro Info | Detection Method | Infection Cell | Cell ID | Cell Originated Tissue | Infection Time | Interaction Score | Fold Change |
|---|---|---|---|---|---|---|---|---|---|---|
| Actin | P60709 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| ATP-dependent RNA helicase A | Q08211 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| eIF3a | Q14152 | Homo sapiens | Pro Info | Mass spectrometry (MS) | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | 1 h | . | . |
| Elongation factor 1-alpha 1 | P68104 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Glyceraldehyde-3-phosphate dehydrogenase | P04406 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Heat shock 70 kDa protein 1A | P0DMV8 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Heterogeneous nuclear ribonucleoprotein M | P52272 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Heterogeneous nuclear ribonucleoprotein Q | O60506 | Homo sapiens | Pro Info | UV cross-linking (UVX) | HeLa Cells (Human cervical carcinoma cell) | . | Cervix | 3 h | . | . |
| Hsp90 co-chaperone Cdc37-like 1 | Q7L3B6 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| IGF2 mRNA-binding protein 1 | Q9NZI8 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Interleukin enhancer-binding factor 3 | Q12906 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Poly(rC)-binding protein 2 | Q15366 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
| Polypyrimidine tract-binding protein 1 | P26599 | Homo sapiens | Pro Info | Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) | HuH-7 Cells (Human hepatocellular carcinoma cell) | . | Liver | . | . | . |
Functional Go Enrichment analysis of those proteins interacting with the 5'UTR of this Strain
| GO Term | GO Category | GO ID | Adjusted P-value | Odds Ratio | Combined Score |
|---|---|---|---|---|---|
| mRNA Binding | Molecular Function |
GO:0003729
|
6.87E-07 | 61.21428571 | 1117.647328 |
| RNA Binding | Molecular Function |
GO:0003723
|
6.87E-07 | 29.82614123 | 524.1965015 |
| Single-Stranded RNA Binding | Molecular Function |
GO:0003727
|
5.13E-05 | 149.6025 | 1923.434518 |
| Double-Stranded RNA Binding | Molecular Function |
GO:0003725
|
0.000135031 | 96.41129032 | 1118.491382 |
| Disordered Domain Specific Binding | Molecular Function |
GO:0097718
|
0.001049965 | 172.8658009 | 1595.797167 |
| mRNA 5'-UTR Binding | Molecular Function |
GO:0048027
|
0.001049965 | 165 | 1508.888145 |
| DNA Binding | Molecular Function |
GO:0003677
|
0.001092886 | 14.22859691 | 127.3539258 |
| mRNA 3'-UTR Binding | Molecular Function |
GO:0003730
|
0.011263803 | 39.75224775 | 255.5756191 |
| Single-Stranded DNA Binding | Molecular Function |
GO:0003697
|
0.011263803 | 38.47775629 | 244.9676277 |
| Purine Ribonucleoside Triphosphate Binding | Molecular Function |
GO:0035639
|
0.01595975 | 12.37674419 | 71.07265066 |
| 3'-5' RNA Helicase Activity | Molecular Function |
GO:0034458
|
0.01595975 | 416.3125 | 2385.602237 |
| C3HC4-type RING Finger Domain Binding | Molecular Function |
GO:0055131
|
0.01595975 | 416.3125 | 2385.602237 |
| Aspartic-Type Endopeptidase Inhibitor Activity | Molecular Function |
GO:0019828
|
0.017673207 | 333.0333333 | 1847.76671 |
| siRNA Binding | Molecular Function |
GO:0035197
|
0.022954552 | 208.1145833 | 1070.484451 |
| Nucleoside Triphosphate Diphosphatase Activity | Molecular Function |
GO:0047429
|
0.022954552 | 208.1145833 | 1070.484451 |
| N6-methyladenosine-containing RNA Binding | Molecular Function |
GO:1990247
|
0.023903833 | 184.9814815 | 932.0597464 |
| Sequence-Specific mRNA Binding | Molecular Function |
GO:1990825
|
0.024740089 | 166.475 | 822.9948695 |
| DNA Replication Origin Binding | Molecular Function |
GO:0003688
|
0.027597403 | 138.7152778 | 662.6705253 |
| 3'-5' DNA Helicase Activity | Molecular Function |
GO:0043138
|
0.028147624 | 128.0384615 | 602.2149226 |
| RNA Polymerase Binding | Molecular Function |
GO:0070063
|
0.032441133 | 104.015625 | 469.1243344 |
| Nucleus | Cellular Component |
GO:0005634
|
0.000127368 | 19.05953977 | 239.2343152 |
| Intracellular Membrane-Bounded Organelle | Cellular Component |
GO:0043231
|
0.000282584 | 15.78747095 | 174.6395178 |
| Actin Cytoskeleton | Cellular Component |
GO:0015629
|
0.000482081 | 27.05744754 | 271.0293837 |
| Intracellular Non-Membrane-Bounded Organelle | Cellular Component |
GO:0043232
|
0.000482081 | 13.55136369 | 133.2725549 |
| Vesicle | Cellular Component |
GO:0031982
|
0.002754291 | 25.54525862 | 198.6292761 |
| Cytoskeleton | Cellular Component |
GO:0005856
|
0.002754291 | 14.48515406 | 111.3380336 |
| Nucleolus | Cellular Component |
GO:0005730
|
0.005571062 | 11.13718673 | 75.03626837 |
| Nuclear Lumen | Cellular Component |
GO:0031981
|
0.005571062 | 11.00286369 | 73.65588789 |
| Focal Adhesion | Cellular Component |
GO:0005925
|
0.006793241 | 15.31484375 | 96.96263402 |
| Cell-Substrate Junction | Cellular Component |
GO:0030055
|
0.006793241 | 14.99617347 | 94.06741076 |
| Ficolin-1-Rich Granule Lumen | Cellular Component |
GO:1904813
|
0.009161361 | 29.85123967 | 175.4770555 |
| RISC-loading Complex | Cellular Component |
GO:0070578
|
0.013625261 | 277.5138889 | 1497.032601 |
| Ficolin-1-Rich Granule | Cellular Component |
GO:0101002
|
0.017010292 | 19.78521479 | 100.7563304 |
| Cytoplasmic Side Of Lysosomal Membrane | Cellular Component |
GO:0098574
|
0.01894398 | 151.3333333 | 735.0172993 |
| RISC Complex | Cellular Component |
GO:0016442
|
0.01894398 | 138.7152778 | 662.6705253 |
| Platelet Dense Granule Lumen | Cellular Component |
GO:0031089
|
0.01894398 | 138.7152778 | 662.6705253 |
| Endoribonuclease Complex | Cellular Component |
GO:1902555
|
0.023287752 | 104.015625 | 469.1243344 |
| Platelet Dense Granule | Cellular Component |
GO:0042827
|
0.025852042 | 87.57894737 | 380.8381799 |
| Secretory Granule Lumen | Cellular Component |
GO:0034774
|
0.032495633 | 11.39143023 | 46.21400011 |
| Polysomal Ribosome | Cellular Component |
GO:0042788
|
0.032495633 | 61.60493827 | 247.3090958 |
| CRD-mediated mRNA Stabilization | Biological Process |
GO:0070934
|
3.28E-06 | 856.2857143 | 14966.02593 |
| Negative Regulation Of Gene Expression | Biological Process |
GO:0010629
|
3.28E-06 | 51.05714286 | 878.9205213 |
| Negative Regulation Of Nuclear-Transcribed mRNA Catabolic Process, Deadenylation-Dependent Decay | Biological Process |
GO:1900152
|
3.28E-06 | 749.2125 | 12856.30491 |
| Positive Regulation Of Cytoplasmic Translation | Biological Process |
GO:2000767
|
5.42E-06 | 544.8 | 8918.191952 |
| Regulation Of Translation | Biological Process |
GO:0006417
|
6.73E-06 | 62.78553299 | 1000.263828 |
| Negative Regulation Of Amide Metabolic Process | Biological Process |
GO:0034249
|
1.31E-05 | 99.36579276 | 1491.332329 |
| Negative Regulation Of Macromolecule Biosynthetic Process | Biological Process |
GO:0010558
|
1.31E-05 | 94.05673759 | 1391.801199 |
| Regulation Of Nuclear-Transcribed mRNA Catabolic Process, Deadenylation-Dependent Decay | Biological Process |
GO:1900151
|
1.31E-05 | 299.505 | 4429.939501 |
| Regulation Of Cytoplasmic Translation | Biological Process |
GO:2000765
|
1.34E-05 | 285.2285714 | 4180.798233 |
| Negative Regulation Of Translation | Biological Process |
GO:0017148
|
1.49E-05 | 85.79935275 | 1239.285275 |
| Negative Regulation Of Cellular Biosynthetic Process | Biological Process |
GO:0031327
|
3.64E-05 | 66.34586466 | 892.5964919 |
| Negative Regulation Of Protein Metabolic Process | Biological Process |
GO:0051248
|
4.42E-05 | 61.67521368 | 812.4144134 |
| Negative Regulation Of mRNA Catabolic Process | Biological Process |
GO:1902373
|
4.84E-05 | 157.4921053 | 2047.814327 |
| mRNA Stabilization | Biological Process |
GO:0048255
|
9.83E-05 | 119.622 | 1461.756257 |
| Positive Regulation Of Translation | Biological Process |
GO:0045727
|
0.000764139 | 56.80571429 | 572.3397045 |
| RNA Metabolic Process | Biological Process |
GO:0016070
|
0.000764139 | 55.21944444 | 551.8386494 |
| Alternative mRNA Splicing, Via Spliceosome | Biological Process |
GO:0000380
|
0.000764139 | 259.3896104 | 2587.348985 |
| Regulation Of Defense Response To Virus | Biological Process |
GO:0050688
|
0.000919478 | 226.9431818 | 2208.734624 |
| Pyroptosis | Biological Process |
GO:0070269
|
0.00214423 | 139.5874126 | 1232.800775 |
| Defense Response To Fungus | Biological Process |
GO:0050832
|
0.002187108 | 134.4107744 | 1177.526367 |
Functional KEGG Enrichment analysis of those proteins interacting with the 5'UTR of this Strain
| Pathways | Category | Adjusted P-value | Odds Ratio | Combined Score |
|---|---|---|---|---|
| Legionellosis | KEGG Pathway | 0.030501339 | 65.89090909 | 487.7250162 |
| Spliceosome | KEGG Pathway | 0.087629258 | 24.37223587 | 133.8010625 |
| RNA transport | KEGG Pathway | 0.087629258 | 19.56818182 | 99.24116713 |
| Pathogenic Escherichia coli infection | KEGG Pathway | 0.087629258 | 18.45407925 | 91.53904236 |
| Salmonella infection | KEGG Pathway | 0.110002567 | 14.53073243 | 65.53122988 |
| Ferroptosis | KEGG Pathway | 0.151770147 | 41.55625 | 151.1383993 |
| Vibrio cholerae infection | KEGG Pathway | 0.151770147 | 33.90816327 | 116.68479 |
| Viral myocarditis | KEGG Pathway | 0.151770147 | 28.14689266 | 91.81145674 |
| Glycolysis / Gluconeogenesis | KEGG Pathway | 0.151770147 | 25.15277778 | 79.32209211 |
| Adherens junction | KEGG Pathway | 0.151770147 | 23.71071429 | 73.42779054 |
| Gastric acid secretion | KEGG Pathway | 0.151770147 | 22.12444444 | 67.04278374 |
| Leishmaniasis | KEGG Pathway | 0.151770147 | 21.83223684 | 65.87844366 |
| Arrhythmogenic right ventricular cardiomyopathy | KEGG Pathway | 0.151770147 | 21.83223684 | 65.87844366 |
| Bacterial invasion of epithelial cells | KEGG Pathway | 0.151770147 | 21.83223684 | 65.87844366 |
| Antigen processing and presentation | KEGG Pathway | 0.151770147 | 21.54761905 | 64.74800798 |
| Hypertrophic cardiomyopathy | KEGG Pathway | 0.151770147 | 18.63108614 | 53.38475929 |
| Dilated cardiomyopathy | KEGG Pathway | 0.151770147 | 17.44912281 | 48.9030875 |
| Longevity regulating pathway | KEGG Pathway | 0.151770147 | 16.40759076 | 45.01871869 |
| HIF-1 signaling pathway | KEGG Pathway | 0.151770147 | 15.33873457 | 41.09989925 |
| Toxoplasmosis | KEGG Pathway | 0.151770147 | 14.92192192 | 39.59124421 |
Virus RNA Sequence Information
|
>NC_004102.1 Hepatitis C virus genotype 1, complete genome
GCCAGCCCCCTGATGGGGGCGACACTCCACCATGAATCACTCCCCTGTGAGGAACTACTGTCTTCACGCA
GAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTGCAGCCTCCAGGACCCCCCCTCCCGGGAGAGCCA
TAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCAGGACGACCGGGTCCTTTCTTGGATAAACCCG
CTCAATGCCTGGAGATTTGGGCGTGCCCCCGCAAGACTGCTAGCCGAGTAGTGTTGGGTCGCGAAAGGCC
TTGTGGTACTGCCTGATAGGGTGCTTGCGAGTGCCCCGGGAGGTCTCGTAGACCGTGCACCATGAGCACG
AATCCTAAACCTCAAAGAAAAACCAAACGTAACACCAACCGTCGCCCACAGGACGTCAAGTTCCCGGGTG
GCGGTCAGATCGTTGGTGGAGTTTACTTGTTGCCGCGCAGGGGCCCTAGATTGGGTGTGCGCGCGACGAG
GAAGACTTCCGAGCGGTCGCAACCTCGAGGTAGACGTCAGCCTATCCCCAAGGCACGTCGGCCCGAGGGC
AGGACCTGGGCTCAGCCCGGGTACCCTTGGCCCCTCTATGGCAATGAGGGTTGCGGGTGGGCGGGATGGC
TCCTGTCTCCCCGTGGCTCTCGGCCTAGCTGGGGCCCCACAGACCCCCGGCGTAGGTCGCGCAATTTGGG
TAAGGTCATCGATACCCTTACGTGCGGCTTCGCCGACCTCATGGGGTACATACCGCTCGTCGGCGCCCCT
CTTGGAGGCGCTGCCAGGGCCCTGGCGCATGGCGTCCGGGTTCTGGAAGACGGCGTGAACTATGCAACAG
GGAACCTTCCTGGTTGCTCTTTCTCTATCTTCCTTCTGGCCCTGCTCTCTTGCCTGACTGTGCCCGCTTC
AGCCTACCAAGTGCGCAATTCCTCGGGGCTTTACCATGTCACCAATGATTGCCCTAACTCGAGTATTGTG
TACGAGGCGGCCGATGCCATCCTGCACACTCCGGGGTGTGTCCCTTGCGTTCGCGAGGGTAACGCCTCGA
GGTGTTGGGTGGCGGTGACCCCCACGGTGGCCACCAGGGACGGCAAACTCCCCACAACGCAGCTTCGACG
TCATATCGATCTGCTTGTCGGGAGCGCCACCCTCTGCTCGGCCCTCTACGTGGGGGACCTGTGCGGGTCT
GTCTTTCTTGTTGGTCAACTGTTTACCTTCTCTCCCAGGCGCCACTGGACGACGCAAGACTGCAATTGTT
CTATCTATCCCGGCCATATAACGGGTCATCGCATGGCATGGGATATGATGATGAACTGGTCCCCTACGGC
AGCGTTGGTGGTAGCTCAGCTGCTCCGGATCCCACAAGCCATCATGGACATGATCGCTGGTGCTCACTGG
GGAGTCCTGGCGGGCATAGCGTATTTCTCCATGGTGGGGAACTGGGCGAAGGTCCTGGTAGTGCTGCTGC
TATTTGCCGGCGTCGACGCGGAAACCCACGTCACCGGGGGAAGTGCCGGCCGCACCACGGCTGGGCTTGT
TGGTCTCCTTACACCAGGCGCCAAGCAGAACATCCAACTGATCAACACCAACGGCAGTTGGCACATCAAT
AGCACGGCCTTGAACTGCAATGAAAGCCTTAACACCGGCTGGTTAGCAGGGCTCTTCTATCAGCACAAAT
TCAACTCTTCAGGCTGTCCTGAGAGGTTGGCCAGCTGCCGACGCCTTACCGATTTTGCCCAGGGCTGGGG
TCCTATCAGTTATGCCAACGGAAGCGGCCTCGACGAACGCCCCTACTGCTGGCACTACCCTCCAAGACCT
TGTGGCATTGTGCCCGCAAAGAGCGTGTGTGGCCCGGTATATTGCTTCACTCCCAGCCCCGTGGTGGTGG
GAACGACCGACAGGTCGGGCGCGCCTACCTACAGCTGGGGTGCAAATGATACGGATGTCTTCGTCCTTAA
CAACACCAGGCCACCGCTGGGCAATTGGTTCGGTTGTACCTGGATGAACTCAACTGGATTCACCAAAGTG
TGCGGAGCGCCCCCTTGTGTCATCGGAGGGGTGGGCAACAACACCTTGCTCTGCCCCACTGATTGTTTCC
GCAAGCATCCGGAAGCCACATACTCTCGGTGCGGCTCCGGTCCCTGGATTACACCCAGGTGCATGGTCGA
CTACCCGTATAGGCTTTGGCACTATCCTTGTACCATCAATTACACCATATTCAAAGTCAGGATGTACGTG
GGAGGGGTCGAGCACAGGCTGGAAGCGGCCTGCAACTGGACGCGGGGCGAACGCTGTGATCTGGAAGACA
GGGACAGGTCCGAGCTCAGCCCATTGCTGCTGTCCACCACACAGTGGCAGGTCCTTCCGTGTTCTTTCAC
GACCCTGCCAGCCTTGTCCACCGGCCTCATCCACCTCCACCAGAACATTGTGGACGTGCAGTACTTGTAC
GGGGTAGGGTCAAGCATCGCGTCCTGGGCCATTAAGTGGGAGTACGTCGTTCTCCTGTTCCTCCTGCTTG
CAGACGCGCGCGTCTGCTCCTGCTTGTGGATGATGTTACTCATATCCCAAGCGGAGGCGGCTTTGGAGAA
CCTCGTAATACTCAATGCAGCATCCCTGGCCGGGACGCACGGTCTTGTGTCCTTCCTCGTGTTCTTCTGC
TTTGCGTGGTATCTGAAGGGTAGGTGGGTGCCCGGAGCGGTCTACGCCTTCTACGGGATGTGGCCTCTCC
TCCTGCTCCTGCTGGCGTTGCCTCAGCGGGCATACGCACTGGACACGGAGGTGGCCGCGTCGTGTGGCGG
CGTTGTTCTTGTCGGGTTAATGGCGCTGACTCTGTCGCCATATTACAAGCGCTACATCAGCTGGTGCATG
TGGTGGCTTCAGTATTTTCTGACCAGAGTAGAAGCGCAACTGCACGTGTGGGTTCCCCCCCTCAACGTCC
GGGGGGGGCGCGATGCCGTCATCTTACTCATGTGTGTTGTACACCCGACTCTGGTATTTGACATCACCAA
ACTACTCCTGGCCATCTTCGGACCCCTTTGGATTCTTCAAGCCAGTTTGCTTAAAGTCCCCTACTTCGTG
CGCGTTCAAGGCCTTCTCCGGATCTGCGCGCTAGCGCGGAAGATAGCCGGAGGTCATTACGTGCAAATGG
CCATCATCAAGTTAGGGGCGCTTACTGGCACCTATGTGTATAACCATCTCACCCCTCTTCGAGACTGGGC
GCACAACGGCCTGCGAGATCTGGCCGTGGCTGTGGAACCAGTCGTCTTCTCCCGAATGGAGACCAAGCTC
ATCACGTGGGGGGCAGATACCGCCGCGTGCGGTGACATCATCAACGGCTTGCCCGTCTCTGCCCGTAGGG
GCCAGGAGATACTGCTTGGGCCAGCCGACGGAATGGTCTCCAAGGGGTGGAGGTTGCTGGCGCCCATCAC
GGCGTACGCCCAGCAGACGAGAGGCCTCCTAGGGTGTATAATCACCAGCCTGACTGGCCGGGACAAAAAC
CAAGTGGAGGGTGAGGTCCAGATCGTGTCAACTGCTACCCAAACCTTCCTGGCAACGTGCATCAATGGGG
TATGCTGGACTGTCTACCACGGGGCCGGAACGAGGACCATCGCATCACCCAAGGGTCCTGTCATCCAGAT
GTATACCAATGTGGACCAAGACCTTGTGGGCTGGCCCGCTCCTCAAGGTTCCCGCTCATTGACACCCTGC
ACCTGCGGCTCCTCGGACCTTTACCTGGTCACGAGGCACGCCGATGTCATTCCCGTGCGCCGGCGAGGTG
ATAGCAGGGGTAGCCTGCTTTCGCCCCGGCCCATTTCCTACTTGAAAGGCTCCTCGGGGGGTCCGCTGTT
GTGCCCCGCGGGACACGCCGTGGGCCTATTCAGGGCCGCGGTGTGCACCCGTGGAGTGGCTAAGGCGGTG
GACTTTATCCCTGTGGAGAACCTAGAGACAACCATGAGATCCCCGGTGTTCACGGACAACTCCTCTCCAC
CAGCAGTGCCCCAGAGCTTCCAGGTGGCCCACCTGCATGCTCCCACCGGCAGCGGTAAGAGCACCAAGGT
CCCGGCTGCGTACGCAGCCCAGGGCTACAAGGTGTTGGTGCTCAACCCCTCTGTTGCTGCAACGCTGGGC
TTTGGTGCTTACATGTCCAAGGCCCATGGGGTTGATCCTAATATCAGGACCGGGGTGAGAACAATTACCA
CTGGCAGCCCCATCACGTACTCCACCTACGGCAAGTTCCTTGCCGACGGCGGGTGCTCAGGAGGTGCTTA
TGACATAATAATTTGTGACGAGTGCCACTCCACGGATGCCACATCCATCTTGGGCATCGGCACTGTCCTT
GACCAAGCAGAGACTGCGGGGGCGAGACTGGTTGTGCTCGCCACTGCTACCCCTCCGGGCTCCGTCACTG
TGTCCCATCCTAACATCGAGGAGGTTGCTCTGTCCACCACCGGAGAGATCCCTTTTTACGGCAAGGCTAT
CCCCCTCGAGGTGATCAAGGGGGGAAGACATCTCATCTTCTGCCACTCAAAGAAGAAGTGCGACGAGCTC
GCCGCGAAGCTGGTCGCATTGGGCATCAATGCCGTGGCCTACTACCGCGGTCTTGACGTGTCTGTCATCC
CGACCAGCGGCGATGTTGTCGTCGTGTCGACCGATGCTCTCATGACTGGCTTTACCGGCGACTTCGACTC
TGTGATAGACTGCAACACGTGTGTCACTCAGACAGTCGATTTCAGCCTTGACCCTACCTTTACCATTGAG
ACAACCACGCTCCCCCAGGATGCTGTCTCCAGGACTCAACGCCGGGGCAGGACTGGCAGGGGGAAGCCAG
GCATCTACAGATTTGTGGCACCGGGGGAGCGCCCCTCCGGCATGTTCGACTCGTCCGTCCTCTGTGAGTG
CTATGACGCGGGCTGTGCTTGGTATGAGCTCACGCCCGCCGAGACTACAGTTAGGCTACGAGCGTACATG
AACACCCCGGGGCTTCCCGTGTGCCAGGACCATCTTGAATTTTGGGAGGGCGTCTTTACGGGCCTCACTC
ATATAGATGCCCACTTTCTATCCCAGACAAAGCAGAGTGGGGAGAACTTTCCTTACCTGGTAGCGTACCA
AGCCACCGTGTGCGCTAGGGCTCAAGCCCCTCCCCCATCGTGGGACCAGATGTGGAAGTGTTTGATCCGC
CTTAAACCCACCCTCCATGGGCCAACACCCCTGCTATACAGACTGGGCGCTGTTCAGAATGAAGTCACCC
TGACGCACCCAATCACCAAATACATCATGACATGCATGTCGGCCGACCTGGAGGTCGTCACGAGCACCTG
GGTGCTCGTTGGCGGCGTCCTGGCTGCTCTGGCCGCGTATTGCCTGTCAACAGGCTGCGTGGTCATAGTG
GGCAGGATTGTCTTGTCCGGGAAGCCGGCAATTATACCTGACAGGGAGGTTCTCTACCAGGAGTTCGATG
AGATGGAAGAGTGCTCTCAGCACTTACCGTACATCGAGCAAGGGATGATGCTCGCTGAGCAGTTCAAGCA
GAAGGCCCTCGGCCTCCTGCAGACCGCGTCCCGCCAAGCAGAGGTTATCACCCCTGCTGTCCAGACCAAC
TGGCAGAAACTCGAGGTCTTCTGGGCGAAGCACATGTGGAATTTCATCAGTGGGATACAATACTTGGCGG
GCCTGTCAACGCTGCCTGGTAACCCCGCCATTGCTTCATTGATGGCTTTTACAGCTGCCGTCACCAGCCC
ACTAACCACTGGCCAAACCCTCCTCTTCAACATATTGGGGGGGTGGGTGGCTGCCCAGCTCGCCGCCCCC
GGTGCCGCTACCGCCTTTGTGGGCGCTGGCTTAGCTGGCGCCGCCATCGGCAGCGTTGGACTGGGGAAGG
TCCTCGTGGACATTCTTGCAGGGTATGGCGCGGGCGTGGCGGGAGCTCTTGTAGCATTCAAGATCATGAG
CGGTGAGGTCCCCTCCACGGAGGACCTGGTCAATCTGCTGCCCGCCATCCTCTCGCCTGGAGCCCTTGTA
GTCGGTGTGGTCTGCGCAGCAATACTGCGCCGGCACGTTGGCCCGGGCGAGGGGGCAGTGCAATGGATGA
ACCGGCTAATAGCCTTCGCCTCCCGGGGGAACCATGTTTCCCCCACGCACTACGTGCCGGAGAGCGATGC
AGCCGCCCGCGTCACTGCCATACTCAGCAGCCTCACTGTAACCCAGCTCCTGAGGCGACTGCATCAGTGG
ATAAGCTCGGAGTGTACCACTCCATGCTCCGGTTCCTGGCTAAGGGACATCTGGGACTGGATATGCGAGG
TGCTGAGCGACTTTAAGACCTGGCTGAAAGCCAAGCTCATGCCACAACTGCCTGGGATTCCCTTTGTGTC
CTGCCAGCGCGGGTATAGGGGGGTCTGGCGAGGAGACGGCATTATGCACACTCGCTGCCACTGTGGAGCT
GAGATCACTGGACATGTCAAAAACGGGACGATGAGGATCGTCGGTCCTAGGACCTGCAGGAACATGTGGA
GTGGGACGTTCCCCATTAACGCCTACACCACGGGCCCCTGTACTCCCCTTCCTGCGCCGAACTATAAGTT
CGCGCTGTGGAGGGTGTCTGCAGAGGAATACGTGGAGATAAGGCGGGTGGGGGACTTCCACTACGTATCG
GGTATGACTACTGACAATCTTAAATGCCCGTGCCAGATCCCATCGCCCGAATTTTTCACAGAATTGGACG
GGGTGCGCCTACATAGGTTTGCGCCCCCTTGCAAGCCCTTGCTGCGGGAGGAGGTATCATTCAGAGTAGG
ACTCCACGAGTACCCGGTGGGGTCGCAATTACCTTGCGAGCCCGAACCGGACGTAGCCGTGTTGACGTCC
ATGCTCACTGATCCCTCCCATATAACAGCAGAGGCGGCCGGGAGAAGGTTGGCGAGAGGGTCACCCCCTT
CTATGGCCAGCTCCTCGGCCAGCCAGCTGTCCGCTCCATCTCTCAAGGCAACTTGCACCGCCAACCATGA
CTCCCCTGACGCCGAGCTCATAGAGGCTAACCTCCTGTGGAGGCAGGAGATGGGCGGCAACATCACCAGG
GTTGAGTCAGAGAACAAAGTGGTGATTCTGGACTCCTTCGATCCGCTTGTGGCAGAGGAGGATGAGCGGG
AGGTCTCCGTACCCGCAGAAATTCTGCGGAAGTCTCGGAGATTCGCCCGGGCCCTGCCCGTTTGGGCGCG
GCCGGACTACAACCCCCCGCTAGTAGAGACGTGGAAAAAGCCTGACTACGAACCACCTGTGGTCCATGGC
TGCCCGCTACCACCTCCACGGTCCCCTCCTGTGCCTCCGCCTCGGAAAAAGCGTACGGTGGTCCTCACCG
AATCAACCCTATCTACTGCCTTGGCCGAGCTTGCCACCAAAAGTTTTGGCAGCTCCTCAACTTCCGGCAT
TACGGGCGACAATACGACAACATCCTCTGAGCCCGCCCCTTCTGGCTGCCCCCCCGACTCCGACGTTGAG
TCCTATTCTTCCATGCCCCCCCTGGAGGGGGAGCCTGGGGATCCGGATCTCAGCGACGGGTCATGGTCGA
CGGTCAGTAGTGGGGCCGACACGGAAGATGTCGTGTGCTGCTCAATGTCTTATTCCTGGACAGGCGCACT
CGTCACCCCGTGCGCTGCGGAAGAACAAAAACTGCCCATCAACGCACTGAGCAACTCGTTGCTACGCCAT
CACAATCTGGTGTATTCCACCACTTCACGCAGTGCTTGCCAAAGGCAGAAGAAAGTCACATTTGACAGAC
TGCAAGTTCTGGACAGCCATTACCAGGACGTGCTCAAGGAGGTCAAAGCAGCGGCGTCAAAAGTGAAGGC
TAACTTGCTATCCGTAGAGGAAGCTTGCAGCCTGACGCCCCCACATTCAGCCAAATCCAAGTTTGGCTAT
GGGGCAAAAGACGTCCGTTGCCATGCCAGAAAGGCCGTAGCCCACATCAACTCCGTGTGGAAAGACCTTC
TGGAAGACAGTGTAACACCAATAGACACTACCATCATGGCCAAGAACGAGGTTTTCTGCGTTCAGCCTGA
GAAGGGGGGTCGTAAGCCAGCTCGTCTCATCGTGTTCCCCGACCTGGGCGTGCGCGTGTGCGAGAAGATG
GCCCTGTACGACGTGGTTAGCAAGCTCCCCCTGGCCGTGATGGGAAGCTCCTACGGATTCCAATACTCAC
CAGGACAGCGGGTTGAATTCCTCGTGCAAGCGTGGAAGTCCAAGAAGACCCCGATGGGGTTCTCGTATGA
TACCCGCTGTTTTGACTCCACAGTCACTGAGAGCGACATCCGTACGGAGGAGGCAATTTACCAATGTTGT
GACCTGGACCCCCAAGCCCGCGTGGCCATCAAGTCCCTCACTGAGAGGCTTTATGTTGGGGGCCCTCTTA
CCAATTCAAGGGGGGAAAACTGCGGCTACCGCAGGTGCCGCGCGAGCGGCGTACTGACAACTAGCTGTGG
TAACACCCTCACTTGCTACATCAAGGCCCGGGCAGCCTGTCGAGCCGCAGGGCTCCAGGACTGCACCATG
CTCGTGTGTGGCGACGACTTAGTCGTTATCTGTGAAAGTGCGGGGGTCCAGGAGGACGCGGCGAGCCTGA
GAGCCTTCACGGAGGCTATGACCAGGTACTCCGCCCCCCCCGGGGACCCCCCACAACCAGAATACGACTT
GGAGCTTATAACATCATGCTCCTCCAACGTGTCAGTCGCCCACGACGGCGCTGGAAAGAGGGTCTACTAC
CTTACCCGTGACCCTACAACCCCCCTCGCGAGAGCCGCGTGGGAGACAGCAAGACACACTCCAGTCAATT
CCTGGCTAGGCAACATAATCATGTTTGCCCCCACACTGTGGGCGAGGATGATACTGATGACCCATTTCTT
TAGCGTCCTCATAGCCAGGGATCAGCTTGAACAGGCTCTTAACTGTGAGATCTACGGAGCCTGCTACTCC
ATAGAACCACTGGATCTACCTCCAATCATTCAAAGACTCCATGGCCTCAGCGCATTTTCACTCCACAGTT
ACTCTCCAGGTGAAATCAATAGGGTGGCCGCATGCCTCAGAAAACTTGGGGTCCCGCCCTTGCGAGCTTG
GAGACACCGGGCCCGGAGCGTCCGCGCTAGGCTTCTGTCCAGAGGAGGCAGGGCTGCCATATGTGGCAAG
TACCTCTTCAACTGGGCAGTAAGAACAAAGCTCAAACTCACTCCAATAGCGGCCGCTGGCCGGCTGGACT
TGTCCGGTTGGTTCACGGCTGGCTACAGCGGGGGAGACATTTATCACAGCGTGTCTCATGCCCGGCCCCG
CTGGTTCTGGTTTTGCCTACTCCTGCTCGCTGCAGGGGTAGGCATCTACCTCCTCCCCAACCGATGAAGG
TTGGGGTAAACACTCCGGCCTCTTAGGCCATTTCCTGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTCTTTTTTTTTTTTTTTTTCCTTTTTTTTTTTTTTTTTTTTCTTTCCTTCTTT
TTTCCTTTCTTTTCCTTCCTTCTTTAATGGTGGCTCCATCTTAGCCCTAGTCACGGCTAGCTGTGAAAGG
TCCGTGAGCCGCATGACTGCAGAGAGTGCTGATACTGGCCTCTCTGCAGATCATGT
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