Host Protein General Information

  Protein Name
Proto-oncogene tyrosine-protein kinase Src
  Gene Name
SRC
  Host Species
Homo sapiens
  Uniprot Entry Name
SRC_HUMAN
  Protein Families
Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
  EC Number
2.7.10.2
  Subcellular Location
Cell membrane
  External Link
NCBI Gene ID
6714
Uniprot ID
P12931
Ensembl ID
ENSG00000197122
HGNC ID
11283
  Related KEGG Pathway
Chemokine signaling pathway hsa04062            Pathway Map 
Platelet activation hsa04611            Pathway Map 
Neutrophil extracellular trap formation hsa04613            Pathway Map 
C-type lectin receptor signaling pathway hsa04625            Pathway Map 
Bacterial invasion of epithelial cells hsa05100            Pathway Map 
Epithelial cell signaling in Helicobacter pylori infection hsa05120            Pathway Map 
Pathogenic Escherichia coli infection hsa05130            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Tuberculosis hsa05152            Pathway Map 
Hepatitis B hsa05161            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Herpes simplex virus 1 infection hsa05168            Pathway Map 
EGFR tyrosine kinase inhibitor resistance hsa01521            Pathway Map 
Endocrine resistance hsa01522            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
Rap1 signaling pathway hsa04015            Pathway Map 
Mitophagy - animal hsa04137            Pathway Map 
Endocytosis hsa04144            Pathway Map 
Axon guidance hsa04360            Pathway Map 
VEGF signaling pathway hsa04370            Pathway Map 
Focal adhesion hsa04510            Pathway Map 
Adherens junction hsa04520            Pathway Map 
Tight junction hsa04530            Pathway Map 
Gap junction hsa04540            Pathway Map 
GABAergic synapse hsa04727            Pathway Map 
Inflammatory mediator regulation of TRP channels hsa04750            Pathway Map 
Regulation of actin cytoskeleton hsa04810            Pathway Map 
GnRH signaling pathway hsa04912            Pathway Map 
Estrogen signaling pathway hsa04915            Pathway Map 
Prolactin signaling pathway hsa04917            Pathway Map 
Thyroid hormone signaling pathway hsa04919            Pathway Map 
Oxytocin signaling pathway hsa04921            Pathway Map 
Relaxin signaling pathway hsa04926            Pathway Map 
Viral carcinogenesis hsa05203            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
Chemical carcinogenesis - receptor activation hsa05207            Pathway Map 
Chemical carcinogenesis - reactive oxygen species hsa05208            Pathway Map 
Bladder cancer hsa05219            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Fluid shear stress and atherosclerosis hsa05418            Pathway Map 
  3D Structure
PDB ID: 1A07 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 5'UTR - 3'UTR RNA Info UV cross-linking (UVX) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver 30 h . .
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info UV cross-linking followed by antisense-mediated affinity purification and mass spectrometry HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver 30 h . .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 7.04342125868393e-05 .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ACALABRUTINIB . 71226662  D09PQZ  DGIdb
adenosine phosphate . 6083  D06ACW  DrugCentral
afatinib . 10184653  D05UFG  DrugCentral
ALISERTIB . 24771867  D0S4JK  DGIdb
ALSTERPAULLONE . 5005498  D0H3EV  DGIdb
ANLOTINIB . 25017411  D0G2CG  DGIdb
apatinib . 45139106  D0SZ6E  DrugCentral
BOSUTINIB . 5328940  D0OB0F  DGIdb
bosutinib . 5328940  D0OB0F  DrugCentral
bosutinib . 5328940  D0OB0F  .
cabozantinib . 25102847  D0IQ6P  DrugCentral
CEDIRANIB . 9933475  D09VMI  DGIdb
CERITINIB . 57379345  D04LVK  DGIdb
ceritinib . 57379345  D04LVK  DrugCentral
CHEMBL219557 . 11341869  D03MNN  DGIdb
CHEMBL230686 . 11562302  D0H1OK  DGIdb
CHEMBL406845 . ?  D06CIJ  DGIdb
CISPLATIN . 5702198  D0U5HU  DGIdb
CLOZAPINE . 135398737  D0Z1RV  DGIdb
CRENOLANIB . 10366136  D0J1GR  DGIdb
CRIZOTINIB . 11626560  D03ZBT  DGIdb
crizotinib . 11626560  D03ZBT  DrugCentral
CYC-116 . 6420138  D0CY1B  DGIdb
dacomitinib . 11511120  D06XXH  DrugCentral
DASATINIB . 3062316  D0E6XR  DGIdb
dasatinib . 3062316  D0E6XR  DrugCentral
dasatinib . 3062316  D0E6XR  .
DORAMAPIMOD . 156422  D05CDF  DGIdb
DORSOMORPHIN . 11524144  D0Y0BK  DGIdb
DOVITINIB . 135611162  D07OZR  DGIdb
DOXORUBICIN . 31703  D07VLY  DGIdb
ENMD-2076 . 16041424  D0S7HM  DGIdb
ENMD-981693 . 16041424  D0S7HM  DGIdb
ENTRECTINIB . 25141092  D0O0LS  DGIdb
erlotinib . 176870  D07POC  DrugCentral
fedratinib . 16722836  D0G8BM  DrugCentral
gefitinib . 123631  D09XZB  DrugCentral
GEMCITABINE . 60750  D03UVS  DGIdb
HESPERADIN . 135421442  D05WSM  DGIdb
IBRUTINIB . 24821094  D09KTS  DGIdb
ibrutinib . 24821094  D09KTS  DrugCentral
ILORASERTIB . 46207586  D08HOM  DGIdb
imatinib . 5291  D0AZ3C  DrugCentral
infigratinib . 53235510  D03LWG  DrugCentral
JNJ-26483327 . . D0U3XL  DGIdb
KENPAULLONE . 3820  D00PWQ  DGIdb
KX2-361 . 11545920  D0RE4L  DGIdb
KX2-391 . 23635314  D02LJW  DGIdb
LAPATINIB . 208908  D08CDI  DGIdb
LINIFANIB . 11485656  D0M9QZ  DGIdb
MASITINIB . 10074640  D0MW0N  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
MLN-8054 . 11712649  D0A5MC  DGIdb
neratinib . . . DrugCentral
niclosamide . 4477  D0J9ZR  DrugCentral
nilotinib . 644241  D00STL  DrugCentral
NINTEDANIB . 135423438  D09HNV  DGIdb
nintedanib . 135423438  D09HNV  DrugCentral
PACLITAXEL . . . DGIdb
pazopanib . . . DrugCentral
PD-0166285 . 5311382  D0H8KG  DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
PONATINIB . 24826799  D0H0EQ  DGIdb
ponatinib . 24826799  D0H0EQ  DrugCentral
quercetin . 5280343  D0K8KX  DrugCentral
R-406 . 11213558  D0S6TK  DGIdb
SARACATINIB . 10302451  D0M0XB  DGIdb
SELUMETINIB . 10127622  D0T5DP  DGIdb
sorafenib . 216239  D0W5HK  DrugCentral
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb
TG100-801 . 11973736  D0GP9Q  DGIdb
tirbanibulin . 23635314  D02LJW  DrugCentral
TOZASERTIB . 5494449  D02XNW  DGIdb
trabectedin . 108150  D03RTK  DrugCentral
TRAMETINIB . 11707110  D04XVN  DGIdb
VANDETANIB . 3081361  D0G6QF  DGIdb
vandetanib . 3081361  D0G6QF  DrugCentral
XL-228 . 59757974  D03ZXZ  DGIdb

Protein Sequence Information

MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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