Host Protein General Information

  Protein Name
Heat shock protein HSP 90-alpha
  Gene Name
HSP90AA1
  Host Species
Homo sapiens
  Uniprot Entry Name
HS90A_HUMAN
  Protein Families
Heat shock protein 9. family
  EC Number
3.6.4.10
  Subcellular Location
Nucleus
  External Link
NCBI Gene ID
3320
Uniprot ID
P07900
Ensembl ID
ENSG00000080824
HGNC ID
5253
  Related KEGG Pathway
Antigen processing and presentation hsa04612            Pathway Map 
NOD-like receptor signaling pathway hsa04621            Pathway Map 
IL-17 signaling pathway hsa04657            Pathway Map 
Th17 cell differentiation hsa04659            Pathway Map 
Salmonella infection hsa05132            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Chemical carcinogenesis - receptor activation hsa05207            Pathway Map 
Prostate cancer hsa05215            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Fluid shear stress and atherosclerosis hsa05418            Pathway Map 
Necroptosis hsa04217            Pathway Map 
Progesterone-mediated oocyte maturation hsa04914            Pathway Map 
Estrogen signaling pathway hsa04915            Pathway Map 
Protein processing in endoplasmic reticulum hsa04141            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
  3D Structure
PDB ID: 1BYQ 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Sindbis virus 5'UTR - 3'UTR RNA Info Cross-link-assisted mRNP purification (CLAMP) HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 2 h . .
Sindbis virus 5'UTR - 3'UTR RNA Info comparative RIC HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 18 h P = 0.641133204827461 .
Sindbis virus 5'UTR - 3'UTR RNA Info comparative RIC HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 18 h MIST = 0.028043009 .
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -7.41052385 FZR = 9.47285E-11
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -2.563661416 FZR = 1
Sindbis virus (strain Toto1101) 5'UTR - 3'UTR RNA Info Cross-link-assisted mRNP purification (CLAMP) and UV cross-linking and immunoprecipitation sequencing (CLIP-seq) HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 2 h . .
Sindbis virus (strain Toto1101) 5'UTR - 3'UTR RNA Info Cross-link-assisted mRNP purification (CLAMP) and UV cross-linking and immunoprecipitation sequencing (CLIP-seq) HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 2 h . .
Sindbis virus (strain Toto1101) 5'UTR - 3'UTR RNA Info Cross-link-assisted mRNP purification (CLAMP) and UV cross-linking and immunoprecipitation sequencing (CLIP-seq) HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 2 h . .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/Not Specified Virus Strain) N region RNA Info RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) Huh7 cell line . Liver . P value < 0.05 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) A549 Cells (Adenocarcinoma human alveolar basal epithelial cell) . Lung . P-value = 2.00390790910585e-05 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 2.00390790910585e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h . .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h . .
Dengue virus 2 (strain 16681) 5'UTR - 3'UTR RNA Info Thiouracil cross-linking mass spectrometry (TUX-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver 28 h MIST = 1.97 .
Dengue virus 2 (strain 16681) 5'UTR - 3'UTR RNA Info Thiouracil cross-linking mass spectrometry (TUX-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver 28 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
AMLEXANOX . 2161  D0G5UB  DGIdb
BIFONAZOLE . 2378  D0AA2D  DGIdb
BROXYQUINOLINE . . . DGIdb
CELASTROL . 122724  D0I9XH  DGIdb
CHEMBL428064 . 659101  D0Q2KK  DGIdb
CHLOROXINE . 2722  D02HWP  DGIdb
CLIOQUINOL . 2788  D06ABW  DGIdb
CLOTRIMAZOLE . 2812  D09GOS  DGIdb
CYCLOHEXIMIDE . 6197  D06ZWX  DGIdb
DIACEREIN . 26248  D0N1FS  DGIdb
DICHLOROPHEN . . . DGIdb
DIPYRIDAMOLE . 3108  D0F9GE  DGIdb
DISULFIRAM . 3117  D0X5SD  DGIdb
EFUNGUMAB . . D0Y9PZ  DGIdb
famotidine . 5702160  D0K0OZ  DrugCentral
FENTICLOR . . . DGIdb
FLUCONAZOLE . 3365  D09LNI  DGIdb
formoterol . 3410  D04KJO  DrugCentral
GANETESPIB . 135564985  D0I1QI  DGIdb
GELDANAMYCIN . 5288382  D03PKI  DGIdb
HALOFANTRINE HYDROCHLORIDE . 37393  D07MVK  DGIdb
HERBIMYCIN . 5311102  D07DIM  DGIdb
HEXACHLOROPHENE . 3598  D0ZX2G  DGIdb
IODOQUINOL . 3728  D06AEB  DGIdb
ITRACONAZOLE . 55283  D0V4IB  DGIdb
KETOCONAZOLE . 456201  D0B4IF  DGIdb
KW-2478 . 23116322  D08PYO  DGIdb
LUMINESPIB . 135539077  D05BYA  DGIdb
MICONAZOLE . 4189  D00AXJ  DGIdb
midodrine . 4195  D02XJY  DrugCentral
NITROXOLINE . . . DGIdb
NOVOBIOCIN . 54675769  D0Q0PR  DGIdb
OLEOYLETHANOLAMIDE . 5283454  D07MBC  DGIdb
primaquine . 4908  D0T1LK  DrugCentral
PYRITHIONE . . . DGIdb
RADICICOL . 6323491  D0ZA6G  DGIdb
RETASPIMYCIN . 11534420  D0EG5A  DGIdb
RHEIN . 10168  D0M2TY  DGIdb
SILIBININ . 31553  D02ADM  DGIdb
TANESPIMYCIN . 6505803  D0SC2J  DGIdb
TERCONAZOLE . 441383  D01AQT  DGIdb
terfenadine . 5405  D08SOF  DrugCentral
TETRACYCLINE . 54675776  D08NQZ  DGIdb
thiamine . . . DrugCentral
THIRAM . 5455  D02UVS  DGIdb
TRICLABENDAZOLE . 50248  D02VMJ  DGIdb
TRICLOSAN . 5564  D00CSQ  DGIdb
WORTMANNIN . 312145  D0P1JI  DGIdb
XL-888 . 60147023  D0J2RV  DGIdb
ZEARALANONE . 108003  D05GKC  DGIdb
ZERANOL . . . DGIdb

Protein Sequence Information

MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
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