Protein Name
Aldo-keto reductase family 1 member B1
  Gene Name
AKR1B1
  Host Species
Homo sapiens
  Uniprot Entry Name
ALDR_HUMAN
  Protein Families
Aldo/keto reductase family
  EC Number
1.1.1.21; 1.1.1.300; 1.1.1.372; 1.1.1.54
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
231
Uniprot ID
P15121
Ensembl ID
ENSG00000085662
HGNC ID
381
  Related KEGG Pathway
Pentose and glucuronate interconversions hsa00040            Pathway Map 
Fructose and mannose metabolism hsa00051            Pathway Map 
Galactose metabolism hsa00052            Pathway Map 
Metabolic pathways hsa01100            Pathway Map 
Glycerolipid metabolism hsa00561            Pathway Map 
Folate biosynthesis hsa00790            Pathway Map 
  3D Structure

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Sindbis virus 5'UTR - 3'UTR RNA Info Cross-link-assisted mRNP purification (CLAMP) HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 2 h . .
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -11.50098667 FZR = 1.3159E-27
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -2.873965126 FZR = 1
Hepatitis E virus 3'UTR RNA Info RNA-protein interaction detection (RaPID) assay coupled to liquid chromatography with tandem mass spectrometry (LC-MS/MS) HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney . . .
Sindbis virus (strain Toto1101) 5'UTR - 3'UTR RNA Info Cross-link-assisted mRNP purification (CLAMP) and UV cross-linking and immunoprecipitation sequencing (CLIP-seq) HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 2 h . .
Sindbis virus (strain Toto1101) 5'UTR - 3'UTR RNA Info Cross-link-assisted mRNP purification (CLAMP) and UV cross-linking and immunoprecipitation sequencing (CLIP-seq) HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 2 h . .
Sindbis virus (strain Toto1101) 5'UTR - 3'UTR RNA Info Cross-link-assisted mRNP purification (CLAMP) and UV cross-linking and immunoprecipitation sequencing (CLIP-seq) HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 2 h . .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 0.00673233406700243 .
Drug Name DrunkBank ID Pubchem ID TTD ID REF
DABELOTINE . 177949  D01FDL  DGIdb
EPALRESTAT . 1549120  D03KOZ  DGIdb
epalrestat . 1549120  D03KOZ  DrugCentral
FIDARESTAT . 160024  D00EWR  DGIdb
flufenamic acid . 3371  D0B2WJ  DrugCentral
gossypol . 3503  D0Z0HH  DrugCentral
hymecromone . . . DrugCentral
indomethacin . 3715  D0R1RS  DrugCentral
LIDORESTAT . 157839  D04BFU  DGIdb
mefenamic acid . 4044  D05FTJ  DrugCentral
mezlocillin . 656511  D00NJJ  DrugCentral
nitazoxanide . 41684  D08EBN  DrugCentral
OXILOFRINE . 688009  D07QLG  DGIdb
phenylacetic acid . . . DrugCentral
phenylbutanoic acid . . . DrugCentral
quercetin . 5280343  D0K8KX  DrugCentral
RANIRESTAT . 153948  D0K8TI  DGIdb
SORBINIL . 337359  D02CGC  DGIdb
SULINDAC . 1548887  D0Z5IU  DGIdb
sulindac . 1548887  D0Z5IU  DrugCentral
tolmetin . 5509  D09BHB  DrugCentral
TOLRESTAT . 53359  D0Q7QY  DGIdb
tolrestat . 53359  D0Q7QY  DrugCentral
troglitazone . 5591  D06XZW  DrugCentral
URACIL . 1174  D0Y0DG  DGIdb
ZENARESTAT . 5724  D0C7KK  DGIdb
ZOPOLRESTAT . 1613  D06EDT  DGIdb

MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
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