Host Protein General Information

  Protein Name
Heat shock protein HSP 90-beta
  Gene Name
HSP90AB1
  Host Species
Homo sapiens
  Uniprot Entry Name
HS90B_HUMAN
  Protein Families
Heat shock protein 9. family
  Subcellular Location
Cytoplasm
  External Link
NCBI Gene ID
3326
Uniprot ID
P08238
Ensembl ID
ENSG00000096384
HGNC ID
5258
  Related KEGG Pathway
Antigen processing and presentation hsa04612            Pathway Map 
NOD-like receptor signaling pathway hsa04621            Pathway Map 
IL-17 signaling pathway hsa04657            Pathway Map 
Th17 cell differentiation hsa04659            Pathway Map 
Salmonella infection hsa05132            Pathway Map 
Pathways in cancer hsa05200            Pathway Map 
Chemical carcinogenesis - receptor activation hsa05207            Pathway Map 
Prostate cancer hsa05215            Pathway Map 
Lipid and atherosclerosis hsa05417            Pathway Map 
Fluid shear stress and atherosclerosis hsa05418            Pathway Map 
Necroptosis hsa04217            Pathway Map 
Progesterone-mediated oocyte maturation hsa04914            Pathway Map 
Estrogen signaling pathway hsa04915            Pathway Map 
Protein processing in endoplasmic reticulum hsa04141            Pathway Map 
PI3K-Akt signaling pathway hsa04151            Pathway Map 
  3D Structure
PDB ID: 1QZ2 
FASTA   Download
  2D PNG Download  
PDB File Download

Full List of Virus RNA Interacting with This Protien

Virus Name Binding Region RNA Info Detection Method Infection Cell Cell ID Cell Originated Tissue Infection Time Interaction Score 1 Interaction Score 2
Sindbis virus 5'UTR - 3'UTR RNA Info comparative RIC HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 18 h P = 0.884780796344505 .
Sindbis virus 5'UTR - 3'UTR RNA Info comparative RIC HEK293 Cells (Human embryonic kidney cell); Mesc cells (Embryonic stem cell) . Kidney 18 h MIST = 0.007558854 .
Encephalomyocarditis virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = -4.033000786 FZR = 0.024505747
Influenza A virus 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver . Z-score = 3.599328529 FZR = 0.258103298
Zika virus (strain MR766) 5'UTR - 3'UTR RNA Info Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) HuH-7.5.1 Cells (Human hepatocellular carcinoma cell) . Liver 20 h MIST = 0.982434474 .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/Not Specified Virus Strain) N region RNA Info RNA pull-down assays; liquid chromatography with tandem mass spectrometry (LC-MS/MS); Wilcoxon test; MS2 affinity purification coupled with liquid chromatography-mass spectrometry (MAMS) Calu-3 cell line . Liver . P value < 0.05 .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/IPBCAMS-YL01/2020) 3'UTR RNA Info ChIRP-MS Huh7.5.1 cells . Liver 30 h MIST = 0.748119761 .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/France/IDF-220-95/2020) Not Specified Virus Region RNA Info ChIRP-M/S HEK 293T cells stably expressing the human ACE2 receptor (293T-ACE2) . Embryonic kidneys 48 h SAINT score >= 0.79 .
Severe acute respiratory syndrome coronavirus 2 (strain hCoV-19/England/02/2020) Not Specified Virus Region RNA Info UV protein-RNA crosslinking; RNA interactome capture (cRIC); RNA antisense purification coupled with mass spectrometry (RAP-MS) Calu-3 cells (Human lung cancer cells) . Lung 24 h adj.P.Val = 0.092 .
Influenza A virus (strain California/7/2004 (H3N2)) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 5.46694524604146e-05 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 1 h P = 0.000255823905241925 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 0.2 h P = 0.000144710399333444 .
Chikungunya virus (strain 181/25) 5'UTR - 3'UTR RNA Info VIRal Cross-Linking And Solid-phase Purification (VIR-CLASP) BHK-21 Cells (Small hamster kidney fibroblast) . Kidney 3 h P = 0.000105805401278393 .
Dengue virus 2 (strain 16681) 5'UTR - 3'UTR RNA Info Thiouracil cross-linking mass spectrometry (TUX-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver 28 h MIST = 2.1 .
Dengue virus 2 (strain 16681) 5'UTR - 3'UTR RNA Info Thiouracil cross-linking mass spectrometry (TUX-MS) HuH-7.5 Cells (Human hepatocellular carcinoma cell) . Liver 28 h . .

Potential Drug(s) that Targets This Protein

Drug Name DrunkBank ID Pubchem ID TTD ID REF
BEVACIZUMAB . . D04KBL  DGIdb
CELASTROL . 122724  D0I9XH  DGIdb
DIACEREIN . 26248  D0N1FS  DGIdb
DIPYRIDAMOLE . 3108  D0F9GE  DGIdb
GANETESPIB . 135564985  D0I1QI  DGIdb
GELDANAMYCIN . 5288382  D03PKI  DGIdb
LUMINESPIB . 135539077  D05BYA  DGIdb
NOVOBIOCIN . 54675769  D0Q0PR  DGIdb
PU-H71 . 9549213  D01FYA  DGIdb
RADICICOL . 6323491  D0ZA6G  DGIdb
RETASPIMYCIN . 11534420  D0EG5A  DGIdb
RHEIN . 10168  D0M2TY  DGIdb
SILIBININ . 31553  D02ADM  DGIdb
TANESPIMYCIN . 6505803  D0SC2J  DGIdb
TAS-116 . 67501411  D0F3NF  DGIdb
TETRACYCLINE . 54675776  D08NQZ  DGIdb
XL-888 . 60147023  D0J2RV  DGIdb
ZEARALANONE . 108003  D05GKC  DGIdb
ZERANOL . . . DGIdb

Protein Sequence Information

MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
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