Host Protein General Information

  Protein Name
Serine/threonine-protein kinase mTOR
  Gene Name
MTOR
  Host Species
Homo sapiens
  Uniprot Entry Name
MTOR_HUMAN
  Protein Families
PI3/PI4-kinase family
  EC Number
2.7.11.1
  Subcellular Location
Endoplasmic reticulum membrane
  External Link
NCBI Gene ID
2475
Uniprot ID
P42345
Ensembl ID
ENSG00000089280
HGNC ID
3942
  Related KEGG Pathway
Neutrophil extracellular trap formation hsa04613            Pathway Map 
Th17 cell differentiation hsa04659            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Human papillomavirus infection hsa05165            Pathway Map 
Kaposi sarcoma-associated herpesvirus infection hsa05167            Pathway Map 
Herpes simplex virus 1 infection hsa05168            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
EGFR tyrosine kinase inhibitor resistance hsa01521            Pathway Map 
Endocrine resistance hsa01522            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
HIF-1 signaling pathway hsa04066            Pathway Map 
Phospholipase D signaling pathway hsa04072            Pathway Map 
Autophagy - other hsa04136            Pathway Map 
Autophagy - animal hsa04140            Pathway Map 
mTOR signaling pathway hsa04150            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
AMPK signaling pathway hsa04152            Pathway Map 
Longevity regulating pathway hsa04211            Pathway Map 
Longevity regulating pathway - multiple species hsa04213            Pathway Map 
Cellular senescence hsa04218            Pathway Map 
Apelin signaling pathway hsa04371            Pathway Map 
JAK-STAT signaling pathway hsa04630            Pathway Map 
Thermogenesis hsa04714            Pathway Map 
Insulin signaling pathway hsa04910            Pathway Map 
Thyroid hormone signaling pathway hsa04919            Pathway Map 
Adipocytokine signaling pathway hsa04920            Pathway Map 
Type II diabetes mellitus hsa04930            Pathway Map 
Insulin resistance hsa04931            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
Alzheimer disease hsa05010            Pathway Map 
Amyotrophic lateral sclerosis hsa05014            Pathway Map 
Huntington disease hsa05016            Pathway Map 
Spinocerebellar ataxia hsa05017            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Proteoglycans in cancer hsa05205            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Chemical carcinogenesis - receptor activation hsa05207            Pathway Map 
Colorectal cancer hsa05210            Pathway Map 
Pancreatic cancer hsa05212            Pathway Map 
Glioma hsa05214            Pathway Map 
Prostate cancer hsa05215            Pathway Map 
Acute myeloid leukemia hsa05221            Pathway Map 
Breast cancer hsa05224            Pathway Map 
Hepatocellular carcinoma hsa05225            Pathway Map 
Gastric cancer hsa05226            Pathway Map 
Central carbon metabolism in cancer hsa05230            Pathway Map 
Choline metabolism in cancer hsa05231            Pathway Map 
PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05235            Pathway Map 
Diabetic cardiomyopathy hsa05415            Pathway Map 
  3D Structure
PDB ID: 1AUE 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -16.0869972 FZR = 3.8272E-55
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -5.686074196 FZR = 1.41E-05
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h P = 0.0100350909099628 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 0.00526149940547896 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ALPELISIB . 56649450  D0W7HE  DGIdb
AMIODARONE . 2157  D0L5WM  DGIdb
AMSACRINE . 2179  D0G9YH  DGIdb
APITOLISIB . 25254071  D0O6VZ  DGIdb
AZD-2014 . 25262792  D0Z2UQ  DGIdb
AZD-8055 . 25262965  D0K1VK  DGIdb
BGT-226 . 11978790  D0X7IN  DGIdb
BGT-226 . 11978790  D0X7IN  DGIdb
BIMIRALISIB . 58507717  D0TU7B  DGIdb
BUTACLAMOL . 37459  D0O7DA  DGIdb
CAFFEIC ACID PHENETHYL ESTER . 5281787  D06YGF  DGIdb
CAMPTOTHECIN . 24360  D09YDM  DGIdb
CANERTINIB . 156414  D0YB3W  DGIdb
CANTHARIDIC_ACID . 2544  D0M0TM  DGIdb
CAPIVASERTIB . 25227436  D01ZAQ  DGIdb
CATECHOL . 289  D07QJJ  DGIdb
CC-115 . 58298318  D0O1IM  DGIdb
CC-223 . 58298316  D05EXN  DGIdb
CGS-15943 . 2690  D0Q6WX  DGIdb
CHEMBL24983 . 1609  D0F3CA  DGIdb
CHEMBL429095 . 262093  D0J1KH  DGIdb
CHEMBL445102 . 133633  D0M3PV  DGIdb
CHEMBL568150 . 5289247  D08NQM  DGIdb
COPANLISIB . 135565596  D0S5LD  DGIdb
copanlisib . 135565596  D0S5LD  DrugCentral
dasatinib . 3062316  D0E6XR  DrugCentral
DEQUALINIUM . 2993  D0I2FI  DGIdb
DISULFIRAM . 3117  D0X5SD  DGIdb
DOXAZOSIN . 3157  D03MIR  DGIdb
EBASTINE . . . DGIdb
EMETINE . 10219  D07DJQ  DGIdb
EPINEPHRINE . 5816  D04PHC  DGIdb
EVEROLIMUS . 6442177  D0K3QS  DGIdb
everolimus . 6442177  D0K3QS  DrugCentral
FENRETINIDE . 5288209  D08JAC  DGIdb
GEDATOLISIB . 44516953  D0D8JB  DGIdb
GLASDEGIB . 25166913  D0S5LO  DGIdb
GOSSYPOL . 3503  D0Z0HH  DGIdb
GR-127935 . 107780  D06DZI  DGIdb
HALOPERIDOL . 3559  D0D1AL  DGIdb
IDARUBICIN . 42890  D01XDL  DGIdb
IFENPRODIL . 3689  D0I0DL  DGIdb
INFIGRATINIB . 53235510  D03LWG  DGIdb
ISOPROTERENOL . 3779  D0I8FI  DGIdb
LESTAURTINIB . 126565  D0V9WF  DGIdb
LOPERAMIDE . 3955  D0CS2F  DGIdb
LY-294002 . 3973  D09SFV  DGIdb
MAPROTILINE . 4011  D03KQF  DGIdb
ME-344 . 68026984  D03IXK  DGIdb
METFORMIN . 4091  D0D7LA  DGIdb
MIBEFRADIL . 60663  D0W8XT  DGIdb
MIFEPRISTONE . 55245  D0Z4EI  DGIdb
NICARDIPINE . 4474  D0T0KA  DGIdb
NICLOSAMIDE . 4477  D0J9ZR  DGIdb
OLEOYL DOPAMINE . 5282106  D0M4IF  DGIdb
OMIPALISIB . 25167777  D03EZE  DGIdb
OSI-027 . 135398516  D0H7XL  DGIdb
PALOMID-529 . 11998575  DP17AI  DGIdb
PAROXETINE . 43815  D06GDY  DGIdb
PAZOPANIB . . . DGIdb
PENTAMIDINE ISETHIONATE . 4735  D05EAM  DGIdb
PERPHENAZINE . 4748  D02HED  DGIdb
PF-04691502 . 25033539  D0N5JZ  DGIdb
PI-103 . 9884685  D0W8XH  DGIdb
PIMECROLIMUS . 6509979  D0Z4UN  DGIdb
PIMOZIDE . 16362  D00KHM  DGIdb
PROPAFENONE . 4932  D0J2KV  DGIdb
PYRROLIDINE DITHIOCARBAMATE . 65351  D0B0IJ  DGIdb
QUINACRINE . 237  D0O2DQ  DGIdb
RIDAFOROLIMUS . 11520894  D0O3CV  DGIdb
ridaforolimus . 11520894  D0O3CV  DrugCentral
RITANSERIN . 5074  D0K8NW  DGIdb
ROTENONE . 6758  D0F7CS  DGIdb
SALIRASIB . 5469318  D00KTV  DGIdb
SAPANISERTIB . 45375953  D03DPZ  DGIdb
SF-1126 . 66577114  D03NJY  DGIdb
SIROLIMUS . 5284616  D03LJR  DGIdb
sirolimus . 5284616  D03LJR  DrugCentral
SU-9516 . 5289419  D0L3FK  DGIdb
tacrolimus . 445643  D06OMK  DrugCentral
TANESPIMYCIN . 6505803  D0SC2J  DGIdb
TEMSIROLIMUS . 6918289  D0ES1Q  DGIdb
temsirolimus . 6918289  D0ES1Q  DrugCentral
TERFENADINE . 5405  D08SOF  DGIdb
TG100-115 . 10427712  D0C3ZR  DGIdb
THAPSIGARGIN . 446378  D02KGR  DGIdb
TRIFLUPERIDOL . 5567  D0I8FV  DGIdb
VANDETANIB . 3081361  D0G6QF  DGIdb
VANOXERINE . 3455  D0N2HF  DGIdb
VISTUSERTIB . 25262792  D0Z2UQ  DGIdb
VS-5584 . 46912230  D0U3DP  DGIdb
WORTMANNIN . 312145  D0P1JI  DGIdb
ZOTAROLIMUS . 9876378  D0V7WS  DGIdb
zotarolimus . 9876378  D0V7WS  DrugCentral

Protein Sequence Information

MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW
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