Host Protein General Information

  Protein Name
NAD(P)H dehydrogenase [quinone] 1
  Gene Name
NQO1
  Host Species
Homo sapiens
  Uniprot Entry Name
NQO1_HUMAN
  Protein Families
NAD(P)H dehydrogenase (quinone) family
  EC Number
1.6.5.2
  Subcellular Location
Cytoplasm; cytosol
  External Link
NCBI Gene ID
1728
Uniprot ID
P15559
Ensembl ID
ENSG00000181019
HGNC ID
2874
  Related KEGG Pathway
Pathways in cancer hsa05200            Pathway Map 
Chemical carcinogenesis - reactive oxygen species hsa05208            Pathway Map 
Hepatocellular carcinoma hsa05225            Pathway Map 
Fluid shear stress and atherosclerosis hsa05418            Pathway Map 
Metabolic pathways hsa01100            Pathway Map 
Biosynthesis of cofactors hsa01240            Pathway Map 
Ubiquinone and other terpenoid-quinone biosynthesis hsa00130            Pathway Map 
  3D Structure
PDB ID: 1D4A 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Dengue virus 5'UTR - 3'UTR RNA Info UV cross-linking (UVX) HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver 30 h . .
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -20.06524617 FZR = 1.93713E-86
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -3.124810859 FZR = 1
Dengue virus 2 (strain NGC) 5'UTR - 3'UTR RNA Info UV cross-linking followed by antisense-mediated affinity purification and mass spectrometry HuH-7 Cells (Human hepatocellular carcinoma cell) . Liver 30 h . .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 9.97807845018227e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ACETAMINOPHEN . 1983  D0U5QK  DGIdb
bisantrene . . . DrugCentral
CHEMBL1287866 . 6035704  D00DSW  DGIdb
CHEMBL1287867 . 5905819  D08WKQ  DGIdb
CHEMBL1287895 . 5864101  D06GRP  DGIdb
CHEMBL1288253 . 5466653  D02GDG  DGIdb
CHEMBL1288281 . 5884626  D0M7RM  DGIdb
CHEMBL476968 . 5351382  D0UB3V  DGIdb
CISPLATIN . 5702198  D0U5HU  DGIdb
dicoumarol . 54676038  D02TJS  DrugCentral
DICUMAROL . 54676038  D02TJS  DGIdb
DOXORUBICIN . 31703  D07VLY  DGIdb
FLUOROURACIL . 3385  D05LEO  DGIdb
HYDROQUINONE . 785  D03UOT  DGIdb
IMATINIB . 5291  D0AZ3C  DGIdb
ITRACONAZOLE . 55283  D0V4IB  DGIdb
MENADIONE . 4055  D03GET  DGIdb
OXALIPLATIN . 9887053  D0Y3ME  DGIdb
SULFORAPHANE . 5350  D0X4IO  DGIdb
VATIQUINONE . 46184405  D0OQ8Q  DGIdb
WARFARIN . 54678486  D0E3OF  DGIdb

Protein Sequence Information

MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
    Click to Show/Hide