Host Protein General Information

  Protein Name
Crk-like protein
  Gene Name
CRKL
  Host Species
Homo sapiens
  Uniprot Entry Name
CRKL_HUMAN
  Protein Families
CRK family
  External Link
NCBI Gene ID
1399
Uniprot ID
P46109
Ensembl ID
ENSG00000099942
HGNC ID
2363
  Related KEGG Pathway
Chemokine signaling pathway hsa04062            Pathway Map 
Fc gamma R-mediated phagocytosis hsa04666            Pathway Map 
Bacterial invasion of epithelial cells hsa05100            Pathway Map 
Shigellosis hsa05131            Pathway Map 
Yersinia infection hsa05135            Pathway Map 
Human cytomegalovirus infection hsa05163            Pathway Map 
Human immunodeficiency virus 1 infection hsa05170            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
MicroRNAs in cancer hsa05206            Pathway Map 
Renal cell carcinoma hsa05211            Pathway Map 
Chronic myeloid leukemia hsa05220            Pathway Map 
Regulation of actin cytoskeleton hsa04810            Pathway Map 
Focal adhesion hsa04510            Pathway Map 
Insulin signaling pathway hsa04910            Pathway Map 
Growth hormone synthesis, secretion and action hsa04935            Pathway Map 
Neurotrophin signaling pathway hsa04722            Pathway Map 
MAPK signaling pathway hsa04010            Pathway Map 
ErbB signaling pathway hsa04012            Pathway Map 
Rap1 signaling pathway hsa04015            Pathway Map 
  3D Structure
PDB ID: 2BZX 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 1.975542459 FZR = 1
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 5.398537558 FZR = 7.16E-05
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver . . .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/France/IDF-220-95/2020) Not Specified Virus Region RNA Info ChIRP-M/S HEK 293T cells stably expressing the human ACE2 receptor (293T-ACE2) . Embryonic kidneys 48 h SAINT score >= 0.79 .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
DASATINIB . 3062316  D0E6XR  DGIdb
GEFITINIB . 123631  D09XZB  DGIdb

Protein Sequence Information

MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPDENE
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