Virus General Information

  Virus Name
Hepatitis E virus (HEV)
  Lineage
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes; Hepelivirales
  Virus Molecule Type
ssRNA(+)
  Sequence ID
NC_001434.1
  Genome Type
Non-segmented
  Related Host Homo sapiens
  Related Disease Viral hepatitis Fulminant hepatic failure Hepatitis E
  External Link
 Taxon ID 291484
 Virus-Host DB https://www.genome.jp/virushostdb/291484
 KEGG BRITE ID NC_001434

Virus Virion and Genome Information

    Virion Information
Quasi-enveloped, spherical, about 32-34 nm in diameter. The RNA genome is enclosed within a capsid that is composed of 180 capsid proteins, assembled into a T=3 icosahedral particle . The HEV particles present in feces and bile are non-enveloped, while those in circulating blood and culture supernatants are covered with a cellular membrane, similar to enveloped viruses.
    GENOME Information
Monopartite, linear, ssRNA(+) genome of 7.2 kb. The 5' end is capped and the 3' terminus is polyadenylated. Their is no VPg at the 5'-terminus of the genome. The genome consists of three partially overlapping ORFs.

Virus-RNA -- Host-Protein Interaction

RNA Binding Site RNA Detail Protein Name Host Species Uniprot ID Protein Detail
3'UTR RNA Info 26S proteasome non-ATPase regulatory subunit 7 Homo sapiens P51665 Pro Info
3'UTR RNA Info 26S proteasome non-ATPase regulatory subunit 8 Homo sapiens P48556 Pro Info
3'UTR RNA Info 40S ribosomal protein SA Homo sapiens P08865 Pro Info
3'UTR RNA Info Adenylate kinase isoenzyme 1 Homo sapiens P00568 Pro Info
3'UTR RNA Info Aldo-keto reductase family 1 member A1 Homo sapiens P14550 Pro Info
3'UTR RNA Info Aldo-keto reductase family 1 member B1 Homo sapiens P15121 Pro Info
3'UTR RNA Info Aldo-keto reductase family 1 member C4 Homo sapiens P17516 Pro Info
3'UTR RNA Info AN1-type zinc finger protein 1 Homo sapiens Q8TCF1 Pro Info
3'UTR RNA Info Barrier-to-autointegration factor Homo sapiens O75531 Pro Info
3'UTR RNA Info Cofilin-2 Homo sapiens Q9Y281 Pro Info
3'UTR RNA Info CTP synthase 2 Homo sapiens Q9NRF8 Pro Info
3'UTR RNA Info Dephospho-CoA kinase domain-containing protein Homo sapiens Q8WVC6 Pro Info
3'UTR RNA Info DNA replication licensing factor MCM4 Homo sapiens P33991 Pro Info
3'UTR RNA Info DnaJ homolog subfamily C member 7 Homo sapiens Q99615 Pro Info
3'UTR RNA Info F-actin-capping protein subunit beta Homo sapiens P47756 Pro Info
3'UTR RNA Info Far upstream element-binding protein 2 Homo sapiens Q92945 Pro Info
3'UTR RNA Info Far upstream element-binding protein 3 Homo sapiens Q96I24 Pro Info
3'UTR RNA Info Fragile X messenger ribonucleoprotein 1 Homo sapiens Q06787 Pro Info
3'UTR RNA Info Glyceraldehyde-3-phosphate dehydrogenase Homo sapiens P04406 Pro Info
3'UTR RNA Info Heat shock protein 105 kDa Homo sapiens Q92598 Pro Info

Virus-RNA -- Host-ncRNA Interaction

RNA Binding Site RNA Detail HncRNA Name Host Species External Link HncRNA Detail
3'UTR RNA Info hsa-miR-298 Homo sapiens miRBase HncRNA Info
3'UTR RNA Info hsa-miR-328-5p Homo sapiens miRBase HncRNA Info
3'UTR RNA Info hsa-miR-539-5p Homo sapiens miRBase HncRNA Info

Virus Sequence Information

>NC_001434.1 Hepatitis E virus, complete genome GCCATGGAGGCCCATCAGTTTATTAAGGCTCCTGGCATCACTACTGCTATTGAGCAGGCTGCTCTAGCAG CGGCCAACTCTGCCCTTGCGAATGCTGTGGTAGTTAGGCCTTTTCTCTCTCACCAGCAGATTGAGATCCT TATTAACCTAATGCAACCTCGCCAGCTTGTTTTCCGCCCCGAGGTTTTCTGGAACCATCCCATCCAGCGT GTTATCCATAATGAGCTGGAGCTTTACTGTCGCGCCCGTTCCGGCCGCTGCCTTGAAATTGGTGCCCACC CCCGCTCAATAAATGATAACCCTAATGTGGTCCACCGCTGCTTCCTCCGCCCTGCCGGGCGTGATGTTCA GCGTTGGTATACTGCCCCTACCCGCGGGCCGGCTGCTAATTGCCGGCGTTCCGCACTGCGCGGGCTCCCC GCTGCTGACCGCACTTACTGCTTCGACGGGTTTTCTGGCTGTAACTTTCCCGCCGAGACTGGCGTCGCCC TCTATTCTCTCCATGATATGTCACCATCTGATGTCGCCGAGGCTATGTTCCGCCATGGTATGACGCGGCT TTACGCTGCCCTCCACCTCCCGCCTGAGGTCCTGTTGCCCCCTGGCACATACCGCACCGCGTCGTACTTG CTGATCCATGACGGCAGGCGCGTTGTGGTGACGTATGAGGGTGACACTAGTGCTGGTTATAACCACGATG TTTCCAACCTGCGCTCCTGGATTAGAACCACTAAGGTTACCGGAGACCATCCTCTCGTCATTGAGCGGGT TAGGGCCATTGGCTGCCACTTTGTCCTCTTACTCACGGCAGCCCCGGAGCCATCACCTACGCCCTATGTT CCTTACCCCCGGTCTACCGAGGTCTATGTCCGATCGATCTTCGGCCCGGGTGGTACCCCCTCCCTATTTC CAACCTCATGCTCCACTAAGTCGACCTTCCATGCTGTCCCTGCCCATATCTGGGACCGTCTCATGTTGTT CGGGGCCACCCTAGATGACCAAGCCTTTTGCTGCTCCCGCCTAATGACTTACCTCCGTGGCATTAGCTAC AAGGTTACTGTGGGCACCCTTGTTGCCAATGAAGGCTGGAACGCCTCTGAGGTCGCTCTTACAGCTGTCA TCACTGCCGCCTACCTTACCATCTGCCACCAGCGGTACCTCCGCACTCAGGCTATATCTAAGGGGATGCG CCGTCTGGAGCGGGAGCATGCTCAGAAGTTTATAACACGCCTCTACAGTTGGCTCTTTGAGAAGTCCGGC CGTGATTATATCCCCGGCCGTCAGTTGGAGTTCTACGCTCAGTGTAGGCGCTGGCTCTCGGCCGGCTTTC ATCTTGACCCACGGGTGTTGGTTTTTGATGAGTCGGCCCCCTGCCACTGTAGGACTGCGATTCGTAAGGC GGTCTCAAAGTTTTGCTGTTTTATGAAGTGGCTGGGCCAGGAGTGCACCTGTTTCCTACAACCTGCAGAA GGCGCCGTCGGCGACCAGGGCCATGACAACGAGGCCTATGAGGGGTCTGATGTCGACCCCGCTGAATCCG CTATTAGTGACATATCTGGGTCCTACGTCGTCCCTGGCACTGCCCTCCAACCGCTTTACCAAGCCCTTGA CCTCCCCGCTGAGATTGTGGCTCGTGCAGGCCGGCTGACCGCCACAGTAAAGGTCTCCCAGGTCGACGGG CGGATCGATTGTGAGACCCTTCTCGGTAATAAAACCTTCCGCACGTCGTTTGTTGACGGGGCGGTTTTAG AGACTAATGGCCCAGAGCGCCACAATCTCTCTTTTGATGCCAGTCAGAGCACTATGGCCGCCGGCCCTTT CAGTCTCACCTATGCCGCCTCTGCTGCTGGGCTGGAGGTGCGCTATGTCGCTGCCGGGCTTGACCACCGG GCGGTTTTTGCCCCCGGCGTTTCACCCCGGTCAGCCCCTGGCGAGGTCACCGCCTTTTGTTCTGCCCTAT ACAGGTTTAATCGCGAGGCCCAGCGCCTTTCGCTCACCGGTAATTTTTGGTTCCATCCTGAGGGGCTCCT TGGCCCCTTTGCCCCGTTTTCCCCCGGGCATGTTTGGGAGTCGGCTAATCCATTCTGTGGAGAGAGCACA CTTTACACCCGCACTTGGTCGGAGGTTGATGCTGTTTCTAGTCCAGCCCAGCCCGACTTAGGTTTTATAT CTGAGCCTTCTATACCTAGTAGGGCCGCCACACTTACCCCGGCGGCCCCTCTACCCCCCCCTGCACCGGA TCCTTCCCCTACTCCCTCTGCTCCGGCGCGTGGTGAGCCGGCTCCTGGCGCTACCGCCCGGGCCCCGGCC ATAACCCACCAGGCGGCCCGGCATCGCCGCCTGCTCTTTACCTACCCGGATGGCTCTAAGGTATTCGCCG GCTCGCTGTTTGAGTCGACATGTACCTGGCTCGTTAACGCGTCTAATGTTGACCACCGCCCTGGCGGTGG GCTCTGTCATGCATTTTACCAAAGGTACCCCGCATCCTTTGATGCTGCCTCTTTTGTGATGCGCGACGGC GCGGCCGCCTATACATTAACCCCCCGGCCAATAATTCACGCCGTCGCTCCTGATTATAGGTTGGAACATA ACCCAAAGATGCTTGAGGCTGCCTACCGGGAGACTTGCTCCCGCCTCGGTACCGCTGCATACCCACTCCT CGGGACCGGCATATACCAGGTGCCGATCGGTCCCAGTTTTGACGCCTGGGAGCGGAATCACCGCCCCGGG GATGAGTTGTACCTTCCTGAGCTTGCTGCCAGATGGTTCGAGGCCAATAGGCCGACCTGCCCAACTCTCA CTATAACTGAGGATGTTGCACGGACAGCAAATCTGGCTATCGAACTTGACTCAGCCACAGACGTCGGCCG GGCCTGTGCCGGCTGTCGAGTCACCCCCGGCGTTGTGCAGTACCAGTTTACCGCAGGTGTGCCTGGATCC GGCAAGTCCCGCTCTATTACCCAAGCCGACGTGGACGTTGTCGTGGTCCCGACCCGTGAGTTGCGTAATG CCTGGCGCCGCCGCGGCTTCGCTGCTTTCACCCCGCACACTGCCGCCAGAGTCACCCAGGGGCGCCGGGT TGTCATTGATGAGGCCCCGTCCCTTCCCCCTCACTTGCTGCTGCTCCACATGCAGCGGGCCGCCACCGTC CACCTTCTTGGTGACCCGAATCAGATCCCAGCCATCGACTTTGAGCACGCCGGGCTCGTTCCCGCCATCA GGCCCGATTTGGCCCCCACCTCCTGGTGGCATGTGACCCATCGCTGCCCTGCGGATGTATGTGAGCTGAT CCGTGGCGCATACCCTATGATTCAGACCACTAGTCGGGTCCTCCGGTCGTTGTTCTGGGGTGAGCCTGCT GTTGGGCAGAAACTAGTGTTCACCCAGGCAGCTAAGGCCGCCAACCCCGGTTCAGTGACGGTCCATGAGG CACAGGGCGCTACCTACACAGAGACTACCATTATTGCCACGGCAGATGCTCGAGGCCTCATTCAGTCGTC CCGAGCTCATGCCATTGTTGCCTTGACGCGCCACACTGAGAAGTGCGTCATCATTGACGCACCAGGCCTG CTTCGCGAGGTGGGCATCTCCGATGCAATCGTTAATAACTTTTTCCTTGCTGGTGGCGAAATTGGCCACC AGCGCCCATCTGTTATCCCTCGCGGCAATCCTGACGCCAATGTTGACACCTTGGCTGCCTTCCCGCCGTC TTGCCAGATTAGCGCCTTCCATCAGTTGGCTGAGGAGCTTGGCCACAGACCTGCCCCTGTCGCGGCTGTT CTACCGCCCTGCCCTGAGCTTGAACAGGGCCTTCTCTACCTGCCCCAAGAACTCACCACCTGTGATAGTG TCGTAACATTTGAATTAACAGATATTGTGCACTGTCGTATGGCCGCCCCGAGCCAGCGCAAGGCCGTGCT GTCCACGCTTGTGGGCCATTACGGCCGCCGCACAAAGCTCTACAATGCCTCCCACTCTGATGTTCGCGAC TCTCTCGCCCGTTTTATCCCGGCCATTGGCCACGTACAGGTTACAACCTGTGAATTGTACGAGCTAGTGG AGGCCATGGTCGAGAAGGGCCAGGACGGCTCCGCCGTCCTTGAGCTCGACCTTTGTAACCGCGACGTGTC CAGGATCACCTTCTTCCAGAAAGATTGTAATAAATTCACCACGGGGGAGACCATCGCCCATGGTAAAGTG GGCCAGGGCATTTCGGCCTGGAGTAAGACCTTCTGTGCCCTTTTCGGCCCCTGGTTCCGTGCTATTGAGA AGGCTATCCTGGCCCTGCTCCCTCAGGGTGTGTTTTATGGGGATGCCTTTGATGACACCGTCTTCTCGGC GGCTGTGGCCGCAGCAAGGGCATCCATGGTGTTTGAGAATGACTTTTCTGAGTTTGATTCCACCCAGAAT AATTTTTCCTTGGGCCTAGAGTGTGCTATTATGGTGGAGTGTGGGATGCCGCAGTGGCTCATCCGCTTGT ACCACCTTATAAGGTCTGCGTGGATTCTGCAGGCCCCGAAGGAGTCCCTGCGAGGGTTTTGGAAGAAACA CTCCGGTGAGCCCGGCACCCTTCTATGGAATACAGTCTGGAACATGGCCGTTATCACCCACTGTTATGAT TTCCGCGATCTGCAGGTGGCCGCCTTTAAAGGTGATGATTCGATAGTGCTTTGCAGTGAGTACCGTCAGA GCCCAGGGGCTGCTGTCCTGATTGCTGGCTGTGGCCTAAAGTTGAAGGTGGATTTCCGTCCGATTGGTTT GTATGCAGGTGTTGTGGTGGCCCCCGGCCTTGGCGCGCTTCCTGACGTCGTGCGCTTCGCCGGCCGGCTT ACTGAGAAGAATTGGGGCCCTGGCCCCGAGCGGGCGAAGCAGCTCCGCCTCGCTGTGAGTGATTTTCTCC GCAAGCTCACGAATGTAGCTCAGATGTGTGTGGATGTTGTCTCTCGTGTTTATGGGGTTTCCCCTGGACT CGTTCATAACCTGATTGGCATGCTACAGGCTGTTGCTGACGGCAAGGCTCATTTCACTGAGTCAGTGAAG CCAGTGCTCGACCTGACAAATTCAATCCTGTGTCGGGTGGAATGAATAACATGTCTTCTGCTGCGCCCAT GGGTTCGCGACCATGCGCCCTCGGCCTATTTTGCTGTTGCTCCTCATGTTTCTGCCTATGCTGCCCGCGC CACCGCCCGGTCAGCCGTCTGGCCGCCGCCGTGGGCGGCGCAGCGGCGGTTCCGGCGGTGGTTTCTGGGG TGACCGGGCTGATTCTCAGCCCTTCGCAATCCCCTATATTCATCCAACCAACCCCTTCGCCCCCGATGTC ACCGCTGCGGCCGGGGCTGGACCTCGTGTTCGCCAACCCGCCCGACCACTCGGCTCCGCTTGGCGTGACC AGGCCCAGCGCCCCGCCGCTGCCTCACGTCGTAGACCTACCACAGCTGGGGCCGCGCCGCTAACCGCGGT CGCTCCGGCCCATGACACCCCGCCAGTGCCTGATGTTGACTCCCGCGGCGCCATCCTGCGCCGGCAGTAT AACCTATCAACATCTCCCCTTACCTCTTCCGTGGCCACCGGTACAAACTTGGTTCTTTACGCCGCTCCTC TTAGCCCGCTTCTACCCCTCCAGGACGGCACCAATACTCATATAATGGCTACAGAAGCTTCTAATTATGC CCAGTACCGGGTTGTTCGTGCTACAATTCGCTACCGCCCGCTGGTCCCCAACGCTGTTGGTGGCTACGCC ATCTCCATCTCGTTCTGGCCACAGACCACCACCACCCCGACGTCCGTTGACATGAATTCAATAACCTCGA CTGATGTTCGTATTTTAGTCCAGCCCGGCATAGCCTCCGAGCATGTTATCCCAAGTGAGCGCCTACACTA TCGTAACCAAGGTTGGCGCTCTGTTGAGACCTCCGGGGTGGCGGAGGAGGAGGCCACCTCTGGTCTTGTT ATGCTTTGCATACATGGCTCACTCGTAAACTCTTATACTAATACACCTTATACCGGTGCCCTCGGGCTGT TGGACTTTGCCCTCGAACTTGAGTTCCGCAACCTCACCCCCGGTAATACCAACACGCGGGTCTCCCGTTA CTCCAGCACTGCCCGTCACCGCCTTCGTCGCGGTGCAGATGGGACTGCCGAGCTCACCACCACGGCTGCT ACCCGCTTCATGAAGGACCTCTATTTTACTAGTACTAATGGTGTCGGTGAGATCGGCCGCGGGATAGCGC TTACCCTGTTTAACCTTGCTGACACCCTGCTTGGCGGTCTACCGACAGAATTGATTTCGTCGGCTGGTGG CCAGCTGTTCTACTCTCGCCCCGTCGTCTCAGCCAATGGCGAGCCGACTGTTAAGCTGTATACATCTGTA GAGAATGCTCAGCAGGATAAGGGTATTGCAATCCCGCATGACATCGACCTCGGGGAATCTCGTGTAGTTA TTCAGGATTATGATAACCAACATGAGCAGGACCGACCGACACCTTCCCCAGCCCCATCGCGCCCCTTTTC TGTCCTCCGAGCTAATGATGTGCTTTGGCTTTCTCTCACCGCTGCCGAGTATGACCAGTCCACTTACGGC TCTTCGACCGGCCCAGTCTATGTCTCTGACTCTGTGACCTTGGTTAATGTAGCGACCGGCGCGCAGGCCG TTGCCCGGTCGCTCGACTGGACCAAGGTCACACTTGATGGTCGCCCCCTTTCCACCACCCAGCAGTATTC AAAGACCTTCTTTGTCCTGCCGCTCCGCGGTAAGCTCTCCTTTTGGGAGGCAGGTACTACTAAAGCCGGG TACCCTTATAATTATAACACCACTGCTAGTGACCAACTGCTCGTTGAGAATGCCGCTGGGCATCGGGTTG CTATTTCCACTTACACCACTAGCCTGGGTGCTGGCCCCGTCTCTATTTCCGCGGTTGCTGTTTTAGCCCC CCACTCTGCGCTAGCATTGCTTGAGGATACCATGGACTACCCTGCCCGCGCCCATACTTTCGATGACTTC TGCCCGGAGTGCCGCCCCCTTGGCCTCCAGGGCTGTGCTTTTCAGTCTACTGTCGCTGAGCTTCAGCGCC TTAAGATGAAGGTGGGTAAAACTCGGGAGTTATAGTTTATTTGCTTGTGCCCCCCTTCTTTCTGTTGCTT ATTTCTCATTTCTGCGTTCCGCGCTCCCTGAAAAAA
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