Protein Name
HPK/GCK-like kinase HGK
  Gene Name
MAP4K4
  Host Species
Homo sapiens
  Uniprot Entry Name
M4K4_HUMAN
  Protein Families
Protein kinase superfamily
  EC Number
2.7.11.1
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
9448
Uniprot ID
O95819
Ensembl ID
ENSG00000071054
HGNC ID
6866
  Related KEGG Pathway
MAPK signaling pathway hsa04010            Pathway Map 
  3D Structure

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/Wuhan-Hu-1/2019) 3'UTR RNA Info RNA-protein interaction detection (RaPID) assay & liquid chromatography with tandem mass spectrometry (LC-MS/MS) HEK293T cells . Liver 48 h Prot score = 18 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .
Drug Name DrunkBank ID Pubchem ID TTD ID REF
ADAVOSERTIB . 24856436  D02KKA  DGIdb
ALSTERPAULLONE . 5005498  D0H3EV  DGIdb
ANASTROZOLE . 2187  D0W0BF  DGIdb
AST-487 . 11409972  D0N7AJ  DGIdb
axitinib . 6450551  D01ZRI  DrugCentral
AZD-1152-HQPA . 16007391  D0Q7RE  DGIdb
bosutinib . 5328940  D0OB0F  DrugCentral
CEDIRANIB . 9933475  D09VMI  DGIdb
CYC-116 . 6420138  D0CY1B  DGIdb
dasatinib . 3062316  D0E6XR  DrugCentral
DORAMAPIMOD . 156422  D05CDF  DGIdb
DOVITINIB . 135611162  D07OZR  DGIdb
ENTRECTINIB . 25141092  D0O0LS  DGIdb
EXEMESTANE . 60198  D0D2VS  DGIdb
FASUDIL . 3547  D03KKR  DGIdb
GEFITINIB . 123631  D09XZB  DGIdb
ILORASERTIB . 46207586  D08HOM  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
neratinib . . . DrugCentral
nintedanib . 135423438  D09HNV  DrugCentral
PALBOCICLIB . 5330286  D00UZR  DGIdb
PAZOPANIB . . . DGIdb
pazopanib . . . DrugCentral
PD-0166285 . 5311382  D0H8KG  DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
quizartinib . 24889392  D07KYT  DrugCentral
R-1487 . 11406590  D04YHW  DGIdb
SB-202190 . 5169  D0VC0I  DGIdb
SB-203580 . 176155  D0F8DL  DGIdb
SB-220025 . 5164  D09ICC  DGIdb
SB-242235 . 9863367  D0A9KI  DGIdb
sorafenib . 216239  D0W5HK  DrugCentral
SP-600125 . 8515  D02PVB  DGIdb
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb
TAK-715 . 9952773  D0O6ZO  DGIdb
VANDETANIB . 3081361  D0G6QF  DGIdb
vandetanib . 3081361  D0G6QF  DrugCentral

MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPADLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
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