Host Protein General Information

  Protein Name
Cyclin-dependent kinase 2
  Gene Name
CDK2
  Host Species
Homo sapiens
  Uniprot Entry Name
CDK2_HUMAN
  Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  EC Number
2.7.11.22
  Subcellular Location
Cytoplasm; cytoskeleton; microtubule organizing
  External Link
NCBI Gene ID
1017
Uniprot ID
P24941
Ensembl ID
ENSG00000120896
HGNC ID
1771
  Related KEGG Pathway
Hepatitis C hsa05160            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Measles hsa05162            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Human T-cell leukemia virus 1 infection hsa05166            Pathway Map 
Epstein-Barr virus infection hsa05169            Pathway Map 
FoxO signaling pathway hsa04068            Pathway Map 
Cell cycle hsa04110            Pathway Map 
Oocyte meiosis hsa04114            Pathway Map 
p53 signaling pathway hsa04115            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
Cellular senescence hsa04218            Pathway Map 
Progesterone-mediated oocyte maturation hsa04914            Pathway Map 
Cushing syndrome hsa04934            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
Prostate cancer hsa05215            Pathway Map 
Small cell lung cancer hsa05222            Pathway Map 
Gastric cancer hsa05226            Pathway Map 
  3D Structure
PDB ID: 1AQ1 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -17.75492823 FZR = 1.98603E-67
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -4.907604894 FZR = 0.000924719
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver . . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ACETAMINOPHEN . 1983  D0U5QK  DGIdb
AG-24322 . 135413565  D0IX4B  DGIdb
ALOISINE . 3641059  D00SEC  DGIdb
ALSTERPAULLONE . 5005498  D0H3EV  DGIdb
ANDROSTANOLONE . 10635  D04DJN  DGIdb
AT-7519 . 11338033  D07DTV  DGIdb
AZAKENPAULLONE . 6538897  D0DR8N  DGIdb
AZD-1080 . 135564570  D0MC0O  DGIdb
AZD-5438 . 16747683  D06WHY  DGIdb
BMS-345541 . 9926054  D00YTQ  DGIdb
BMS-387032 . 3025986  D0S5RC  DGIdb
BOHEMINE . 2422  D07ADR  DGIdb
BX-795 . 10077147  D0RG0Z  DGIdb
CARBOPLATIN . 426756  D0X7HM  DGIdb
ceritinib . 57379345  D04LVK  DrugCentral
CHEMBL210618 . 11624601  D00HVA  DGIdb
CHEMBL225519 . 11715767  D03DZO  DGIdb
CHEMBL259850 . 448014  D0A3MV  DGIdb
CHIR-99021 . 9956119  D0YK9D  DGIdb
CYC-065 . 24983461  D0PL7P  DGIdb
CYC-116 . 6420138  D0CY1B  DGIdb
DEXAMETHASONE . 5743  D0IT2G  DGIdb
DINACICLIB . 46926350  D0D3PX  DGIdb
ERIBULIN . 11354606  D0KK2E  DGIdb
GO-6976 . 3501  D08JPU  DGIdb
GS 6201 . 11270783  D0G4CF  DGIdb
GSK-269962A . 16095342  D02ZQS  DGIdb
INDOLE-3-CARBINOL . 3712  DN62DG  DGIdb
JNJ-7706621 . 5330790  D04NGS  DGIdb
KENPAULLONE . 3820  D00PWQ  DGIdb
lapatinib . 208908  D08CDI  DrugCentral
LAUROGUADINE . . . DGIdb
LOVASTATIN . 53232  D06WTZ  DGIdb
LY-2090314 . 10029385  D0Z1DH  DGIdb
MILCICLIB . 16718576  D0Q9UX  DGIdb
nintedanib . 135423438  D09HNV  DrugCentral
OLOMOUCINE . 4592  D00BPA  DGIdb
PACLITAXEL . . . DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
PHA-793887 . 46191454  D0P1CV  DGIdb
quercetin . 5280343  D0K8KX  DrugCentral
R-406 . 11213558  D0S6TK  DGIdb
RALTITREXED . 135400182  D01KKQ  DGIdb
RESVERATROL . 445154  D0U3EP  DGIdb
RGB-286638 . 11285001  D03DKV  DGIdb
ribociclib . 44631912  D08MXP  DrugCentral
RONICICLIB . 45380979  D0NV9O  DGIdb
SCH-900776 . 46239015  D05FWH  DGIdb
SELICICLIB . 160355  D05ADP  DGIdb
sorafenib . 216239  D0W5HK  DrugCentral
SP-600125 . 8515  D02PVB  DGIdb
SU-9516 . 5289419  D0L3FK  DGIdb
TAE-684 . 16038120  D0R2WK  DGIdb
TRILACICLIB . 68029831  D0AP9E  DGIdb
trilaciclib . 68029831  D0AP9E  DrugCentral
UCN-01 . 72271  D0Z9VY  DGIdb

Protein Sequence Information

MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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