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Full list of proteins interacting with the 5'UTR - 3'UTR of this Strain
| Protein Name | Uniprot ID | Host Species | Pro Info | Detection Method | Infection Cell | Cell ID | Cell Originated Tissue | Infection Time | Interaction Score | Fold Change |
|---|---|---|---|---|---|---|---|---|---|---|
| Interleukin enhancer-binding factor 2 | Q12905 | Homo sapiens | Pro Info | RNA annealing/strand displacement assay | B95a Cells (Marmoset lymphoblastoid cell line) | . | . | . | . | . |
| Interleukin enhancer-binding factor 3 | Q12906 | Homo sapiens | Pro Info | RNA annealing/strand displacement assay | B95a Cells (Marmoset lymphoblastoid cell line) | . | . | . | . | . |
Functional Go Enrichment analysis of those proteins interacting with the 5'UTR - 3'UTR of this Strain
| GO Term | GO Category | GO ID | Adjusted P-value | Odds Ratio | Combined Score |
|---|---|---|---|---|---|
| Double-Stranded RNA Binding | Molecular Function |
GO:0003725
|
6.24E-05 | 39870 | 457457.1177 |
| DNA Binding | Molecular Function |
GO:0003677
|
0.004597389 | 38308 | 242378.095 |
| mRNA 3'-UTR AU-rich Region Binding | Molecular Function |
GO:0035925
|
0.004597389 | 908 | 5516.475891 |
| Single-Stranded RNA Binding | Molecular Function |
GO:0003727
|
0.005968748 | 475.1428571 | 2589.626019 |
| RNA Binding | Molecular Function |
GO:0003723
|
0.005968748 | 37178 | 197174.9945 |
| mRNA 3'-UTR Binding | Molecular Function |
GO:0003730
|
0.009278511 | 216.3695652 | 1012.621293 |
| Nucleolus | Cellular Component |
GO:0005730
|
0.012912311 | 38458 | 250471.8176 |
| Nuclear Lumen | Cellular Component |
GO:0031981
|
0.012912311 | 38440 | 249461.7701 |
| Intracellular Non-Membrane-Bounded Organelle | Cellular Component |
GO:0043232
|
0.02021413 | 37610 | 211969.0006 |
| Tertiary Granule Lumen | Cellular Component |
GO:1904724
|
0.02070863 | 383.5769231 | 2010.465718 |
| Specific Granule Lumen | Cellular Component |
GO:0035580
|
0.02070863 | 332.3 | 1695.055721 |
| Ficolin-1-Rich Granule Lumen | Cellular Component |
GO:1904813
|
0.030476576 | 162.9180328 | 717.0381374 |
| Adherens Junction | Cellular Component |
GO:0005912
|
0.030476576 | 133.2147651 | 559.9610448 |
| Specific Granule | Cellular Component |
GO:0042581
|
0.030476576 | 125.5696203 | 520.5366233 |
| Tertiary Granule | Cellular Component |
GO:0070820
|
0.030476576 | 123.2111801 | 508.4661293 |
| Ficolin-1-Rich Granule | Cellular Component |
GO:0101002
|
0.031136644 | 108.2786885 | 433.1145534 |
| Cell-Cell Junction | Cellular Component |
GO:0005911
|
0.042412766 | 66.10738255 | 232.5248644 |
| Secretory Granule Lumen | Cellular Component |
GO:0034774
|
0.042412766 | 62.48571429 | 216.3574534 |
| Actin Cytoskeleton | Cellular Component |
GO:0015629
|
0.042412766 | 60.34355828 | 206.8921049 |
| Nucleus | Cellular Component |
GO:0005634
|
0.061107723 | 31026 | 92745.18545 |
| Cytoskeleton | Cellular Component |
GO:0005856
|
0.066871432 | 32.44147157 | 91.81411946 |
| Intracellular Membrane-Bounded Organelle | Cellular Component |
GO:0043231
|
0.071125597 | 29650 | 80171.60186 |
| Intracellular Organelle Lumen | Cellular Component |
GO:0070013
|
0.083769929 | 22.38947368 | 55.51875641 |
| Positive Regulation Of Nucleic Acid-Templated Transcription | Biological Process |
GO:1903508
|
0.012995826 | 38886 | 278564.3733 |
| Protein Localization To Synapse | Biological Process |
GO:0035418
|
0.012995826 | 1665.5 | 11068.4336 |
| Protein Localization To Cell Junction | Biological Process |
GO:1902414
|
0.015324629 | 908 | 5516.475891 |
| Positive Regulation Of DNA-templated Transcription | Biological Process |
GO:0045893
|
0.01911104 | 37514 | 208471.9933 |
| Negative Regulation Of Viral Genome Replication | Biological Process |
GO:0045071
|
0.01911104 | 383.5769231 | 2010.465718 |
| Negative Regulation Of Viral Process | Biological Process |
GO:0048525
|
0.01911104 | 332.3 | 1695.055721 |
| Regulation Of Viral Genome Replication | Biological Process |
GO:0045069
|
0.01911104 | 302 | 1512.207996 |
| Regulation Of DNA-templated Transcription | Biological Process |
GO:0006355
|
0.019402795 | 36156 | 169398.5547 |
| Negative Regulation Of Amide Metabolic Process | Biological Process |
GO:0034249
|
0.019402795 | 216.3695652 | 1012.621293 |
| Negative Regulation Of Macromolecule Biosynthetic Process | Biological Process |
GO:0010558
|
0.019402795 | 205.1649485 | 949.4646646 |
| Negative Regulation Of Translation | Biological Process |
GO:0017148
|
0.019402795 | 187.6603774 | 852.0109803 |
| Negative Regulation Of Cellular Biosynthetic Process | Biological Process |
GO:0031327
|
0.022532639 | 146.0441176 | 627.0804859 |
| Negative Regulation Of Protein Metabolic Process | Biological Process |
GO:0051248
|
0.022532639 | 135.9726027 | 574.2902551 |
| Regulation Of Translation | Biological Process |
GO:0006417
|
0.028711914 | 98.49253731 | 384.8219713 |
| Negative Regulation Of Gene Expression | Biological Process |
GO:0010629
|
0.044424525 | 58.69552239 | 199.6613695 |
| Phosphorylation | Biological Process |
GO:0016310
|
0.053036534 | 45.72429907 | 144.4726305 |
| Negative Regulation Of Nucleic Acid-Templated Transcription | Biological Process |
GO:1903507
|
0.053036534 | 42.95164835 | 133.1197518 |
| Protein Phosphorylation | Biological Process |
GO:0006468
|
0.054862212 | 39.0761523 | 117.5524371 |
| Protein Modification Process | Biological Process |
GO:0036211
|
0.073513316 | 27.16619718 | 72.30506178 |
| Negative Regulation Of DNA-templated Transcription | Biological Process |
GO:0045892
|
0.099875573 | 18.52929688 | 42.68835262 |
Full list of Host ncRNAs interacting with the Virus RNA
| HncRNA | Host Species | HncRNA Detail | PMID | Source | Target Gene | Target Gene ID | Target Gene Source | PMID | Source |
|---|---|---|---|---|---|---|---|---|---|
| hsa-miR-122-5p | Homo sapiens | HncRNA Info | 21185047 | ViRBase | ZNF395 | . | miRSponge | 23221562 | miRSponge |
| hsa-miR-196a-1-3p | Homo sapiens | HncRNA Info | 20127796 | ViRBase | . | . | . | . | . |
| hsa-miR-196a-3p | Homo sapiens | HncRNA Info | 20127796 | ViRBase | FGF2 | . | miRTarBase | 28317323 | miRTarBase |
| hsa-miR-196a-5p | Homo sapiens | HncRNA Info | 20127796 | ViRBase | ZNRD2 | . | miRTarBase | 27678369 | miRTarBase |
| hsa-miR-196b-3p | Homo sapiens | HncRNA Info | 20127796 | ViRBase | PSMB1 | . | StarBase | . | StarBase |
| hsa-miR-196b-5p | Homo sapiens | HncRNA Info | 20127796 | ViRBase | TGFBR2 | . | miRTarBase | 26940097 | miRTarBase |
| hsa-miR-199a-3p | Homo sapiens | HncRNA Info | 19144437 | ViRBase | ZHX1 | . | miRTarBase | 25448600 | miRTarBase |
Host ncRNA GO Enrichment
| GO Term | GO Category | GO ID | Adjusted P-value | Odds Ratio | Combined Score |
|---|---|---|---|---|---|
| Activin Receptor Activity | GO Molecular Function |
GO:0017002
|
0.022067627 | 475.8571429 | 2797.6605 |
| Type I Transforming Growth Factor Beta Receptor Binding | GO Molecular Function |
GO:0034713
|
0.022067627 | 416.3541667 | 2398.853181 |
| Transforming Growth Factor Beta Receptor Activity | GO Molecular Function |
GO:0005024
|
0.022067627 | 370.0740741 | 2093.271349 |
| Transmembrane Receptor Protein Serine/Threonine Kinase Activity | GO Molecular Function |
GO:0004675
|
0.022067627 | 237.8452381 | 1249.077685 |
| Chemokine Binding | GO Molecular Function |
GO:0019956
|
0.022067627 | 208.09375 | 1066.850192 |
| Transforming Growth Factor Beta Receptor Binding | GO Molecular Function |
GO:0005160
|
0.022067627 | 195.8431373 | 992.8792721 |
| Transforming Growth Factor Beta Binding | GO Molecular Function |
GO:0050431
|
0.022067627 | 166.4416667 | 818.2383072 |
| Fibroblast Growth Factor Receptor Binding | GO Molecular Function |
GO:0005104
|
0.022067627 | 158.5079365 | 771.8855079 |
| Chemoattractant Activity | GO Molecular Function |
GO:0042056
|
0.029624348 | 97.83823529 | 431.2061759 |
| Transmembrane Receptor Protein Kinase Activity | GO Molecular Function |
GO:0019199
|
0.029624348 | 92.39351852 | 402.1028593 |
| Nuclear Receptor Coactivator Activity | GO Molecular Function |
GO:0030374
|
0.036322732 | 67.83673469 | 274.9362108 |
| Growth Factor Activity | GO Molecular Function |
GO:0008083
|
0.056306931 | 39.50198413 | 139.3442448 |
| Growth Factor Receptor Binding | GO Molecular Function |
GO:0070851
|
0.058605263 | 34.90877193 | 118.9507894 |
| Cytokine Activity | GO Molecular Function |
GO:0005125
|
0.099120235 | 18.65913371 | 52.28870998 |
| Protein Heterodimerization Activity | GO Molecular Function |
GO:0046982
|
0.099120235 | 17.4638448 | 47.83112533 |
| Receptor Ligand Activity | GO Molecular Function |
GO:0048018
|
0.147761402 | 10.31184486 | 23.09817358 |
| Protein Serine/Threonine Kinase Activity | GO Molecular Function |
GO:0004674
|
0.147761402 | 9.605083089 | 20.87929908 |
| DNA-binding Transcription Activator Activity, RNA Polymerase II-specific | GO Molecular Function |
GO:0001228
|
0.147761402 | 9.436119116 | 20.35634081 |
| Transcription Cis-Regulatory Region Binding | GO Molecular Function |
GO:0000976
|
0.187124035 | 6.878083157 | 12.84164831 |
| DNA Binding | GO Molecular Function |
GO:0003677
|
0.3002633 | 3.776725838 | 5.071604483 |
| Serine/Threonine Protein Kinase Complex | GO Cellular Component |
GO:1902554
|
0.092993612 | 56.31073446 | 218.0400671 |
| Caveola | GO Cellular Component |
GO:0005901
|
0.092993612 | 54.45901639 | 209.1006692 |
| Plasma Membrane Raft | GO Cellular Component |
GO:0044853
|
0.092993612 | 40.97119342 | 145.9806857 |
| Cytoplasmic Vesicle Lumen | GO Cellular Component |
GO:0060205
|
0.092993612 | 29.0628655 | 93.86539744 |
| Ficolin-1-Rich Granule Lumen | GO Cellular Component |
GO:1904813
|
0.092993612 | 27.14617486 | 85.88186048 |
| Membrane Raft | GO Cellular Component |
GO:0045121
|
0.098463269 | 19.66765873 | 56.10889067 |
| Ficolin-1-Rich Granule | GO Cellular Component |
GO:0101002
|
0.098463269 | 18.04189435 | 49.97707265 |
| Secretory Granule Lumen | GO Cellular Component |
GO:0034774
|
0.145073786 | 10.41164021 | 23.41543034 |
| Nucleus | GO Cellular Component |
GO:0005634
|
0.235039666 | 2.594056646 | 4.276747734 |
| Intracellular Membrane-Bounded Organelle | GO Cellular Component |
GO:0043231
|
0.263795096 | 2.149216937 | 2.879175872 |
| Intracellular Organelle Lumen | GO Cellular Component |
GO:0070013
|
0.263795096 | 3.730604288 | 4.971338476 |
| Branching Morphogenesis Of An Epithelial Tube | GO Biological Process |
GO:0048754
|
0.017691536 | 199.53 | 1859.195137 |
| Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor | GO Biological Process |
GO:2000544
|
0.02598143 | 666.2666667 | 4108.590826 |
| Regulation Of Skeletal Muscle Satellite Cell Proliferation | GO Biological Process |
GO:0014842
|
0.02598143 | 666.2666667 | 4108.590826 |
| Regulation Of T Cell Tolerance Induction | GO Biological Process |
GO:0002664
|
0.02598143 | 666.2666667 | 4108.590826 |
| Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation | GO Biological Process |
GO:1905005
|
0.02598143 | 555.1944444 | 3338.153583 |
| Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition | GO Biological Process |
GO:0062043
|
0.02598143 | 555.1944444 | 3338.153583 |
| Positive Regulation Of Epithelial Tube Formation | GO Biological Process |
GO:1905278
|
0.02598143 | 555.1944444 | 3338.153583 |
| Hyaluronan Catabolic Process | GO Biological Process |
GO:0030214
|
0.02598143 | 475.8571429 | 2797.6605 |
| Positive Regulation Of Mesenchymal Cell Proliferation | GO Biological Process |
GO:0002053
|
0.02598143 | 416.3541667 | 2398.853181 |
| Regulation Of CD4-positive, Alpha-Beta T Cell Proliferation | GO Biological Process |
GO:2000561
|
0.02598143 | 416.3541667 | 2398.853181 |
| Myeloid Dendritic Cell Differentiation | GO Biological Process |
GO:0043011
|
0.02598143 | 416.3541667 | 2398.853181 |
| Response To Sterol | GO Biological Process |
GO:0036314
|
0.02598143 | 370.0740741 | 2093.271349 |
| Regulation Of Mesenchymal Cell Proliferation | GO Biological Process |
GO:0010464
|
0.02598143 | 333.05 | 1852.156675 |
| Regulation Of Phospholipase C Activity | GO Biological Process |
GO:1900274
|
0.02598143 | 333.05 | 1852.156675 |
| Positive Regulation Of CD4-positive, Alpha-Beta T Cell Activation | GO Biological Process |
GO:2000516
|
0.02598143 | 302.7575758 | 1657.396457 |
| Positive Regulation Of Vascular Endothelial Cell Proliferation | GO Biological Process |
GO:1905564
|
0.02598143 | 302.7575758 | 1657.396457 |
| Cardiac Left Ventricle Morphogenesis | GO Biological Process |
GO:0003214
|
0.02598143 | 277.5138889 | 1497.032601 |
| Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway | GO Biological Process |
GO:0040037
|
0.02598143 | 277.5138889 | 1497.032601 |
| Myeloid Dendritic Cell Activation | GO Biological Process |
GO:0001773
|
0.02598143 | 277.5138889 | 1497.032601 |
| Positive Regulation Of Alpha-Beta T Cell Differentiation | GO Biological Process |
GO:0046638
|
0.02598143 | 277.5138889 | 1497.032601 |
Host ncRNA KEGG Pathway Enrichment
| Pathways | Category | Adjusted P-value | Odds Ratio | Combined Score |
|---|---|---|---|---|
| Gastric cancer | KEGG Pathway | 0.047447514 | 54.00272109 | 366.4517063 |
| MAPK signaling pathway | KEGG Pathway | 0.090452052 | 26.98767123 | 147.0142007 |
| Pathways in cancer | KEGG Pathway | 0.101936573 | 14.71758034 | 63.33472415 |
| Proteasome | KEGG Pathway | 0.101936573 | 73.88148148 | 305.5511081 |
| Adherens junction | KEGG Pathway | 0.101936573 | 47.43571429 | 175.7682775 |
| Melanoma | KEGG Pathway | 0.101936573 | 46.76525822 | 172.6369048 |
| Pancreatic cancer | KEGG Pathway | 0.101936573 | 44.26222222 | 161.0301743 |
| Chronic myeloid leukemia | KEGG Pathway | 0.101936573 | 44.26222222 | 161.0301743 |
| Colorectal cancer | KEGG Pathway | 0.101936573 | 39.03529412 | 137.247272 |
| TGF-beta signaling pathway | KEGG Pathway | 0.101936573 | 35.66308244 | 122.2612325 |
| AGE-RAGE signaling pathway in diabetic complications | KEGG Pathway | 0.101936573 | 33.49158249 | 112.7746184 |
| Chagas disease | KEGG Pathway | 0.101936573 | 32.82508251 | 109.8901519 |
| Th17 cell differentiation | KEGG Pathway | 0.101936573 | 31.26886792 | 103.2073411 |
| Osteoclast differentiation | KEGG Pathway | 0.101936573 | 26.27910053 | 82.31344422 |
| Relaxin signaling pathway | KEGG Pathway | 0.101936573 | 25.86588542 | 80.62271997 |
| FoxO signaling pathway | KEGG Pathway | 0.101936573 | 25.46538462 | 78.99021819 |
| Signaling pathways regulating pluripotency of stem cells | KEGG Pathway | 0.101936573 | 23.29929577 | 70.27102159 |
| Spinocerebellar ataxia | KEGG Pathway | 0.101936573 | 23.29929577 | 70.27102159 |
| Breast cancer | KEGG Pathway | 0.101936573 | 22.65639269 | 67.72053348 |
| Cellular senescence | KEGG Pathway | 0.101936573 | 21.3311828 | 62.5205994 |
Virus RNA Sequence Information
|
>OM222702.1 Hepatitis C virus subtype 1b isolate GLT1, complete genome
GCCAGCCCCCGATTGGGGGCGACACTCCACCATAGATCACTCCCCTGTGAGGAACTACTGTCTTCACGCA
GAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTGCAGCCTCCAGGACCCCCCCTCCCGGGAGAGCCA
TAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCAGGACGACCGGGTCCTTTCTTGGATCAACCCG
CTCAATGCCTGGAGATTTGGGCGTGCCCCCGCGAGACTGCTAGCCGAGTAGTGTTGGGTCGCGAAAGGCC
TTGTGGTACTGCCTGATAGGGTGCTTGCGAGTGCCCCGGGAGGTCTCGTAGACCGTGCACCATGAGCACG
AATCCTAAACCTCAAAGAAAAACCAACCGTAACACCAACCGCCGCCCACAGGACGTCAAGTTCCCGGGTG
GTGGTCAGATCGTTGGTGGAGTTTACCTGTTGCCGCGCAGGGGCCCCAGATTGGGTGTGCGCGCGACTAG
GAAGACTTCCGAGCGGTCGCAACCTCGTGGAAGGCGACAACCTATCCCCAAGGCTCGCCAGCCCGAGGGC
AGGGCCTGGGCTCAGCCCGGGTACCCTTGGCCCCTCTATGGCAATGAGGGCATGGGGTGGGCAGGATGGC
TCCTGTCACCCCGCGGCTCTCGGCCTAGTTGGGGCCCCACGGACCCCCGGCGTAGGTCGCGTAATTTGGG
TAAGGTTATCGATACCCTCACATGCGGCTTCGCCGACCTCATGGGGTACATTCCGCTCGTCGGCGCTCCC
CTAGGGGGCGCTGCTAGGGCCCTGGCGCATGGCGTCCGGGTTTTAGAAGACGGCGTGAATTATGCAACAG
GGAATCTGCCCGGTTGCTCTTTCTCTATCTTCCTCTTGGCTCTGCTGTCCTGCTTGACCATCCCAGCATC
CGCTTATGAAGTGCGCAACGTGTCCGGGGTGTACCACGTCACGAACGATTGCTCCAACGCGAGTATCGTG
TATGAGGTGGAGGACATGATCATGCACACCCCCGGGTGCGTGCCCTGCGTTCGGGAGAACAACTCCTCCC
GTTGCTGGGTAGCGCTTACCCCCACGCTTGCGGCCAGGAACTCCAGCATCCCCACTGCGACAATACGACG
CCACGTCGATTTGCTCGTTGGGGCGGCTGCTTTCTGCTCCGCCATGTACGTGGGGGATCTCTGCGGATCT
GTTTTCCTTGTCTCCCAGCTGTTCACCTTCTCGCCCCGCCGGCATGAGACAGTGCAAGACTGCAATTGTT
CAATCTATCCTGGCCACGTATCAGGTCACCGCATGGCTTGGGATATGATGATGAACTGGTCACCTACAGC
AGCTTTAGTGGTATCGCAGTTACTCCGACTCCCACAAGCTATCGTGGACATGGTGGCGGGGGCCCACTGG
GGAGTCCTGGCGGGCCTTGCCTACTATTCCATGGTGGGGAACTGGGCTAAGGTTTTGATTGTGATGCTAC
TCTTTGCCGGCGTTGACGGAGAAACCCATGTGACAGGGGCGACGCAAGGCCGTGCTGCCAGCTCATTCAC
AGCCCTCTTTTCATCTGGGGCGTCTCAGAAGATCCAGCTTGTAAACACCAACGGCAGTTGGCACATCAAC
AGAACTGCCTTGAACTGCAATGACTCCCTCCAAACTGGGTTCCTTGCCGCGCTGTTCTATAAGCACAGGT
TCAACGCCTCCGGGTGCCCAGAACGCATGGCCAGCTGCCACCCCATCAACGAATTTGATCAGGGGTGGGG
TCCCATCACTTACGCTGGGCCTAGCGGCTTGGACCAGAGGCCTTACTGTTGGCACTACGCACCTCAACCG
TGTGGTATCGTGCCCGCGTCGCAGGTGTGTGGCCCGGTGTATTGCTTCACCCCAAGCCCTGTTGTGGTGG
GGACGACTGATCGGTCCGGCGCCCCAACGTACAACTGGGGGGAGAATGAGACGGACGTGCTGCTCCTCAA
CAACACGCGGCCGCCGCAGGGCAACTGGTTCGGCTGTACATGGATGAATGGCACTGGGTTCACCAAGACG
TGCGGGGGCCCCCCGTGCGACATCGGGGGGGCCGGCAACAACACCTTGATCTGTCCCACGGACTGCTTCC
GGAAGCACCCCGAGGCCACTTACGCCAAGTGCGGTTCTGGGCCTTGGTTAACACCTAGGTGCTTGGTTGA
CTACCCATACAGGCTTTGGCACTACCCCTGCACCGTTAACTTCACCATCTTCAAGATCAGGATGTATGTG
GGGGGCGTGGAGCACAGGCTCGACGCCGCGTGCAATTGGACTCGAGGAGAGCGTTGTGACTTGGAGGACA
GGGATAGATCAGAGCTTAGCCCACTGCTCTTGTCTACGACAGAGTGGCAGGTATTGCCCTGCTCCTTCAC
CACCCTACCCGCTTTGTCCACTGGCTTGATCCACCTTCATCAGAACATCGTGGACGTGCAATACCTGTAC
GGTGTAGGGTCGGCAATTGTCTCCTTTGTCATCAAATGGGAGTATGTCCTGTTGCTCTTCCTTCTCCTGG
CAGACGCGCGCGTCTGTGCTTGCCTATGGATGATGGTGATGATAGCCCAGGCTGAGGCCGCCTTGGAGAA
CCTGGTGGTCCTCAACGCGGCGTCCCTGGCCGGAGCGCACGGCACCCTCTCCTTCCTCCTGTTCTTCTGT
GCCGCCTGGTACATCAAGGGCAGGCTGATCCCTGGGGCGGCATATGCTATCTACGGCGTATGGCCGCTGC
TCTTGCTCCTGCTGGCATTACCTCCACGAACATACGCCATGGACCGGGAGATGGCTGCGTCATGCGGAGG
CGGGGTTTTTGTAGGCCTGGTTCTTTTGACCTTGTCACCACACTATAAAGTGTTCCTCGCTAAGCTCATA
TGGTGGTTGCAGTATCTTATCACCAGAGCTGAGGCGTGCTTACAAGTGTGGATCCCCCCCCTTAACATCC
GGGGGGGCCGCGACGCCATCATCCTCCTCACGTGCGTGATCCACCCAGAGCTAATCTTTGACATCACCAA
GCTCTTGCTCGCCATACTCGGTCCAGTCATGGTGTTCCAGGCCGGTATAACCAGAGTGCCGTACTTTGTG
CGCGCTCAGGGGCTCATTCGCGCATGCGCGCTGGTGCGGAAAGCCGCTGGGGGTCAGTATGTTCAGATGG
CTCTCATGAAGCTGGCCGCACTGACGGGTACGTACGTTTATGACCATCTTACTCCACTGCGGGACTGGGC
CCACGCGGGCCTGCGAGACCTCGCGGTGGCAGTCGAGCCCGTCGTCTTCTCCGACATGGAAACCAAGATC
ATTACCTGGGGGGCAGACACCGCAGCGTGCGGGGACATCATCTCGGGTCTACCTGTCTCCGCCCGAAGGG
GGAGGGAGGTACTCTTGGGACCGGCCGACAGTTTTGAGGGGCAGGGGTGGCGACTCCTTTCGCCCATCAC
GGCCTACGCCCAACAGACGCGGGGCATGCTTAGCTGTATCATCACTAGCCTCACAGGCCGGGACAAGAAC
CAGGTCGAGGGGGAGGTCCAAGTGGTCTCCACCGCGACGCAATCCTTCCTGGCGACCTGCGTCAATGGCG
TGTGCTGGACTGTCTTCCATGGTGCCGGCCCCAAGACCCTAGCCGGCCCAAAAGGGCCGATCACCCAAAT
GTACACCAATGTAGACCAGGACCTCGTCGGTTGGCAAGCGCCCCCCGGGGCGCGTTCCTTGACACCATGC
ACCTGCGGCAGCTCGGACCTTTACTTGGTCACGCGGCATGCCGATGTCATCCCGGTGCGCCGGCGGGGCG
ACAGCAGAGGGAGCTTGCTCTCCCCCAGGCCCATTTCCTACTTGAAGGGCTCTTCGGGTGGTCCGCTGCT
CTGCCCCTCGGGGCACGTCGTGGGCATCTTCCGGGCTGCCGTGTGCACCCGGGGGGTCGCGAAGGCGGTG
GACTTCATACCCGTTGAGTCCATGGAAACTACCATGCGGTCCCCGGTCTTTACGGACAATTCGACCCCGC
CGGCGGTACCGCAGTCATTCCAAGTGGCCCATCTACACGCTCCCACTGGCAGCGGCAAAAGCACCAAGGT
GCCGGCTGCATATGCAGCCCAAGGGTATAAGGTGCTTGTCCTGAACCCGTCCGTTGCCGCCACTTTAGGC
TTTGGAACGTACATGTCTAAGGCACATGGTGTTGACCCCAACATCAGAACCGGGGTAAGGACCATCACCA
CGGGTGCCCCCATTACGTACTCTACCTACGGCAAGTTCCTTGCCGACGGTGGTTGCTCTGGGGGCGCCTA
TGACATCATAATATGTGATGAGTGCCACTCAACTGACTCGACTTCCATCCTGGGCATCGGTACAGTCCTG
GACCAAGCGGAGACGGCTGGAGCGCGGCTTGTCGTGCTCGCCACCGCTACACCTCCGGGATCGGTCACCG
TGCCACATTCTAACATTGAGGAGGTGGCTCTGTCCACCACTGGAGAGATCCCCTTCTACGGCAAAGCCAT
CCCAATTGAGACCATCAAGGGGGGGAGGCACCTCATTTTCTGCCATTCCAAAAAGAAATGTAACGAGCTC
GCCGCGCAGCTGTCAAACCTCGGACTCAACGCTGTAGCGTATTATCGGGGCCTTGACGTGTCCGTCATAC
CGACCAGCGGAGATGTCGTTGTCGTAGCAACGGACGCTCTAATGACGGGCTATACCGGCGACTTTGACTC
AGTGATCGACTGTAATACATGCGTCATCCAGACAGTCGATTTCAGCTTGGACCCTACCTTCACCATCGAG
ACGACGACCGTACCCCAAGATGCGGTGTCGCGCTCACAGCGGCGGGGCAGGACTGGTAGGGGCAGAATGG
GTATCTATAGGTTTGTGGCTCCAGGAGAACGGCCCTCGGGCATGTTCGATTCCTCGGTCCTGTGTGAGTG
CTATGACGCGGGTTGTGCTTGGTACGAGCTTACGCCCGCTGAGACCTCAGTTAGGTTGCGGGCTTACCTA
AATACACCAGGGTTGCCCGTTTGCCAGGACCATCTGGAGTTCTGGGAGAGCGTCTTCACAGGCCTCACCC
ACATAGACGCCCATTTCTTGTCCCAAACCAAACAGGCAGGAGACAACTTCCCCTACCTGGTAGCATACCA
GGCCACAGTGTGCGCCAGGGCTCAGGCTCCACCTCCATCGTGGGACCAAATGTGGAAGTGTCTCATACGG
CTAAAGCCTACGTTGCATGGGCCAACGCCTCTGCTGTATAGGCTGGGAGCCGTCCAAAACGAGGTCACCC
TCACACACCCCATAACCAAATACATCATGGCATGCATGTCGGCCGACCTGGAGGTCGTCACCAGCACCTG
GGTGTTGGTAGGCGGAGTTCTTGCAGCTCTGGCCGCGTATTGCCTGACAACAGGCAGCGTGGTCATTGTG
GGCAGGATCATCTTGTCCGGGAGGCCGGCTGTCGTACCTGACAGAGAGGTCCTCTACCAGGAGTTCGATG
AGATGGAAGAGTGTGCATCACACCTCCCTTACATCGAGCATGGAATGCAGCTCGCTGAGCAATTCAAGCA
GAAAGCGCTCGGGTTGTTGCAAACAGCTACCAAGCAGGCGGAGGCTGCTGCTCCCGTGGTGGAGTCCAAG
TGGCGAGCCCTTGAGGCCTTCTGGGCGAAGCACATGTGGAACTTCATCAGCGGGATACAATACCTGGCGG
GCCTGTCCACTCTACCTGGGAATCCCGCAATAGCATCATTAATGGCATTCACAGCCTCCATCACCAGCCC
GCTTACCACCCAAACCACTCTCTTGCTTAACATCTTGGGAGGATGGGTGGCCGCCCAACTCGCCCCCCCC
GGTGCTGCCTCGGCTTTCGTGGGCGCCGGTATTGCCGGCGCGGCTGTTGGCAGCATAGGTCTTGGGAAGG
TGCTTGTGGACATCCTGGCGGGCTATGGGGCAGGGGTGGCAGGCGCACTCGTGGCCTTTAAGGTCATGAG
TGGCGAGATGCCCTCCACCGAGGACCTGGTCAACTTACTCCCTGCCATTCTCTCTCCCGGGGCCCTGGTC
GTTGGGGTCGTGTGTGCAGCGATACTGCGCCGGCACGTGGGCCCGGGGGAGGGAGCTGTGCAGTGGATGA
ACCGGCTGATAGCGTTCGCCTCACGGGGTAACCACGTCTCCCCCACACACTATGTGCCTGAGAGCGACGC
CGCAGCGCGTGTTACTCAGATCCTCTCCAGCCTTACCATCACTCAGCTGTTGAAGAGACTCCACCAATGG
ATCAATGAAGACTGCTCCACGCCATGCTCCGGCTCGTGGCTAAGGGATGTCTGGGAGTGGATATGCACGG
TGTTGACTGACTTCAAGACCTGGCTCCAGTCCAAGCTCCTGCCGCGGTTGCCGGGAGTCCCTTTCCTCTC
ATGCCAGCGTGGGTACAGGGGAGTCTGGCGGGGAGACGGCATCATGCATACCACCTGCCCATGTGGAGCA
CAAATCACCGGACATGTCAAAAACGGTTCCATGAGGATCGTTGGGCCTAGGACCTGCAGCAACACGTGGC
ACGGAACATTCCCCATCAACGCATACACCACGGGCCCTTGCACACCCTCCCCGGCGCCAAACTATTCCAG
GGCGCTGTGGCGGGTAGCTGCTGAGGAGTACGTGGAGGTTACGCGGGTGGGGGATTTCCACTACGTGACG
GGCATGACCACTGACAACATAAAGTGCCCGTGCCAGGTCCCGGCCCCCGAATTCTTCACAGAGGTGGATG
GGGTGCGGCTGCACAGGTACGCTCCGGCGTGCAAACCTCTCCTACGGGATGAGGTCACATTCCAGGTCGG
GCTCAACCAATTCGTGGTTGGGTCGCAGCTCCCATGTGAGCCCGAACCGGATGTGGCGGTGCTAACTTCC
ATGCTCACCGACCCCTCCCACATTACAGCAGAGACGGCCAAGCGTAGACTGGCCAGGGGGTCTCCCCCCT
CCTTGGCCAGCTCTTCCGCTAGCCAGTTGTCTGCGATTTCCTTGAAGGCGGCATGCACTACACACCACAA
CTCCCCGGACGTCGACCTCGTCGAGGCCAACCTCCTGTGGAGGCAGGAGATGGGCGGGACCATCACCCGC
GTGGAGTCAGAGAACAAGGTGGTGATTCTGGACTCCTTCGAGCCGCTTCGAGCGGAGGAGGATGAGAGGG
AAGTGTCCGTTGCGGCGGAGATCCTGCGGAAATCCAAAAGGTTCCCCCCAGCGCTGCCCATATGGGCACG
CCCGGATTACAACCCTCCGCTGTTGGAGTCCTGGAAGAACCCAGACTATGTCCCTCCGGTGGTACATGGG
TGCGCGCTACCACCTACCAAAGCCCCTCCAGTACCGCCTCCACGGAGGAAGAGGACAGTTGTCCTAACTG
AGTCTACTGTGTCTTCTGCCCTGGCGGAGCTTGCCGCGAAGACTTTCGGCGGCTCCGAATCGTCAGCCGC
CGATAGCGGCACGGCGACTGCCCCTCCAGACCAGCCCTCCGACAACGGCGACACAGGATCCGACGTTGAG
TCGTACTCCTCCATGCCCCCCCTCGAGGGGGAGCCGGGGGATCCCGATCTCAGCGACGGGTCTTGGTCTA
CCGTGAGCGAGGAGGCTGGTGATAATGTAGTCTGCTGCTCGATGTCCTACACATGGACAGGCGCTCTGAT
CACGCCATGCGCCGCGGAGGAAAGCAAGCTGCCCATCAATGCGCTGAGCAACTCTTTGCTGCGTCACCAT
AACATGGTTTATGCTACAACATCCCGCAGCGCAAGCCAGCGGCAGAAGAAGGTCACCTTTGACAGACTGC
AAGTCCTGGATGATCACTACCGGGACGTGCTCAAGGAGATGAAGGCGAAGGCGTCCACAGTTAAGGCCAA
ACTTCTATCTGTGGAGGAGGCCTGCAAGCTGACGCCCCCACATTCGGCCAGATCAAAATTTGGCTATGGG
GCAAAGGACGTCCGGAACCTATCCAGCAAGGCCATTAAACACATCCGCTCCGTGTGGGAGGACTTGCTGG
AAGACACTCAAACACCAATTGACACCACCATCATGGCAAAAAACGAGGTTTTCTGCGTCCAACCAGAAAA
GGGAGGCCGCAAGCCAGCTCGCCTTATCGTGTTCCCAGACTTGGGAGTGCGTGTGTGCGAAAAGATGGCC
CTTTACGACGTGGTCTCCACCCTTCCTCAGGCCGTGATGGGCTCCTCTTACGGGTTCCAATACTCTCCTG
GACAGCGGGTCGAGTTCCTGGTGAATGCCTGGAAATCAAAGAAATGCCCTATGGGCTTCTCATATGACAC
CCGCTGTTTTGACTCAACAGTCACCGAGAACGATATCCGTGTTGAGGAGTCAATTTACCAATGTTGTGAC
TTGGCCCCCGAAGCCAGGCAGGCTATAAGGTCGCTCACAGAGCGGCTTTATATCGGGGGTCCCCTGACCA
ATTCAAAAGGGCAGAACTGCGGTTATCGCCGGTGCCGCGCAAGCGGTGTACTGACGACCAGCTGCGGTAA
TACCCTCACATGTTACTTGAAGGCCACTGCAGCCTGTCGAGCTGCGAAGCTCCAGGACTGCACAATGCTC
GTGTGCGGAGACGACCTTGTCGTTATCTGTGAAAGCGCTGGAACCCAGGAGGACGAGGCGAACCTACGAG
CCTTTGCACTGGCTATGACTAGGTACTCTGCCCCCCCCGGGGACCCGCCCCAACCAGAATACGACTTGGA
GCTGATAACATCATGCTCTTCTAATGTGTCGGTCGCGCACGATGCATCTGGCAAAAGAGTGTACTACCTC
ACCCGTGATCCCACCACCCCTCTCGCGAGGGCTGCGTGGGAGACAGCTAGACACACTCCAGTTAACTCCT
GGCTAGGCAACATCATCATGTTTGCACCCACCTTATGGGCAAGGATGATTTTGATGACTCACTTCTTCTC
CATCCTTCTGGCCCAGGAGCAACTTGAGAAAGCCCTAGATTGCCAGATCTACGGGGCTTGTTACTCCATT
GAGCCACTTGACCTACCTCAGATCATTCAACGACTCCATGGCCTTAGCGCATTTTCACTCCACAGTTACT
CTCCAGGTGAGATCAATAGGGTGGCTGCATGCCTCAGGAAACTTGGGGTACCACCCTTGCGAGCCTGGAG
ACATCGGGCCAGAAGTGTCCGCGCTAAGCTACTGTCTCGGGGGGGGAGGGCCGCCACTTGTGGCAAGTAC
CTCTTCAACTGGGCAGTAAGGACCAAGCTCAAACTCACTCCAATTCCGGCCGCATCCCAGCTGGACTTGT
CCGGCTGGTTCGTTGCTGGCTACAGCGGGGGAGACATATATCACAGCTTGTCTCGTGCCCGACCCCGCTG
GTTCATGTGGTGCCTACTCCTACTTTCCGTAGGGGTAGGCATCTACCTGCTCCCCAACCGATGAACGGGG
AGCTAAACACTCCAGGCCAATAGGCCGTTTCCCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTCCTTTTTTTTTTTTATTTTCTATCCTTCTTTTGGTGGCTCCATCTTAGCCCTAGTCACGGCTAG
CTGTGAAAGGTCCGTGAGCCGCATGACTGCAGAGAGTGCTGATACTGGCCTCTCTGCAGATCATGT
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