Host Protein General Information

  Protein Name
Ribosomal protein S6 kinase alpha-3
  Gene Name
RPS6KA3
  Host Species
Homo sapiens
  Uniprot Entry Name
KS6A3_HUMAN
  Protein Families
Protein kinase superfamily
  EC Number
2.7.11.1
  Subcellular Location
Nucleus
  External Link
NCBI Gene ID
6197
Uniprot ID
P51812
Ensembl ID
ENSG00000177189
HGNC ID
10432
  Related KEGG Pathway
Yersinia infection hsa05135            Pathway Map 
Chemical carcinogenesis - receptor activation hsa05207            Pathway Map 
Oocyte meiosis hsa04114            Pathway Map 
Insulin resistance hsa04931            Pathway Map 
Progesterone-mediated oocyte maturation hsa04914            Pathway Map 
Thermogenesis hsa04714            Pathway Map 
Long-term potentiation hsa04720            Pathway Map 
Neurotrophin signaling pathway hsa04722            Pathway Map 
MAPK signaling pathway hsa04010            Pathway Map 
mTOR signaling pathway hsa04150            Pathway Map 
  3D Structure
PDB ID: 4D9T 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5.1 Cells (Human hepatocellular carcinoma cell) . Liver 48 h . .
Zika virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5.1 Cells (Human hepatocellular carcinoma cell) . Liver 48 h . .
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 10.11893138 FZR = 4.24396E-21
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 5.860166733 FZR = 5.15E-06
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/Not Specified Virus Strain) N region RNA Info RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) Huh7 cell line . Liver . P value < 0.05 .
Dengue virus 2 (strain 16681) 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5.1 Cells (Human hepatocellular carcinoma cell) . Liver 48 h Saint score = 1 MIST = 1.878
Dengue virus 2 (strain 16681) 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5.1 Cells (Human hepatocellular carcinoma cell) . Liver 48 h Saint score = 1 MIST = 0.000

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ALISERTIB . 24771867  D0S4JK  DGIdb
bosutinib . 5328940  D0OB0F  DrugCentral
CHEMBL225519 . 11715767  D03DZO  DGIdb
CHEMBL573107 . 25023738  D02VBF  DGIdb
CYC-116 . 6420138  D0CY1B  DGIdb
DOVITINIB . 135611162  D07OZR  DGIdb
ENTRECTINIB . 25141092  D0O0LS  DGIdb
FASUDIL . 3547  D03KKR  DGIdb
fedratinib . 16722836  D0G8BM  DrugCentral
GO-6976 . 3501  D08JPU  DGIdb
GS 6201 . 11270783  D0G4CF  DGIdb
GSK-269962A . 16095342  D02ZQS  DGIdb
HESPERADIN . 135421442  D05WSM  DGIdb
ILORASERTIB . 46207586  D08HOM  DGIdb
JNJ-7706621 . 5330790  D04NGS  DGIdb
LAUROGUADINE . . . DGIdb
LY-2090314 . 10029385  D0Z1DH  DGIdb
midostaurin . 9829523  D07NVU  DrugCentral
nintedanib . 135423438  D09HNV  DrugCentral
PALBOCICLIB . 5330286  D00UZR  DGIdb
PD-0166285 . 5311382  D0H8KG  DGIdb
PF-00562271 . 11713159  D01SJT  DGIdb
ruboxistaurin . 153999  D0W3LI  DrugCentral
SP-600125 . 8515  D02PVB  DGIdb
sunitinib . 5329102  D0R0MW  DrugCentral
TAE-684 . 16038120  D0R2WK  DGIdb
UREA . 1176  D02XBW  DGIdb

Protein Sequence Information

MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL
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