Host Protein General Information

  Protein Name
Tubulin beta chain
  Gene Name
TUBB
  Host Species
Homo sapiens
  Uniprot Entry Name
TBB5_HUMAN
  Protein Families
Tubulin family
  Subcellular Location
Cytoplasm; cytoskeleton
  External Link
NCBI Gene ID
203068
Uniprot ID
P07437
Ensembl ID
ENSG00000196230
HGNC ID
20778
  Related KEGG Pathway
Pathogenic Escherichia coli infection hsa05130            Pathway Map 
Salmonella infection hsa05132            Pathway Map 
Motor proteins hsa04814            Pathway Map 
Gap junction hsa04540            Pathway Map 
Alzheimer disease hsa05010            Pathway Map 
Parkinson disease hsa05012            Pathway Map 
Amyotrophic lateral sclerosis hsa05014            Pathway Map 
Huntington disease hsa05016            Pathway Map 
Prion disease hsa05020            Pathway Map 
Pathways of neurodegeneration - multiple diseases hsa05022            Pathway Map 
Phagosome hsa04145            Pathway Map 
  3D Structure
PDB ID: 3QNZ 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Sindbis virus 5'UTR - 3'UTR RNA Info comparative RIC HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 18 h MIST = 0.14295304 .
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -16.19157054 FZR = 7.05568E-56
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -3.753337482 FZR = 0.145878387
Zika virus (strain MR766) 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5.1 Cells (Human hepatocellular carcinoma cell) . Liver 20 h MIST = 0.978011497 .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/Not Specified Virus Strain) N region RNA Info RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) Calu-3 cell line . Liver . P value < 0.05 .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/IPBCAMS-YL01/2020) 3'UTR RNA Info ChIRP-MS Huh7.5.1 cells . Liver 30 h MIST = 0.840836801 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) A549 Cells (Adenocarcinoma human alveolar basal epithelial cell) . Lung . P-value = 2.86513945941625e-05 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 2.86513945941625e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 1 h, +IFN P-value = 0.000599129643674537 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 3 h, +IFN P-value = 0.000535869071573206 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 0.2 h, +IFN P-value = 0.000494714203812102 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) U2OS Cells (Human osteosarcoma cell) . Bone 0.2 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .
Dengue virus 2 (strain 16681) 5'UTR - 3'UTR RNA Info Thiouracil cross-linking mass spectrometry (TUX-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver 28 h MIST = 2.54 .
Dengue virus 2 (strain 16681) 5'UTR - 3'UTR RNA Info Thiouracil cross-linking mass spectrometry (TUX-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver 28 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
ABT-751 . 3035714  D09EHO  DGIdb
ALBENDAZOLE . 2082  D00KVO  DGIdb
BATABULIN . 216324  D08NAD  DGIdb
BRENTUXIMAB VEDOTIN . ?  D03TIS  DGIdb
CABAZITAXEL . 9854073  D02HSB  DGIdb
COLCHICINE . 6167  D09DHY  DGIdb
colchicine . 6167  D09DHY  DrugCentral
CROLIBULIN . 23649181  D04RSR  DGIdb
CURCUMIN . 969516  D07SDQ  DGIdb
DAVUNETIDE . . D0V1FF  DGIdb
DOCETAXEL . 148124  D0O5WP  DGIdb
DOCETAXEL . 148124  D0O5WP  DGIdb
DOLASTATIN-10 . 9810929  D0PF3J  DGIdb
ERIBULIN . 11354606  D0KK2E  DGIdb
ERIBULIN MESYLATE . 17755248  D0XQ5X  DGIdb
FOSBRETABULIN DISODIUM . 100154  D09OKZ  DGIdb
INDIBULIN . 2929  D04NXL  DGIdb
IXABEPILONE . 6445540  D0W2EK  DGIdb
LARGAZOLE . 24757913  D0Z8PX  DGIdb
LEXIBULIN . . D01JNE  DGIdb
MEBENDAZOLE . 4030  D0J1MI  DGIdb
PACLITAXEL . . . DGIdb
paclitaxel . . . DrugCentral
PLINABULIN . 9949641  D0ZE1O  DGIdb
PODOFILOX . 10607  D0D4HN  DGIdb
SAGOPILONE . 11284169  D0F6YW  DGIdb
SIMOTAXEL . 11286005  D03XCR  DGIdb
VERUBULIN . 11414799  D09BOH  DGIdb
VINBLASTINE . 13342  D0W9MM  DGIdb
VINCRISTINE . 5978  D09QVV  DGIdb
VINDESINE . 40839  D04RLY  DGIdb
VINFLUNINE . 6918295  D0OT9S  DGIdb
VINORELBINE . 5311497  D01HTL  DGIdb
VINORELBINE TARTRATE . 5311497  D01HTL  DGIdb
VORINOSTAT . 5311  D0E7PQ  DGIdb
ZD-6126 . 9896434  D04AMD  DGIdb

Protein Sequence Information

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA
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